PMID- 26033703
OWN - NLM
STAT- MEDLINE
DCOM- 20170428
LR  - 20170428
IS  - 1203-4754 (Print)
IS  - 1203-4754 (Linking)
VI  - 20
IP  - 1
DP  - 2016 Jan
TI  - Assessment of Tissue Level of Histone Deactylase-2 (HDAC-2) in Patients With 
      Mycosis Fungoides.
PG  - 40-3
LID - 10.1177/1203475415589055 [doi]
AB  - BACKGROUND: Histone deactylases (HDAC) have a role in the pathogenesis of mycosis 
      fungoides (MF) through their actions on different apoptosis pathways. OBJECTIVE: 
      To assess the possible role played by HDAC-2 in MF by estimating the tissue 
      expression of HDAC2 mRNA in different stages of MF. METHODS: This study included 
      28 MF patients and 30 controls. The HDAC-2 levels were detected by real-time 
      polymerase chain reaction (PCR). Correlations of HDAC-2 levels with clinical 
      presentation and different stages of MF were analyzed. RESULTS: Mean HDAC-2 level 
      was significantly higher in patients (P < .001) than in controls. HDAC-2 highest 
      mean value was significantly detected in patients with stage IIb, and the lowest 
      mean value was detected in patients with stage Ia (P < .001). CONCLUSION: 
      Up-regulation of tissue HDAC-2 in MF patients might develop a new approach in the 
      understanding of the pathogenesis of MF. Histone deactylases are important 
      targets for molecular cancer therapeutics.
CI  - (c) The Author(s) 2015.
FAU - El Tawdy, Amira
AU  - El Tawdy A
AD  - Faculty of Medicine, Cairo University, Cairo, Egypt.
FAU - Amin, Iman
AU  - Amin I
AD  - Faculty of Medicine, Cairo University, Cairo, Egypt.
FAU - Abdel Hay, Rania
AU  - Abdel Hay R
AD  - Faculty of Medicine, Cairo University, Cairo, Egypt 
      raniamounir@kasralainy.edu.eg.
FAU - Rashed, Laila
AU  - Rashed L
AD  - Faculty of Medicine, Cairo University, Cairo, Egypt.
FAU - Gad, Zeiad
AU  - Gad Z
AD  - National Cancer Institute, Cairo University, Cairo, Egypt.
LA  - eng
PT  - Journal Article
DEP - 20150601
PL  - United States
TA  - J Cutan Med Surg
JT  - Journal of cutaneous medicine and surgery
JID - 9614685
RN  - 0 (RNA, Messenger)
RN  - EC 3.5.1.98 (HDAC2 protein, human)
RN  - EC 3.5.1.98 (Histone Deacetylase 2)
SB  - IM
MH  - Adult
MH  - Apoptosis
MH  - Case-Control Studies
MH  - Female
MH  - Gene Expression
MH  - Histone Deacetylase 2/*analysis/biosynthesis/*genetics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Mycosis Fungoides/chemistry/*genetics/metabolism/pathology
MH  - Neoplasm Staging
MH  - RNA, Messenger
MH  - Skin/*chemistry/metabolism
MH  - Skin Neoplasms/chemistry/*genetics/metabolism/pathology
MH  - Up-Regulation
OTO - NOTNLM
OT  - HDAC-2
OT  - apoptosis
OT  - cancer therapeutics
OT  - cell cycle
OT  - mycosis fungoides
EDAT- 2015/06/03 06:00
MHDA- 2017/04/30 06:00
CRDT- 2015/06/03 06:00
PHST- 2015/06/03 06:00 [entrez]
PHST- 2015/06/03 06:00 [pubmed]
PHST- 2017/04/30 06:00 [medline]
AID - 1203475415589055 [pii]
AID - 10.1177/1203475415589055 [doi]
PST - ppublish
SO  - J Cutan Med Surg. 2016 Jan;20(1):40-3. doi: 10.1177/1203475415589055. Epub 2015 
      Jun 1.