PMID- 26039911
OWN - NLM
STAT- MEDLINE
DCOM- 20150923
LR  - 20221207
IS  - 1807-3107 (Electronic)
IS  - 1806-8324 (Linking)
VI  - 29
DP  - 2015
TI  - Supragingival biofilm control and systemic inflammation in patients with type 2 
      diabetes mellitus.
LID - S1806-83242015000100266 [pii]
LID - 10.1590/1807-3107BOR-2015.vol29.0071 [doi]
AB  - The objective of this study was to evaluate the effect of strict supragingival 
      biofilm control on serum inflammatory markers and on periodontal clinical 
      parameters in type 2 diabetes mellitus (T2DM) patients with chronic severe 
      periodontitis. Twenty-four individuals with T2DM and periodontitis were randomly 
      allocated to two treatment groups. The supragingival therapy group (ST, n = 12) 
      received supragingival scaling, whereas the intensive therapy group (IT, n = 12) 
      underwent supra- and subgingival scaling, as well as root planing. Patients from 
      both groups received professional oral hygiene instructions every month. Data 
      regarding visible plaque index (VPI), gingival bleeding index (GBI), bleeding on 
      probing (BOP), probing pocket depth (PPD), clinical attachment level (CAL), serum 
      levels of interleukin (IL)-6, IL-17A, IL-8, tumor necrosis factor alpha (TNF-alpha), 
      monocyte chemoattractant protein (MCP)-1 enzyme-linked immunosorbent assay 
      (ELISA), and glycated hemoglobin (HbA1c) levels were obtained at baseline and at 
      6 months post-therapy. Both therapies resulted in the improvement of almost all 
      clinical periodontal parameters (p < 0.05). There were no differences in TNF-alpha, 
      IL-8, IL-17A and HbA1c levels in either group (p > 0.05), between the two 
      periods. However, MCP-1 levels were significantly reduced in both the ST (p = 
      0.034) and the IT (p = 0.016) groups, whereas the serum IL-6 levels were 
      significantly reduced only in the IT group (p = 0.001). Strict control of 
      supragingival biofilm has a limited effect on systemic inflammatory markers, and 
      a moderate effect on periodontal clinical parameters.
FAU - Artese, Hilana Paula Carillo
AU  - Artese HP
AD  - Department of Periodontics, School of Dentistry, Universidade de Sao Paulo, Sao 
      Paulo, SP, Brazil.
FAU - Longo, Priscila Larcher
AU  - Longo PL
AD  - Department of Microbiology, Institute of Biomedical Sciences, Universidade de Sao 
      Paulo, Sao Paulo, SP, Brazil.
FAU - Gomes, Giovane Hisse
AU  - Gomes GH
AD  - Department of Periodontics, School of Dentistry, Universidade de Sao Paulo, Sao 
      Paulo, SP, Brazil.
FAU - Mayer, Marcia Pinto Alves
AU  - Mayer MP
AD  - Department of Microbiology, Institute of Biomedical Sciences, Universidade de Sao 
      Paulo, Sao Paulo, SP, Brazil.
FAU - Romito, Giuseppe Alexandre
AU  - Romito GA
AD  - Department of Periodontics, School of Dentistry, Universidade de Sao Paulo, Sao 
      Paulo, SP, Brazil.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - Brazil
TA  - Braz Oral Res
JT  - Brazilian oral research
JID - 101307187
RN  - 0 (Biomarkers)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (Interleukins)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - *Biofilms
MH  - Biomarkers/blood
MH  - Chemokine CCL2/blood
MH  - Chronic Periodontitis/*blood/*therapy
MH  - Dental Scaling/*methods
MH  - Diabetes Mellitus, Type 2/*blood
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Gingiva/*microbiology
MH  - Glycated Hemoglobin/analysis
MH  - Humans
MH  - Interleukins/blood
MH  - Male
MH  - Middle Aged
MH  - Periodontal Index
MH  - Reference Values
MH  - Statistics, Nonparametric
MH  - Treatment Outcome
MH  - Tumor Necrosis Factor-alpha/blood
EDAT- 2015/06/04 06:00
MHDA- 2015/09/24 06:00
CRDT- 2015/06/04 06:00
PHST- 2014/09/23 00:00 [received]
PHST- 2015/01/28 00:00 [accepted]
PHST- 2015/06/04 06:00 [entrez]
PHST- 2015/06/04 06:00 [pubmed]
PHST- 2015/09/24 06:00 [medline]
AID - S1806-83242015000100266 [pii]
AID - 10.1590/1807-3107BOR-2015.vol29.0071 [doi]
PST - ppublish
SO  - Braz Oral Res. 2015;29:S1806-83242015000100266. doi: 
      10.1590/1807-3107BOR-2015.vol29.0071.