PMID- 26031712
OWN - NLM
STAT- MEDLINE
DCOM- 20180509
LR  - 20181202
IS  - 1600-0765 (Electronic)
IS  - 0022-3484 (Linking)
VI  - 51
IP  - 1
DP  - 2016 Feb
TI  - Ridge augmentation using recombinant human fibroblast growth factor-2 with 
      biodegradable gelatin sponges incorporating beta-tricalcium phosphate: a preclinical 
      study in dogs.
PG  - 77-85
LID - 10.1111/jre.12285 [doi]
AB  - BACKGROUND AND OBJECTIVE: Fibroblast growth factor-2 (FGF-2) regulates the 
      proliferation and differentiation of osteogenic cells, resulting in the promotion 
      of bone formation. Biodegradable gelatin sponges incorporating beta-tricalcium 
      phosphate (beta-TCP) have been reported as a scaffold, which has the ability to 
      control growth factor release, offering sufficient mechanical strength and 
      efficient migration of mesenchymal cells. In this study, we evaluated the effects 
      of the combined use of recombinant human FGF-2 (rhFGF-2) and gelatin/beta-TCP sponge 
      on ridge augmentation in dogs. MATERIAL AND METHODS: Six male beagle dogs were 
      used in this study. Twelve wk after tooth extraction, bilateral 10 x 5 mm (width 
      x depth) saddle-type defects were created 3 mm apart from the mesial side of the 
      maxillary canine. At the experimental sites, the defects were filled with 
      gelatin/beta-TCP sponge infiltrated with 0.3% rhFGF-2, whereas gelatin/beta-TCP sponge 
      infiltrated with saline was applied to the control sites. Eight wk after surgery, 
      qualitative and quantitative analyses were performed. RESULTS: There were no 
      signs of clinical inflammation at 8 wk after surgery. Histometric measurements 
      revealed that new bone height at the experimental sites (2.98 +/- 0.65 mm) was 
      significantly greater than that at the control sites (1.56 +/- 0.66 mm; p = 0.004). 
      The total tissue height was greater at the experimental sites (6.62 +/- 0.66 mm) 
      than that at the control sites (5.95 +/- 0.74 mm), although there was no 
      statistical significant difference (p = 0.051). Cast model measurements revealed 
      that the residual defect height at the experimental sites (2.31 +/- 0.50 mm) was 
      significantly smaller than that at the control sites (3.51 +/- 0.78 mm; p = 0.012). 
      CONCLUSION: The combined use of rhFGF-2 and gelatin/beta-TCP sponge promotes ridge 
      augmentation in canine saddle-type bone defects.
CI  - (c) 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Hoshi, S
AU  - Hoshi S
AD  - Department of Periodontology, Graduate School of Medical and Dental Science, 
      Tokyo Medical and Dental University, Tokyo, Japan.
FAU - Akizuki, T
AU  - Akizuki T
AD  - Department of Periodontology, Graduate School of Medical and Dental Science, 
      Tokyo Medical and Dental University, Tokyo, Japan.
AD  - Division of Periodontology, Department of Oral Science, Graduate School of 
      Dentistry, Kanagawa Dental University, Kanagawa, Japan.
FAU - Matsuura, T
AU  - Matsuura T
AD  - Department of Periodontology, Graduate School of Medical and Dental Science, 
      Tokyo Medical and Dental University, Tokyo, Japan.
FAU - Ikawa, T
AU  - Ikawa T
AD  - Department of Periodontology, Graduate School of Medical and Dental Science, 
      Tokyo Medical and Dental University, Tokyo, Japan.
FAU - Kinoshita, A
AU  - Kinoshita A
AD  - Department of Educational Media Development, Institute for Library and Media 
      Information Technology, Tokyo Medical and Dental University, Tokyo, Japan.
FAU - Oda, S
AU  - Oda S
AD  - Oral Diagnosis and General Dentistry, University Hospital of Dentistry, Tokyo 
      Medical and Dental University, Tokyo, Japan.
FAU - Tabata, Y
AU  - Tabata Y
AD  - Department of Biomaterials, Kyoto University, Kyoto, Japan.
FAU - Matsui, M
AU  - Matsui M
AD  - Department of Biomaterials, Kyoto University, Kyoto, Japan.
FAU - Izumi, Y
AU  - Izumi Y
AD  - Department of Periodontology, Graduate School of Medical and Dental Science, 
      Tokyo Medical and Dental University, Tokyo, Japan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150529
PL  - United States
TA  - J Periodontal Res
JT  - Journal of periodontal research
JID - 0055107
RN  - 0 (Calcium Phosphates)
RN  - 103107-01-3 (Fibroblast Growth Factor 2)
RN  - 9000-70-8 (Gelatin)
SB  - IM
MH  - Animals
MH  - Bone Regeneration
MH  - Calcium Phosphates
MH  - Dogs
MH  - Fibroblast Growth Factor 2/*therapeutic use
MH  - Gelatin
MH  - Humans
MH  - Male
MH  - Osteogenesis
OTO - NOTNLM
OT  - alveolar ridge augmentation
OT  - beta-tricalcium phosphate
OT  - fibroblast growth factor-2
OT  - gelatin
EDAT- 2015/06/03 06:00
MHDA- 2018/05/10 06:00
CRDT- 2015/06/03 06:00
PHST- 2015/03/23 00:00 [accepted]
PHST- 2015/06/03 06:00 [entrez]
PHST- 2015/06/03 06:00 [pubmed]
PHST- 2018/05/10 06:00 [medline]
AID - 10.1111/jre.12285 [doi]
PST - ppublish
SO  - J Periodontal Res. 2016 Feb;51(1):77-85. doi: 10.1111/jre.12285. Epub 2015 May 
      29.