PMID- 26036759
OWN - NLM
STAT- MEDLINE
DCOM- 20160406
LR  - 20181113
IS  - 1423-0380 (Electronic)
IS  - 1010-4283 (Linking)
VI  - 36
IP  - 11
DP  - 2015 Nov
TI  - Clinical significance of CUL4A in human prostate cancer.
PG  - 8553-8
LID - 10.1007/s13277-015-3580-2 [doi]
AB  - Aberrant expression of the Cullin 4A (CUL4A) is found in many tumor types, but 
      the functions and mechanism of CUL4A in prostate cancer (PCa) development and 
      progression remain largely unknown. The aim of this study was to investigate the 
      possible role of CUL4A in prostate tumorigenesis. Immunohistochemistry was used 
      to examine CUL4A expression in human PCa tissues and BPH tissues. Cell 
      proliferation was assessed by MTT, and migration and invasion were analyzed by 
      Transwell and Matrigel assays after CUL4A knockdown in PCa in vitro. The results 
      showed that CUL4A protein was overexpressed in 86.21 % of PCa tissues. CUL4A 
      knockdown with siRNA in PCa cells decreased cell proliferation, migration, and 
      invasion. Mechanistically, CUL4A could modulate the expression of P53 in PCa 
      cells. Our results indicate that CUL4A overexpression play an oncogenic role in 
      the pathogenesis of PCa, and CUL4A may be a potential therapeutic target for PCa.
FAU - Liu, Gang
AU  - Liu G
AD  - Department of Urology, Affiliated Hospital of Weifang Medical University, No. 
      2428 Yuhe Road, Kuiwei District, Weifang, Shandong, China.
FAU - Zhu, Zengjun
AU  - Zhu Z
AD  - Department of Urology, Affiliated Hospital of Weifang Medical University, No. 
      2428 Yuhe Road, Kuiwei District, Weifang, Shandong, China. drzhzj6@163.com.
FAU - Lang, Fang
AU  - Lang F
AD  - Department of Urology, Affiliated Hospital of Weifang Medical University, No. 
      2428 Yuhe Road, Kuiwei District, Weifang, Shandong, China.
FAU - Li, Bao
AU  - Li B
AD  - Department of Urology, Affiliated Hospital of Weifang Medical University, No. 
      2428 Yuhe Road, Kuiwei District, Weifang, Shandong, China.
FAU - Gao, Dianjun
AU  - Gao D
AD  - Department of Urology, Affiliated Hospital of Weifang Medical University, No. 
      2428 Yuhe Road, Kuiwei District, Weifang, Shandong, China.
LA  - eng
PT  - Journal Article
PT  - Retracted Publication
DEP - 20150603
PL  - Netherlands
TA  - Tumour Biol
JT  - Tumour biology : the journal of the International Society for Oncodevelopmental 
      Biology and Medicine
JID - 8409922
RN  - 0 (CUL4A protein, human)
RN  - 0 (Cullin Proteins)
SB  - IM
RIN - Tumour Biol. 2017 Apr 20;:. PMID: 28792236
MH  - Carcinogenesis/*genetics
MH  - Cell Line, Tumor
MH  - Cell Proliferation/*genetics
MH  - Cullin Proteins/*biosynthesis/genetics
MH  - Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - Male
MH  - Prostatic Neoplasms/*genetics/pathology
OTO - NOTNLM
OT  - CUL4A
OT  - P53
OT  - Proliferation
OT  - Prostate cancer
OT  - Targeted therapy
EDAT- 2015/06/04 06:00
MHDA- 2016/04/07 06:00
CRDT- 2015/06/04 06:00
PHST- 2015/04/21 00:00 [received]
PHST- 2015/05/15 00:00 [accepted]
PHST- 2015/06/04 06:00 [entrez]
PHST- 2015/06/04 06:00 [pubmed]
PHST- 2016/04/07 06:00 [medline]
AID - 10.1007/s13277-015-3580-2 [pii]
AID - 10.1007/s13277-015-3580-2 [doi]
PST - ppublish
SO  - Tumour Biol. 2015 Nov;36(11):8553-8. doi: 10.1007/s13277-015-3580-2. Epub 2015 
      Jun 3.