PMID- 26031512
OWN - NLM
STAT- MEDLINE
DCOM- 20161108
LR  - 20181113
IS  - 1435-1544 (Electronic)
IS  - 0938-7412 (Linking)
VI  - 26
IP  - 2
DP  - 2015 Jun
TI  - Ventricular tachycardias in patients with pulmonary hypertension: an 
      underestimated prevalence? A prospective clinical study.
PG  - 155-62
LID - 10.1007/s00399-015-0364-8 [doi]
AB  - BACKGROUND: Sudden cardiac death (SCD) accounts for approximately 30 % in 
      patients with pulmonary arterial hypertension (PAH). The exact circumference for 
      SCD in this patient population is still unclear. Malignant cardiac arrhythmias 
      are reported to be rarely present. There are no systematic data concerning 
      long-term electrocardiographic (ECG) recording in patients with PAH. OBJECTIVES: 
      We sought to investigate the rate of potentially relevant arrhythmias in patients 
      with pulmonary hypertension (PH). METHODS: Consecutive patients without diagnosis 
      of known cardiac arrhythmias followed in our outpatient clinic for PH were 
      enrolled in the study. All patients underwent a 72-h Holter ECG. Clinical data, 
      6-min walk distance, laboratory values, and echocardiography were 
      collected/performed. RESULTS: Ninety-two consecutive patients (New York Heart 
      Association class (NYHA) III/IV: 65.2 %/5.4 %, PH Group 1: 35.9 %, Group 3: 
      10.9 %, Group 4: 28.3 %, Group 5: 2.2 %) were investigated. Relevant arrhythmias 
      were newly detected in 17 patients: non-sustained ventricular tachycardia 
      (n = 12), intermittent second-degree heart block (n = 1), intermittent 
      third-degree heart block (n= 3), and atrial flutter (n = 1). Echocardiographic 
      systolic pulmonary pressure and diameter of the right heart were elevated in 
      patients with relevant arrhythmias. Right heart catheterization revealed higher 
      pulmonary vascular resistance (672 vs. 542 dyn . s . cm(-5), p = 0.247) and lower 
      cardiac index (2.46 vs. 2.82 l/min/m(2), p = 0.184). CONCLUSIONS: Ventricular 
      tachycardias occur more often in PH patients than previously reported. However, 
      the prognostic relevance of non-sustained ventricular tachycardias in this cohort 
      remains unclear. As a large number of PH patients die from SCD, closer 
      monitoring, e.g., using implantable event recorders, might be useful to identify 
      patients at high risk.
FAU - Bandorski, Dirk
AU  - Bandorski D
AD  - University of Giessen and Marburg Lung Center (UGMLC), Giessen, Germany, 
      dirk.bandorski@khw.med.uni-giessen.de.
FAU - Erkapic, D
AU  - Erkapic D
FAU - Stempfl, J
AU  - Stempfl J
FAU - Holtgen, R
AU  - Holtgen R
FAU - Grunig, E
AU  - Grunig E
FAU - Schmitt, J
AU  - Schmitt J
FAU - Chasan, R
AU  - Chasan R
FAU - Grimminger, J
AU  - Grimminger J
FAU - Neumann, T
AU  - Neumann T
FAU - Hamm, C W
AU  - Hamm CW
FAU - Seeger, W
AU  - Seeger W
FAU - Ghofrani, H A
AU  - Ghofrani HA
FAU - Gall, H
AU  - Gall H
LA  - eng
PT  - Journal Article
DEP - 20150602
PL  - Germany
TA  - Herzschrittmacherther Elektrophysiol
JT  - Herzschrittmachertherapie & Elektrophysiologie
JID - 9425873
SB  - IM
MH  - Adult
MH  - Age Distribution
MH  - Aged
MH  - Aged, 80 and over
MH  - Asymptomatic Diseases
MH  - Causality
MH  - Comorbidity
MH  - Electrocardiography, Ambulatory/*statistics & numerical data
MH  - False Negative Reactions
MH  - Female
MH  - Germany/epidemiology
MH  - Humans
MH  - Hypertension, Pulmonary/*diagnosis/*epidemiology
MH  - Male
MH  - Middle Aged
MH  - Prevalence
MH  - Prospective Studies
MH  - Reproducibility of Results
MH  - Risk Assessment
MH  - Sensitivity and Specificity
MH  - Sex Distribution
MH  - Tachycardia, Ventricular/*diagnosis/*epidemiology
MH  - Young Adult
EDAT- 2015/06/03 06:00
MHDA- 2016/11/09 06:00
CRDT- 2015/06/03 06:00
PHST- 2015/03/09 00:00 [received]
PHST- 2015/03/10 00:00 [accepted]
PHST- 2015/06/03 06:00 [entrez]
PHST- 2015/06/03 06:00 [pubmed]
PHST- 2016/11/09 06:00 [medline]
AID - 10.1007/s00399-015-0364-8 [doi]
PST - ppublish
SO  - Herzschrittmacherther Elektrophysiol. 2015 Jun;26(2):155-62. doi: 
      10.1007/s00399-015-0364-8. Epub 2015 Jun 2.