PMID- 26029939
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150602
LR  - 20220419
IS  - 1523-7834 (Print)
IS  - 1523-7834 (Linking)
VI  - 41
IP  - 1
DP  - 2015
TI  - A Cryptic t(11;14) Translocation in Mantle Cell Lymphoma Highlights the 
      Importance of FISH.
PG  - 13-6
AB  - Mantle cell lymphoma (MCL) is a mature B-cell neoplasm composed of monomorphic 
      small to medium-sized atypical lymphocytes arising from naive mantle zone 
      B-cells, with a generally aggressive and incurable clinical course. The 
      t(11;14)(q13;q32) between IGH@ and CCND1 is present in almost all cases of MCL. 
      Secondary cytogenetic abnormalities are common, and have been associated in some 
      cases with clinical progression. Variant and cryptic t(11;14) translocations have 
      been reported as well. Herein, we present the case of an 80-year old woman with 
      classical MCL, and a cryptic t(11;14) translocation detected by fluorescence in 
      situ hybridization (FISH), and not by conventional cytogenetics. FISH on 
      previously G-banded metaphases showed a cryptic CCND1-IGH@ fusion signal on a 
      derivative chromosome 10, and another fusion signal on one of the abnormal copies 
      of chromosome 11. Cases such as this highlight the importance of FISH studies as 
      part of an algorithmic and multidisciplinary approach to diagnosis.
FAU - Kallen, Michael E
AU  - Kallen ME
AD  - Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, 
      University of California Los Angeles, Los Angeles, CA.
FAU - Kim, Yeun
AU  - Kim Y
AD  - Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, 
      University of California Los Angeles, Los Angeles, CA.
FAU - Yang, Lynn
AU  - Yang L
AD  - Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, 
      University of California Los Angeles, Los Angeles, CA.
FAU - Rao, Nagesh P
AU  - Rao NP
AD  - Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, 
      University of California Los Angeles, Los Angeles, CA.
FAU - Tirado, Carlos A
AU  - Tirado CA
AD  - Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, 
      University of California Los Angeles, Los Angeles, CA.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Assoc Genet Technol
JT  - Journal of the Association of Genetic Technologists
JID - 9807282
EDAT- 2015/06/02 06:00
MHDA- 2015/06/02 06:01
CRDT- 2015/06/02 06:00
PHST- 2015/06/02 06:00 [entrez]
PHST- 2015/06/02 06:00 [pubmed]
PHST- 2015/06/02 06:01 [medline]
PST - ppublish
SO  - J Assoc Genet Technol. 2015;41(1):13-6.