PMID- 26037355
OWN - NLM
STAT- MEDLINE
DCOM- 20150814
LR  - 20150603
IS  - 1003-9406 (Print)
IS  - 1003-9406 (Linking)
VI  - 32
IP  - 3
DP  - 2015 Jun
TI  - [Morphology and pathogenesis of 47, XYY/47, XY, +mar identified in patients with 
      super male syndrome].
PG  - 378-80
LID - 10.3760/cma.j.issn.1003-9406.2015.03.017 [doi]
AB  - OBJECTIVE: To explore the source and morphology of supernumerary markers from 
      patients with 47,XYY/47,XY, +mar and supermale syndrome. METHODS: Conventional 
      GTG banded karyotyping and dual-color fluorescence in situ hybridization (FISH) 
      were performed on 21 such patients. RESULTS: Among these cases, 18 had their 
      small supernumerary marker derived from the Y chromosome. Three were derived from 
      autosomal chromosomes. Those derived from Y chromosome were small fragments with 
      centromeres, while those derived from autosomes were in the ring form. 
      CONCLUSION: In children with supermale syndrome and 47,XYY/47,XY,+ mar, the 
      supernumerary marker chromosomes primarily derive from sex chromosomes. These 
      small chromosomes mainly have the forms of small segments with centromeres or 
      rings. For such children, molecular cytogenetic analysis can facilitate genetic 
      counseling and prenatal diagnosis.
FAU - Song, Yinsen
AU  - Song Y
AD  - Zhengzhou Children's Hospital, Zhengzhou, Henan 450053, P.R.China. 
      df13607670608@163.com.
FAU - Jin, Xiangdong
AU  - Jin X
FAU - Zhao, Ding
AU  - Zhao D
FAU - Guo, Zhenxin
AU  - Guo Z
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhonghua Yi Xue Yi Chuan Xue Za Zhi
JT  - Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese 
      journal of medical genetics
JID - 9425197
RN  - 47, XYY syndrome
SB  - IM
MH  - Adolescent
MH  - Child
MH  - Child, Preschool
MH  - Chromosome Aberrations
MH  - Chromosome Banding
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Infant
MH  - Male
MH  - Sex Chromosome Disorders/*genetics
MH  - XYY Karyotype/*genetics
EDAT- 2015/06/04 06:00
MHDA- 2015/08/15 06:00
CRDT- 2015/06/04 06:00
PHST- 2015/06/04 06:00 [entrez]
PHST- 2015/06/04 06:00 [pubmed]
PHST- 2015/08/15 06:00 [medline]
AID - 940632082 [pii]
AID - 10.3760/cma.j.issn.1003-9406.2015.03.017 [doi]
PST - ppublish
SO  - Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2015 Jun;32(3):378-80. doi: 
      10.3760/cma.j.issn.1003-9406.2015.03.017.