PMID- 26036286
OWN - NLM
STAT- MEDLINE
DCOM- 20160414
LR  - 20220409
IS  - 1742-7843 (Electronic)
IS  - 1742-7835 (Linking)
VI  - 117
IP  - 5
DP  - 2015 Nov
TI  - Hyperhomocysteinemia: Impact on Neurodegenerative Diseases.
PG  - 287-96
LID - 10.1111/bcpt.12424 [doi]
AB  - Neurodegenerative diseases are the diseases of the central nervous system with 
      various aetiology and symptoms. Dementia, Alzheimer's disease (AD), Parkinson's 
      disease (PD) and autism are some examples of neurodegenerative diseases. 
      Hyperhomocysteinemia (Hhcy) is considered to be an independent risk factor for 
      numerous pathological conditions under neurodegenerative diseases. Along with 
      genetic factors that are the prime cause of homocysteine (Hcy) imbalance, the 
      nutritional and hormonal factors are also contributing to high Hcy levels in the 
      body. Numerous clinical and epidemiological data confirm the direct correlation 
      of Hcy levels in the body and generation of different types of central nervous 
      system disorders, cardiovascular diseases, cancer and others. Till now, it is 
      difficult to say whether homocysteine is the cause of the disease or whether it 
      is one of the impacts of the diseases. However, Hhcy is a surrogate marker of 
      vitamin B deficiency and is a neurotoxic agent. This Mini Review will give an 
      overview of how far research has gone into understanding the homocysteine 
      imbalance with prognostic, causative and preventive measures in treating 
      neurodegenerative diseases.
CI  - (c) 2015 Nordic Association for the Publication of BCPT (former Nordic 
      Pharmacological Society).
FAU - Sharma, Meenakshi
AU  - Sharma M
AD  - Dr. B. R. Ambedkar Centre for Biomedical Research, University of Delhi, Delhi, 
      India.
AD  - Chapman University School of Pharmacy, Harry and Diane Rinker Health Science 
      Campus, Irvine, CA, USA.
FAU - Tiwari, Manisha
AU  - Tiwari M
AD  - Dr. B. R. Ambedkar Centre for Biomedical Research, University of Delhi, Delhi, 
      India.
FAU - Tiwari, Rakesh Kumar
AU  - Tiwari RK
AD  - Chapman University School of Pharmacy, Harry and Diane Rinker Health Science 
      Campus, Irvine, CA, USA.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20150619
PL  - England
TA  - Basic Clin Pharmacol Toxicol
JT  - Basic & clinical pharmacology & toxicology
JID - 101208422
RN  - 0 (Biomarkers)
RN  - 0LVT1QZ0BA (Homocysteine)
SB  - IM
MH  - Animals
MH  - Biomarkers/blood
MH  - Homocysteine/*blood
MH  - Humans
MH  - *Hyperhomocysteinemia/blood/diagnosis/epidemiology/therapy
MH  - *Neurodegenerative Diseases/blood/diagnosis/epidemiology/therapy
MH  - Nutritional Status
MH  - Prognosis
MH  - Risk Factors
MH  - Vitamin B Deficiency/blood/epidemiology
EDAT- 2015/06/04 06:00
MHDA- 2016/04/15 06:00
CRDT- 2015/06/04 06:00
PHST- 2015/03/01 00:00 [received]
PHST- 2015/05/19 00:00 [accepted]
PHST- 2015/06/04 06:00 [entrez]
PHST- 2015/06/04 06:00 [pubmed]
PHST- 2016/04/15 06:00 [medline]
AID - 10.1111/bcpt.12424 [doi]
PST - ppublish
SO  - Basic Clin Pharmacol Toxicol. 2015 Nov;117(5):287-96. doi: 10.1111/bcpt.12424. 
      Epub 2015 Jun 19.