PMID- 26038429
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150603
LR  - 20200506
IS  - 2222-1751 (Print)
IS  - 2222-1751 (Electronic)
IS  - 2222-1751 (Linking)
VI  - 1
IP  - 9
DP  - 2012 Sep
TI  - Understanding the T cell immune response in SARS coronavirus infection.
PG  - e23
LID - 10.1038/emi.2012.26 [doi]
AB  - The severe acute respiratory syndrome (SARS) epidemic started in late 2002 and 
      swiftly spread across 5 continents with a mortality rate of around 10%. Although 
      the epidemic was eventually controlled through the implementation of strict 
      quarantine measures, there continues a need to investigate the SARS coronavirus 
      (SARS-CoV) and develop interventions should it re-emerge. Numerous studies have 
      shown that neutralizing antibodies against the virus can be found in patients 
      infected with SARS-CoV within days upon the onset of illness and lasting up to 
      several months. In contrast, there is little data on the kinetics of T cell 
      responses during SARS-CoV infection and little is known about their role in the 
      recovery process. However, recent studies in mice suggest the importance of T 
      cells in viral clearance during SARS-CoV infection. Moreover, a growing number of 
      studies have investigated the memory T cell responses in recovered SARS patients. 
      This review covers the available literature on the emerging importance of T cell 
      responses in SARS-CoV infection, particularly on the mapping of cytotoxic T 
      lymphocyte (CTL) epitopes, longevity, polyfunctionality and human leukocyte 
      antigen (HLA) association as well as their potential implications on treatment 
      and vaccine development.
FAU - Janice Oh, Hsueh-Ling
AU  - Janice Oh HL
AD  - Singapore Immunology Network, Agency of Science Technology and Research (AStar) , 
      Singapore 138648, Singapore ; Institute of Molecular and Cell Biology, Agency of 
      Science Technology and Research (A*Star) , Singapore 138673, Singapore.
FAU - Ken-En Gan, Samuel
AU  - Ken-En Gan S
AD  - Bioinformatics Institute, Agency of Science Technology and Research (AStar) , 
      Singapore 138671, Singapore.
FAU - Bertoletti, Antonio
AU  - Bertoletti A
AD  - Singapore Institute for Clinical Sciences, Agency of Science Technology and 
      Research (AStar) , Singapore 117609, Singapore ; Program of Emerging Viral 
      Diseases, Duke-NUS Graduate Medical School , Singapore 169857, Singapore ; 
      Department of Medicine, Yong Loo Lin School of Medicine, National University of 
      Singapore , Singapore 119228, Singapore.
FAU - Tan, Yee-Joo
AU  - Tan YJ
AD  - Institute of Molecular and Cell Biology, Agency of Science Technology and 
      Research (AStar) , Singapore 138673, Singapore ; Department of Microbiology, Yong 
      Loo Lin School of Medicine, National University of Singapore , Singapore 117597, 
      Singapore.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20120905
PL  - United States
TA  - Emerg Microbes Infect
JT  - Emerging microbes & infections
JID - 101594885
PMC - PMC3636424
OTO - NOTNLM
OT  - CD4+
OT  - CD8+
OT  - SARS
OT  - T-cell immunity
OT  - coronavirus
OT  - epitope
OT  - virus clearance
EDAT- 2012/09/01 00:00
MHDA- 2012/09/01 00:01
PMCR- 2012/09/01
CRDT- 2015/06/04 06:00
PHST- 2012/05/10 00:00 [received]
PHST- 2012/07/02 00:00 [revised]
PHST- 2012/07/06 00:00 [accepted]
PHST- 2015/06/04 06:00 [entrez]
PHST- 2012/09/01 00:00 [pubmed]
PHST- 2012/09/01 00:01 [medline]
PHST- 2012/09/01 00:00 [pmc-release]
AID - emi201226 [pii]
AID - 10.1038/emi.2012.26 [doi]
PST - ppublish
SO  - Emerg Microbes Infect. 2012 Sep;1(9):e23. doi: 10.1038/emi.2012.26. Epub 2012 Sep 
      5.