PMID- 26035806
OWN - NLM
STAT- MEDLINE
DCOM- 20160824
LR  - 20220408
IS  - 1536-5166 (Electronic)
IS  - 1070-8022 (Linking)
VI  - 35
IP  - 4
DP  - 2015 Dec
TI  - Corresponding Ganglion Cell Atrophy in Patients With Postgeniculate Homonymous 
      Visual Field Loss.
PG  - 353-9
LID - 10.1097/WNO.0000000000000268 [doi]
AB  - BACKGROUND: The goal of our study was to look for the presence of homonymous 
      ganglion cell layer-inner plexiform layer complex (GCL-IPL) thinning using 
      spectral-domain optical coherence tomography (SD-OCT) in patients with a history 
      of adult-onset injury to the postgeniculate pathways with rigorous radiological 
      exclusion of geniculate and pregeniculate pathology. METHODS: We performed a 
      retrospective review of twenty-two patients (ages 24-75 y, 6 men, 16 women) with 
      homonymous visual field (VF) defects secondary to postgeniculate injury examining 
      the GCL-IPL with SD-OCT. An additional fifteen patients (ages 28-85 y, 5 men, 10 
      women) with no visual pathway pathology served as controls. Using segmentation 
      analysis software applied to the macular scan, a normalized asymmetry score was 
      calculated for each eye comparing GCL-IPL thickness ipsilateral vs contralateral 
      to the patient's brain lesions. RESULTS: We found that 15 of the twenty-two 
      subjects had a relative thinning of the GCL-IPL ipsilateral to the postgeniculate 
      lesion in both eyes (represented by a positive normalized asymmetry score in both 
      eyes), whereas a similar pattern of right/left asymmetry was found in 4 controls 
      (P = 0.0498). The magnitude of asymmetry was much greater in subjects compared 
      with controls (P = 0.0004). There was no association between the degree of 
      GCL-IPL thinning and the mean deviation on automated VF testing. A moderate 
      correlation (R = 0.782, P = 0.004) between the magnitude of thinning and latency 
      from onset of retrogeniculate injury was observed only after excluding patients 
      beyond a cutoff point of 150 months. CONCLUSIONS: This data provides compelling 
      new evidence of retrograde transsynaptic degeneration causing retinal ganglion 
      cell loss after postgeniculate visual pathway injury.
FAU - Mitchell, Jamie R
AU  - Mitchell JR
AD  - Departments of Ophthalmology (JM, CO, MD), Radiology (AJT), and Neurology (MD), 
      Weill Cornell Medical College, New York, New York.
FAU - Oliveira, Cristiano
AU  - Oliveira C
FAU - Tsiouris, Apostolos J
AU  - Tsiouris AJ
FAU - Dinkin, Marc J
AU  - Dinkin MJ
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Neuroophthalmol
JT  - Journal of neuro-ophthalmology : the official journal of the North American 
      Neuro-Ophthalmology Society
JID - 9431308
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Atrophy/etiology/pathology
MH  - Female
MH  - Hemianopsia/complications/*pathology
MH  - Humans
MH  - Longitudinal Studies
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Nerve Fibers/*pathology
MH  - Retinal Ganglion Cells/*pathology
MH  - Retrospective Studies
MH  - Tomography, Optical Coherence
MH  - Visual Field Tests
MH  - Visual Pathways/pathology
MH  - Young Adult
EDAT- 2015/06/03 06:00
MHDA- 2016/08/25 06:00
CRDT- 2015/06/03 06:00
PHST- 2015/06/03 06:00 [entrez]
PHST- 2015/06/03 06:00 [pubmed]
PHST- 2016/08/25 06:00 [medline]
AID - 10.1097/WNO.0000000000000268 [doi]
PST - ppublish
SO  - J Neuroophthalmol. 2015 Dec;35(4):353-9. doi: 10.1097/WNO.0000000000000268.