PMID- 26039281
OWN - NLM
STAT- MEDLINE
DCOM- 20170918
LR  - 20181202
IS  - 1600-0501 (Electronic)
IS  - 0905-7161 (Linking)
VI  - 27
IP  - 5
DP  - 2016 May
TI  - Bone formation in mono cortical mandibular critical size defects after 
      augmentation with two synthetic nanostructured and one xenogenous hydroxyapatite 
      bone substitute - in vivo animal study.
PG  - 597-603
LID - 10.1111/clr.12628 [doi]
AB  - OBJECTIVES: Healing characteristics as well as level of tissue integration and 
      degradation of two different nanostructured hydroxyapatite bone substitute 
      materials (BSM) in comparison with a deproteinized hydroxyapatite bovine BSM were 
      evaluated in an in vivo animal experiment. MATERIAL AND METHODS: In the posterior 
      mandible of 18 minipigs, bilateral mono cortical critical size bone defects were 
      created. Randomized augmentation procedures with NanoBone((R)) (NHA1), Ostim((R)) 
      (NHA2) or Bio-Oss((R)) (DBBM) were conducted (each material n = 12). Samples were 
      analyzed after five (each material n = 6) and 8 months (each material n = 6). 
      Defect healing, formation of soft tissue and bone as well as the amount of 
      remaining respective BSM were quantified both macro- and microscopically. 
      RESULTS: For NHA2, the residual bone defect after 5 weeks was significantly less 
      compared to NHA1 or DBBM. There was no difference in residual BSM between NHA1 
      and DBBM, but the amount in NHA2 was significantly lower. NHA2 also showed the 
      least amount of soft tissue and the highest amount of new bone after 5 weeks. 
      Eight months after implantation, no significant differences in the amount of 
      residual bone defects, in soft tissue or in bone formation were detected between 
      the groups. Again, NHA2 showed significant less residual material than NHA1 and 
      DBBM. DISCUSSION: We observed non-significant differences in the biological hard 
      tissue response of NHA1 and DBBM. The water-soluble NHA2 initially induced an 
      increased amount of new bone but was highly compressed which may have a negative 
      effect in less stable augmentations of the jaw.
CI  - (c) 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Dau, Michael
AU  - Dau M
AD  - Department of Oral and Maxillofacial Surgery, University of Rostock, Rostock, 
      Germany.
AD  - Department of Oral and Maxillofacial Surgery, Federal Army Hospital 
      Hamburg-Wandsbek, Hamburg, Germany.
FAU - Kammerer, Peer W
AU  - Kammerer PW
AD  - Department of Oral and Maxillofacial Surgery, University of Rostock, Rostock, 
      Germany.
AD  - Department of Oral and Maxillofacial Surgery, Federal Army Hospital 
      Hamburg-Wandsbek, Hamburg, Germany.
FAU - Henkel, Kai-Olaf
AU  - Henkel KO
AD  - Department of Oral and Maxillofacial Surgery, Federal Army Hospital 
      Hamburg-Wandsbek, Hamburg, Germany.
FAU - Gerber, Thomas
AU  - Gerber T
AD  - Department of Physics, Faculty of Mathematics and Natural Sciences, Rostock 
      University, Rostock, Germany.
FAU - Frerich, Bernhard
AU  - Frerich B
AD  - Department of Oral and Maxillofacial Surgery, University of Rostock, Rostock, 
      Germany.
AD  - Department of Oral and Maxillofacial Surgery, Federal Army Hospital 
      Hamburg-Wandsbek, Hamburg, Germany.
FAU - Gundlach, Karsten K H
AU  - Gundlach KK
AD  - Department of Oral and Maxillofacial Surgery, University of Rostock, Rostock, 
      Germany.
AD  - Department of Oral and Maxillofacial Surgery, Federal Army Hospital 
      Hamburg-Wandsbek, Hamburg, Germany.
LA  - eng
PT  - Journal Article
DEP - 20150603
PL  - Denmark
TA  - Clin Oral Implants Res
JT  - Clinical oral implants research
JID - 9105713
RN  - 0 (Bio-Oss)
RN  - 0 (Bone Substitutes)
RN  - 0 (Drug Combinations)
RN  - 0 (Hydroxyapatites)
RN  - 0 (Minerals)
RN  - 0 (NanoBone)
RN  - 7631-86-9 (Silicon Dioxide)
RN  - 91D9GV0Z28 (Durapatite)
MH  - Animals
MH  - Bone Regeneration
MH  - *Bone Substitutes
MH  - Cattle
MH  - Drug Combinations
MH  - Durapatite/chemistry
MH  - Hydroxyapatites/chemistry
MH  - Mandible/*surgery
MH  - Minerals/chemistry
MH  - *Osteogenesis
MH  - Random Allocation
MH  - Silicon Dioxide/chemistry
MH  - Swine
MH  - Swine, Miniature
MH  - *Wound Healing
OTO - NOTNLM
OT  - animal experiment
OT  - bone regeneration
OT  - bone substitute
OT  - deproteinized hydroxyapatite bovine
OT  - mandibular augmentation
OT  - minipig
OT  - mono cortical critical size defect
OT  - nanostructured hydroxyapatite
EDAT- 2015/06/04 06:00
MHDA- 2017/09/19 06:00
CRDT- 2015/06/04 06:00
PHST- 2015/05/06 00:00 [accepted]
PHST- 2015/06/04 06:00 [entrez]
PHST- 2015/06/04 06:00 [pubmed]
PHST- 2017/09/19 06:00 [medline]
AID - 10.1111/clr.12628 [doi]
PST - ppublish
SO  - Clin Oral Implants Res. 2016 May;27(5):597-603. doi: 10.1111/clr.12628. Epub 2015 
      Jun 3.