PMID- 26031149
OWN - NLM
STAT- MEDLINE
DCOM- 20150619
LR  - 20181202
IS  - 0023-2149 (Print)
IS  - 0023-2149 (Linking)
VI  - 93
IP  - 1
DP  - 2015
TI  - [Detection of cytochrome P4502C19 gene polymorphism to optimize therapy of 
      acid-dependent diseases].
PG  - 46-50
AB  - Therapeutic efficacy of proton pump inhibitors (PPI) used in therapy of 
      acid-dependent diseases largely depends on cytochrome CYP2C9 activity. The rate 
      of washout of medications metabolized by this enzyme varies 5-20-fold in 
      different patients and ethnic groups, in the first place due to genetic 
      polymorphism. The natural metabolic status of CYP2C19 can be evaluated by 
      genotyping and non-invasive 13C-pantoprazole breath test. The aim of the study 
      was to assess the frequency of fast, intermediate, and slow types of metabolism 
      in Crimeans suffering gastroesophageal reflux disease by the latter method. 
      MATERIAL AND METHODS: The study included 32 patients (21 women, 11 men) aged 
      18-60 (mean 42.25+/-3.02) years. They underwent the 13C-pantoprazole breath test 
      prior to the onset of therapy. RESULTS: The patients were divided into 3 groups 
      based on the results of the test. 12 (37.5%) of them had fast-type metabolism 
      (mean delta over base (DOB) 4.725%+-0.3), 14 (43.75%) had intermediate metabolism 
      (mean DOB 2.44+/-0.162%) and 6 (18,75%) had slow metabolism (mean DOB 0.85+/-0.22%). 
      The study showed the prevalence of fast and intermediate type metabolism in the 
      inhabitants of Crimea which suggests the necessity of correction of standard PPI 
      doses.
FAU - Klyaritskaya, I L
AU  - Klyaritskaya IL
FAU - Rabotyagova, Yu S
AU  - Rabotyagova YS
LA  - rus
PT  - Journal Article
PL  - Russia (Federation)
TA  - Klin Med (Mosk)
JT  - Klinicheskaia meditsina
JID - 2985204R
RN  - 0 (2-Pyridinylmethylsulfinylbenzimidazoles)
RN  - 0 (Proton Pump Inhibitors)
RN  - 9035-51-2 (Cytochrome P-450 Enzyme System)
RN  - D8TST4O562 (Pantoprazole)
SB  - IM
MH  - 2-Pyridinylmethylsulfinylbenzimidazoles/*metabolism
MH  - Adolescent
MH  - Adult
MH  - Cytochrome P-450 Enzyme System/*genetics
MH  - Female
MH  - Gastroesophageal Reflux/*drug therapy
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Pantoprazole
MH  - Proton Pump Inhibitors/*metabolism
MH  - Young Adult
EDAT- 2015/06/03 06:00
MHDA- 2015/06/20 06:00
CRDT- 2015/06/03 06:00
PHST- 2015/06/03 06:00 [entrez]
PHST- 2015/06/03 06:00 [pubmed]
PHST- 2015/06/20 06:00 [medline]
PST - ppublish
SO  - Klin Med (Mosk). 2015;93(1):46-50.