PMID- 26037098
OWN - NLM
STAT- MEDLINE
DCOM- 20151120
LR  - 20161125
IS  - 1879-1514 (Electronic)
IS  - 0166-445X (Linking)
VI  - 165
DP  - 2015 Aug
TI  - Developmental retardation, reduced fecundity, and modulated expression of the 
      defensome in the intertidal copepod Tigriopus japonicus exposed to BDE-47 and 
      PFOS.
PG  - 136-43
LID - S0166-445X(15)00171-X [pii]
LID - 10.1016/j.aquatox.2015.05.022 [doi]
AB  - 2,2',4,4'-tetrabromodiphenyl ether (BDE-47) and perfluorooctane sulfonate (PFOS) 
      are widely dispersed persistent organic pollutants (POPs) in the marine 
      ecosystem. However, their toxic effects on marine organisms are still poorly 
      understood. In this study, we investigated the effects of BDE-47 and PFOS on 
      development and reproduction at the organismal level and reactive oxygen species 
      (ROS) production and gene expression patterns of the defensome at the cellular 
      level in the intertidal copepod Tigriopus japonicus. In copepods exposed to 
      BDE-47 and PFOS, we observed developmental retardation and reduced fecundity, 
      suggesting repercussions on in vivo endpoints through alterations to the normal 
      molting and reproduction system of T. japonicus. BDE-47 and PFOS increased levels 
      of ROS in T. japonicus in a concentration-dependent manner, indicating that POPs 
      can induce oxidative stress through the generation of ROS. Additionally, 
      transcript profiles of genes related to detoxification (e.g., CYPs), antioxidant 
      functions (e.g., GST- sigma, catalase, MnSOD), apoptosis (e.g., p53, Rb), and 
      cellular proliferation (e.g., PCNA) were modulated over 72h in response to BDE-47 
      (120mug/L) and PFOS (1000mug/L). These findings indicate that BDE-47 and PFOS can 
      induce oxidative stress-mediated DNA damage repair systems with transcriptional 
      regulation of detoxification, antioxidant, and apoptosis-related genes, resulting 
      in developmental retardation and reduced fecundity in the copepod T. japonicus.
CI  - Copyright (c) 2015 Elsevier B.V. All rights reserved.
FAU - Han, Jeonghoon
AU  - Han J
AD  - Department of Biological Science, College of Science, Sungkyunkwan University, 
      Suwon 440-746, South Korea.
FAU - Won, Eun-Ji
AU  - Won EJ
AD  - Department of Biological Science, College of Science, Sungkyunkwan University, 
      Suwon 440-746, South Korea.
FAU - Lee, Min-Chul
AU  - Lee MC
AD  - Department of Biological Science, College of Science, Sungkyunkwan University, 
      Suwon 440-746, South Korea.
FAU - Seo, Jung Soo
AU  - Seo JS
AD  - Pathology Team, National Fisheries Research & Development Institute, Busan 
      619-902, South Korea.
FAU - Lee, Su-Jae
AU  - Lee SJ
AD  - Department of Life Science, College of Natural Sciences, Hanyang University, 
      Seoul 133-791, South Korea.
FAU - Lee, Jae-Seong
AU  - Lee JS
AD  - Department of Biological Science, College of Science, Sungkyunkwan University, 
      Suwon 440-746, South Korea. Electronic address: jslee2@skku.edu.
LA  - eng
GR  - 5R01ES020921/ES/NIEHS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20150527
PL  - Netherlands
TA  - Aquat Toxicol
JT  - Aquatic toxicology (Amsterdam, Netherlands)
JID - 8500246
RN  - 0 (Alkanesulfonic Acids)
RN  - 0 (Fluorocarbons)
RN  - 0 (Halogenated Diphenyl Ethers)
RN  - 0 (Proteome)
RN  - 0 (Reactive Oxygen Species)
RN  - 0 (Water Pollutants, Chemical)
RN  - 0N97R5X10X (2,2',4,4'-tetrabromodiphenyl ether)
RN  - 9H2MAI21CL (perfluorooctane sulfonic acid)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
RN  - EC 1.15.1.1 (superoxide dismutase 2)
SB  - IM
MH  - Alkanesulfonic Acids/*toxicity
MH  - Animals
MH  - Copepoda/*drug effects/genetics/growth & development
MH  - Environmental Exposure
MH  - Fluorocarbons/*toxicity
MH  - Gene Expression Regulation/*drug effects
MH  - Halogenated Diphenyl Ethers/*toxicity
MH  - Oxidative Stress/drug effects/genetics
MH  - Proteome/genetics
MH  - Reactive Oxygen Species/metabolism
MH  - Reproduction/drug effects
MH  - Superoxide Dismutase/genetics/metabolism
MH  - Water Pollutants, Chemical/toxicity
OTO - NOTNLM
OT  - Copepod
OT  - Developmental retardation
OT  - Persistent organic pollutants
OT  - Reactive oxygen species
OT  - Reduced fecundity
OT  - Tigriopus japonicus
EDAT- 2015/06/04 06:00
MHDA- 2015/12/15 06:00
CRDT- 2015/06/04 06:00
PHST- 2015/04/08 00:00 [received]
PHST- 2015/05/21 00:00 [revised]
PHST- 2015/05/25 00:00 [accepted]
PHST- 2015/06/04 06:00 [entrez]
PHST- 2015/06/04 06:00 [pubmed]
PHST- 2015/12/15 06:00 [medline]
AID - S0166-445X(15)00171-X [pii]
AID - 10.1016/j.aquatox.2015.05.022 [doi]
PST - ppublish
SO  - Aquat Toxicol. 2015 Aug;165:136-43. doi: 10.1016/j.aquatox.2015.05.022. Epub 2015 
      May 27.