PMID- 26038393
OWN - NLM
STAT- MEDLINE
DCOM- 20151015
LR  - 20150722
IS  - 1097-6817 (Electronic)
IS  - 0194-5998 (Linking)
VI  - 153
IP  - 2
DP  - 2015 Aug
TI  - The Minimal Clinically Important Difference in Vestibular Schwannoma 
      Quality-of-Life Assessment: An Important Step beyond P < .05.
PG  - 202-8
LID - 10.1177/0194599815585508 [doi]
AB  - OBJECTIVE: Several studies have demonstrated small but statistically significant 
      differences in quality-of-life (QOL) scores among vestibular schwannoma (VS) 
      treatment modalities. However, does a several-point difference on a 100-point 
      scale really matter? The minimal clinically important difference (MCID)-defined 
      as the smallest difference in scores that patients perceive as important and that 
      could lead to a change in management-was developed to answer this important 
      question. While the MCID has been determined for QOL measures used in other 
      diseases, it remains undefined in the VS literature. STUDY DESIGN: Distribution- 
      and anchor-based techniques were utilized to define the MCID for the Penn 
      Acoustic Neuroma Quality of Life (PANQOL) and 36-Item Short Form Health Survey 
      (SF-36). SETTING: Two academic referral centers. PATIENTS: Patients with VS (N = 
      538). INTERVENTION: Cross-sectional postal survey. MAIN OUTCOME MEASURES: MCID 
      for PANQOL domains and total score and SF-36 Physical and Mental Health Component 
      Summary scores. RESULTS: The MCID (median, interquartile range) for the PANQOL 
      total score was 11 points (10-12); the MCIDs for individual domains were as 
      follows: hearing, 6 (5-8); balance, 16 (14-19); facial, 10 (no interquartile 
      range); pain, 11 (10-13); energy, 13 (10-17); anxiety, 11 (5-22); and general, 15 
      (11-19). The MCID was 7 points (6-11) for the SF-36 Mental Health Component 
      Summary score and 8 points (6-10) for the Physical Health Component Summary 
      score. CONCLUSIONS: The MCIDs determined in the current study generally exceed 
      differences reported in previous prospective studies, in which conclusions about 
      QOL benefit (or harm) among VS treatment modalities were based on statistical 
      significance alone. Moving forward, these MCIDs should be considered when 
      interpreting results of VS QOL studies.
CI  - (c) American Academy of Otolaryngology-Head and Neck Surgery Foundation 2015.
FAU - Carlson, Matthew L
AU  - Carlson ML
AD  - Department of Otolaryngology-Head and Neck Surgery, Mayo Clinic School of 
      Medicine, Rochester, Minnesota, USA carlson.matthew@mayo.edu.
FAU - Tveiten, Oystein Vesterli
AU  - Tveiten OV
AD  - Department of Neurosurgery, Bergen University Hospital, Bergen, Norway.
FAU - Yost, Kathleen J
AU  - Yost KJ
AD  - Department of Epidemiology, Mayo Clinic School of Medicine, Rochester, Minnesota, 
      USA.
FAU - Lohse, Christine M
AU  - Lohse CM
AD  - Department of Health Sciences Research, Biomedical Statistics and Informatics, 
      Mayo Clinic School of Medicine, Rochester, Minnesota, USA.
FAU - Lund-Johansen, Morten
AU  - Lund-Johansen M
AD  - Department of Neurosurgery, Bergen University Hospital, Bergen, Norway Institute 
      of Surgical Sciences, University of Bergen, Bergen, Norway.
FAU - Link, Michael J
AU  - Link MJ
AD  - Department of Neurologic Surgery, Mayo Clinic School of Medicine, Rochester, 
      Minnesota, USA.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150602
PL  - England
TA  - Otolaryngol Head Neck Surg
JT  - Otolaryngology--head and neck surgery : official journal of American Academy of 
      Otolaryngology-Head and Neck Surgery
JID - 8508176
SB  - IM
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Neuroma, Acoustic/*psychology
MH  - *Quality of Life
OTO - NOTNLM
OT  - acoustic neuroma
OT  - cerebellopontine angle
OT  - gamma knife radiosurgery
OT  - microsurgery
OT  - minimal clinically important difference
OT  - patient-reported outcome measures
OT  - quality of life
OT  - stereotactic radiosurgery
OT  - vestibular schwannoma
EDAT- 2015/06/04 06:00
MHDA- 2015/10/16 06:00
CRDT- 2015/06/04 06:00
PHST- 2014/12/18 00:00 [received]
PHST- 2015/04/15 00:00 [accepted]
PHST- 2015/06/04 06:00 [entrez]
PHST- 2015/06/04 06:00 [pubmed]
PHST- 2015/10/16 06:00 [medline]
AID - 0194599815585508 [pii]
AID - 10.1177/0194599815585508 [doi]
PST - ppublish
SO  - Otolaryngol Head Neck Surg. 2015 Aug;153(2):202-8. doi: 10.1177/0194599815585508. 
      Epub 2015 Jun 2.