PMID- 26030023
OWN - NLM
STAT- MEDLINE
DCOM- 20150916
LR  - 20210102
IS  - 1529-2916 (Electronic)
IS  - 1529-2908 (Print)
IS  - 1529-2908 (Linking)
VI  - 16
IP  - 7
DP  - 2015 Jul
TI  - The transcription factor TFEB acts as a molecular switch that regulates exogenous 
      antigen-presentation pathways.
PG  - 729-36
LID - 10.1038/ni.3196 [doi]
AB  - Dendritic cells (DCs) can initiate immune responses by presenting exogenous 
      antigens to T cells via both major histocompatibility complex (MHC) class I 
      pathways and MHC class II pathways. Lysosomal activity has an important role in 
      modulating the balance between these two pathways. The transcription factor TFEB 
      regulates lysosomal function by inducing lysosomal activation. Here we report 
      that TFEB expression inhibited the presentation of exogenous antigen by MHC class 
      I while enhancing presentation via MHC class II. TFEB promoted phagosomal 
      acidification and protein degradation. Furthermore, we found that the activation 
      of TFEB was regulated during DC maturation and that phagosomal acidification was 
      impaired in DCs in which the gene encoding TFEB was silenced. Our data indicate 
      that TFEB is a key participant in the differential regulation of the presentation 
      of exogenous antigens by DCs.
FAU - Samie, Mohammad
AU  - Samie M
AD  - Department of Immunobiology, Howard Hughes Medical Institute, Yale University 
      School of Medicine, New Haven, Connecticut, USA.
FAU - Cresswell, Peter
AU  - Cresswell P
AD  - Department of Immunobiology, Howard Hughes Medical Institute, Yale University 
      School of Medicine, New Haven, Connecticut, USA.
LA  - eng
GR  - R01 AI097206/AI/NIAID NIH HHS/United States
GR  - R01-AI097206/AI/NIAID NIH HHS/United States
GR  - Howard Hughes Medical Institute/United States
GR  - P30 CA016359/CA/NCI NIH HHS/United States
GR  - T32 HL007974/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20150601
PL  - United States
TA  - Nat Immunol
JT  - Nature immunology
JID - 100941354
RN  - 0 (Antigens)
RN  - 0 (Basic Helix-Loop-Helix Leucine Zipper Transcription Factors)
RN  - 0 (Histocompatibility Antigens Class II)
RN  - 0 (Tcfeb protein, mouse)
SB  - IM
MH  - Animals
MH  - Antigen Presentation/*immunology
MH  - Antigens/*immunology
MH  - Basic Helix-Loop-Helix Leucine Zipper Transcription 
      Factors/genetics/*immunology/metabolism
MH  - Cells, Cultured
MH  - Chlorocebus aethiops
MH  - Cross-Priming/immunology
MH  - Flow Cytometry
MH  - HEK293 Cells
MH  - Histocompatibility Antigens Class II/immunology
MH  - Humans
MH  - Hydrogen-Ion Concentration
MH  - Mice, Inbred C57BL
MH  - Microscopy, Confocal
MH  - Phagosomes/immunology/metabolism
MH  - Proteolysis
MH  - RNA Interference/immunology
MH  - Signal Transduction/*immunology
MH  - Spleen/cytology/immunology/metabolism
MH  - Vero Cells
PMC - PMC5609676
MID - NIHMS897594
EDAT- 2015/06/02 06:00
MHDA- 2015/09/17 06:00
PMCR- 2017/09/22
CRDT- 2015/06/02 06:00
PHST- 2015/02/24 00:00 [received]
PHST- 2015/05/05 00:00 [accepted]
PHST- 2015/06/02 06:00 [entrez]
PHST- 2015/06/02 06:00 [pubmed]
PHST- 2015/09/17 06:00 [medline]
PHST- 2017/09/22 00:00 [pmc-release]
AID - ni.3196 [pii]
AID - 10.1038/ni.3196 [doi]
PST - ppublish
SO  - Nat Immunol. 2015 Jul;16(7):729-36. doi: 10.1038/ni.3196. Epub 2015 Jun 1.