PMID- 26039722
OWN - NLM
STAT- MEDLINE
DCOM- 20160222
LR  - 20181113
IS  - 1531-7056 (Electronic)
IS  - 0267-1379 (Print)
IS  - 0267-1379 (Linking)
VI  - 31
IP  - 4
DP  - 2015 Jul
TI  - Proton pump inhibitor-responsive oesophageal eosinophilia and eosinophilic 
      oesophagitis: more similarities than differences.
PG  - 309-15
LID - 10.1097/MOG.0000000000000185 [doi]
AB  - PURPOSE OF REVIEW: The purpose of this study is to discuss the clinical, 
      endoscopic and histologic features, pathogenesis and disease mechanisms of proton 
      pump inhibitor (PPI)-responsive oesophageal eosinophilia (PPI-REE), and to 
      highlight similarities and differences with eosinophilic oesophagitis (EoE). 
      RECENT FINDINGS: PPI-REE is a condition in which patients have clinical and 
      histologic findings similar to EoE, but achieve complete remission with PPI 
      treatment. More than one-third of patients who have oesophageal symptoms 
      associated with oesophageal eosinophilia respond to PPI treatment. Emerging data 
      elucidating the pathogenesis of PPI-REE have shown that Th2-related inflammatory 
      factors such as interleukin (IL)-13, IL-5, eotaxin-3 and major basic protein 
      (MBP) are elevated in PPI-REE, similar to EoE. PPI-REE also shares a genetic 
      expression signature with EoE that reverses with PPI treatment. Mechanisms 
      proposed to explain the PPI response include an acid-independent, 
      anti-inflammatory action of PPIs and PPI-induced restoration of oesophageal 
      barrier function. SUMMARY: Multiple features of PPI-REE overlap extensively with 
      EoE. This raises the question of whether PPI-REE is merely a subtype of EoE 
      rather than an independent condition. This similarity may have future 
      implications for algorithms informing evaluation and treatment of oesophageal 
      eosinophilia.
FAU - Eluri, Swathi
AU  - Eluri S
AD  - aCenter for Esophageal Diseases and Swallowing bCenter for Gastrointestinal 
      Biology and Disease, Division of Gastroenterology and Hepatology, Department of 
      Medicine, University of North Carolina School of Medicine, Chapel Hill, North 
      Carolina, USA.
FAU - Dellon, Evan S
AU  - Dellon ES
LA  - eng
GR  - K23 DK090073/DK/NIDDK NIH HHS/United States
GR  - U54AI117804/AI/NIAID NIH HHS/United States
GR  - R01 DK101856/DK/NIDDK NIH HHS/United States
GR  - K23DK090073/DK/NIDDK NIH HHS/United States
GR  - U54 AI117804/AI/NIAID NIH HHS/United States
GR  - T32DK007634/DK/NIDDK NIH HHS/United States
GR  - R01DK101856/DK/NIDDK NIH HHS/United States
GR  - T32 DK007634/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
PL  - United States
TA  - Curr Opin Gastroenterol
JT  - Current opinion in gastroenterology
JID - 8506887
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
MH  - Eosinophilic Esophagitis/diagnosis/*drug therapy/genetics
MH  - Esophageal pH Monitoring/methods
MH  - Esophagoscopy/methods
MH  - Gastroesophageal Reflux/diagnosis
MH  - Gene Expression Regulation/drug effects
MH  - Humans
MH  - Prognosis
MH  - Proton Pump Inhibitors/pharmacology/*therapeutic use
PMC - PMC4586084
MID - NIHMS723711
COIS- Conflict of Interest: Eluri - none Dellon - none pertaining to this article.
EDAT- 2015/06/04 06:00
MHDA- 2016/02/24 06:00
PMCR- 2016/07/01
CRDT- 2015/06/04 06:00
PHST- 2015/06/04 06:00 [entrez]
PHST- 2015/06/04 06:00 [pubmed]
PHST- 2016/02/24 06:00 [medline]
PHST- 2016/07/01 00:00 [pmc-release]
AID - 00001574-201507000-00007 [pii]
AID - 10.1097/MOG.0000000000000185 [doi]
PST - ppublish
SO  - Curr Opin Gastroenterol. 2015 Jul;31(4):309-15. doi: 
      10.1097/MOG.0000000000000185.