PMID- 26034606
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150602
LR  - 20181113
IS  - 2052-4439 (Print)
IS  - 2052-4439 (Electronic)
IS  - 2052-4439 (Linking)
VI  - 1
IP  - 1
DP  - 2014
TI  - High body mass index and allergies in schoolchildren: the French six cities 
      study.
PG  - e000054
LID - 10.1136/bmjresp-2014-000054 [doi]
LID - e000054
AB  - BACKGROUND: The prevalence of allergic diseases such as asthma, allergic rhinitis 
      and atopic dermatitis is increasing rapidly worldwide, especially among children 
      and in western countries. This coincides with an increase in body mass index 
      (BMI), which might be a major risk factor for atopic diseases. OBJECTIVES: To 
      study the relationship between high BMI and allergic diseases, as well as 
      skin-prick test (SPT) positivity and exercise-induced asthma (EIA) in 6733 
      randomly selected schoolchildren aged 9-11 years in the French Six Cities Study. 
      METHODS: A cross-sectional study was carried out in Bordeaux, Clermont-Ferrand, 
      Creteil, Marseille, Reims and Strasbourg. Parental questionnaires based on the 
      International Study on Asthma and Allergies in Childhood (ISAAC) were used to 
      collect information on allergic diseases and potential risk factors. Skin-prick 
      testing to common allergens was performed to identify the existence of an 
      allergic hypersensitivity and an exercise test was also performed to assess EIA. 
      Height and weight were collected by trained investigators. After computing the 
      BMI (weight/height squared), the International Obesity Task Force (IOTF) cut-offs 
      were used to define overweight and obesity. The children were also classified as 
      wheezing or non-wheezing. RESULTS: After adjustment for confounding factors, 
      lifetime asthma was associated with high BMI among non-wheezing children 
      (adjusted OR, aOR=1.98, 95% CI (1.06 to 3.70)). In addition, lifetime and 
      past-year allergic rhinitis was associated with high BMI in wheezing children 
      (aOR=1.63, (1.09 to 2.45) and aOR=2.20, (1.13 to 4.27)). However, high BMI was 
      not significantly associated with eczema, SPT positivity or EIA. CONCLUSIONS: 
      This study shows a positive association between high BMI and lifetime asthma in 
      non-wheezing children. High BMI was also associated with lifetime and past-year 
      allergic rhinitis. Further studies are needed to provide causal evidence.
FAU - Saadeh, Danielle
AU  - Saadeh D
AD  - Clinical and Epidemiological Research Laboratory, Faculty of Pharmacy , Lebanese 
      University , Hadath , Lebanon ; INSERM U897, Institut de Sante Publique 
      d'Epidemiologie et de Developpement, Universite de Bordeaux , Bordeaux , France.
FAU - Salameh, Pascale
AU  - Salameh P
AD  - Clinical and Epidemiological Research Laboratory, Faculty of Pharmacy , Lebanese 
      University , Hadath , Lebanon.
FAU - Caillaud, Denis
AU  - Caillaud D
AD  - Hopital Gabriel Montpied , Clermont-Ferrand , France.
FAU - Charpin, Denis
AU  - Charpin D
AD  - Hopital Nord , Marseille , France.
FAU - de Blay, Frederic
AU  - de Blay F
AD  - Hopital Civil , Strasbourg , France.
FAU - Kopferschmitt, Christine
AU  - Kopferschmitt C
AD  - Hopital Civil , Strasbourg , France.
FAU - Lavaud, Francois
AU  - Lavaud F
AD  - Hopital Maison Blanche , Reims , France.
FAU - Annesi-Maesano, Isabella
AU  - Annesi-Maesano I
AD  - EPAR, UMR-S 1136, Institute Pierre Louis of Epidemiology and Public Health, 
      INSERM and UPMC Sorbonne Universites , Paris , France.
FAU - Baldi, Isabelle
AU  - Baldi I
AD  - INSERM U897, Institut de Sante Publique d'Epidemiologie et de Developpement, 
      Universite de Bordeaux , Bordeaux , France.
FAU - Raherison, Chantal
AU  - Raherison C
AD  - INSERM U897, Institut de Sante Publique d'Epidemiologie et de Developpement, 
      Universite de Bordeaux , Bordeaux , France ; Service des maladies respiratoires , 
      Hopital du Haut-Leveque, Avenue de Magellan , Pessac , France.
LA  - eng
PT  - Journal Article
DEP - 20141224
PL  - England
TA  - BMJ Open Respir Res
JT  - BMJ open respiratory research
JID - 101638061
PMC - PMC4448005
OTO - NOTNLM
OT  - Allergic Alveolitis
OT  - Asthma
OT  - Asthma Epidemiology
OT  - Immunodeficiency
EDAT- 2014/01/01 00:00
MHDA- 2014/01/01 00:01
PMCR- 2014/12/24
CRDT- 2015/06/03 06:00
PHST- 2014/07/23 00:00 [received]
PHST- 2014/10/03 00:00 [accepted]
PHST- 2015/06/03 06:00 [entrez]
PHST- 2014/01/01 00:00 [pubmed]
PHST- 2014/01/01 00:01 [medline]
PHST- 2014/12/24 00:00 [pmc-release]
AID - bmjresp-2014-000054 [pii]
AID - 10.1136/bmjresp-2014-000054 [doi]
PST - epublish
SO  - BMJ Open Respir Res. 2014 Dec 24;1(1):e000054. doi: 10.1136/bmjresp-2014-000054. 
      eCollection 2014.