PMID- 26030295
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20151026
LR  - 20201001
IS  - 1523-7834 (Print)
IS  - 1523-7834 (Linking)
VI  - 40
IP  - 4
DP  - 2014
TI  - Cytogenetics of melanoma: a review.
PG  - 209-18
AB  - Malignant melanoma is an aggressive cutaneous neoplasm whose incidence has 
      continued to increase worldwide. Currently, histopathologic examination of 
      specimens is the gold standard for the diagnosis and categorization of melanoma. 
      Cytogenetic analysis represents a powerful, and currently underused, adjunct to 
      traditional histologic examination in distinguishing nevi and melanomas. 
      Chromosomal studies have shown that malignant melanomas often contain multiple 
      chromosomal alterations, most commonly of chromosomes 1, 6, 7, 9, 10 and 11. 
      These chromosomes often include genes within the MAPK molecular pathway, which is 
      involved in the development and progression of melanoma. Fluorescence in situ 
      hybridization (FISH) can detect a number of recurrent anomalies, and commercially 
      available kits for melanoma detection have been devised. The utility of 
      cytogenetics in melanocytic lesions at certain anatomic sites has been evaluated, 
      including acral lesions, uveal lesions, and lymph node metastases. Recurring 
      cytogenetic anomalies have been defined in various challenging histologic 
      subtypes, such as desmoplastic melanomas and Spitzoid lesions. Cytogenetic 
      analysis may also be used to provide supplementary information in 
      prognostication, particularly in uveal melanomas. We provide a brief review of 
      the molecular pathways found in melanoma and a summary of what is known and 
      remains unknown regarding cytogenetic aberrations associated with malignant 
      melanoma.
FAU - James, Aaron W Md
AU  - James AW Md
AD  - Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, 
      University of California, Los Angeles, Los Angeles, CA.
FAU - Chang, Le Bs
AU  - Chang L Bs
AD  - Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, 
      University of California, Los Angeles, Los Angeles, CA.
FAU - Shrestha, Swati
AU  - Shrestha S
AD  - Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, 
      University of California, Los Angeles, Los Angeles, CA.
FAU - Cochran, Alistair Md
AU  - Cochran A Md
AD  - Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, 
      University of California, Los Angeles, Los Angeles, CA.
FAU - Binder, Scott Md
AU  - Binder S Md
AD  - Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, 
      University of California, Los Angeles, Los Angeles, CA.
FAU - Tirado, Carlos A PhD
AU  - Tirado CA PhD
AD  - Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, 
      University of California, Los Angeles, Los Angeles, CA.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Assoc Genet Technol
JT  - Journal of the Association of Genetic Technologists
JID - 9807282
EDAT- 2014/01/01 00:00
MHDA- 2014/01/01 00:01
CRDT- 2015/06/02 06:00
PHST- 2015/06/02 06:00 [entrez]
PHST- 2014/01/01 00:00 [pubmed]
PHST- 2014/01/01 00:01 [medline]
PST - ppublish
SO  - J Assoc Genet Technol. 2014;40(4):209-18.