PMID- 26040207
OWN - NLM
STAT- MEDLINE
DCOM- 20160623
LR  - 20181113
IS  - 1435-232X (Electronic)
IS  - 1434-5161 (Linking)
VI  - 60
IP  - 11
DP  - 2015 Nov
TI  - Functional and genetic diversity of leukocyte immunoglobulin-like receptor and 
      implication for disease associations.
PG  - 703-8
LID - 10.1038/jhg.2015.64 [doi]
AB  - Human leukocyte immunoglobulin-like receptors (LILR) are a family of 11 
      functional genes encoding five activating (LILRA1, 2, 4-6), five inhibitory 
      (LILRB1-5) and one soluble (LILRA3) form. The number of LILR genes is conserved 
      among individuals, except for LILRA3 and LILRA6, which exhibit copy-number 
      variations. The LILR genes are rapidly evolving and showing large interspecies 
      differences, making it difficult to analyze the functions of LILR using an animal 
      model. LILRs are expressed on various cells such as lymphoid and myeloid cells 
      and the expression patterns are different from gene to gene. The LILR gene 
      expression and polymorphisms have been reported to be associated with autoimmune 
      and infectious diseases such as rheumatoid arthritis and cytomegalovirus 
      infection. Although human leukocyte antigen (HLA) class I is a well-characterized 
      ligand for some LILRs, non-HLA ligands have been increasingly identified in 
      recent years. LILRs have diverse functions, including the regulation of 
      inflammation, immune tolerance, cell differentiation and nervous system 
      plasticity. This review focuses on the genetic and functional diversity of the 
      LILR family.
FAU - Hirayasu, Kouyuki
AU  - Hirayasu K
AD  - Laboratory of Immunochemistry, WPI Immunology Frontier Research Center, Osaka 
      University, Osaka, Japan.
FAU - Arase, Hisashi
AU  - Arase H
AD  - Laboratory of Immunochemistry, WPI Immunology Frontier Research Center, Osaka 
      University, Osaka, Japan.
AD  - Department of Immunochemistry, Research Institute for Microbial Diseases, Osaka 
      University, Osaka, Japan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20150604
PL  - England
TA  - J Hum Genet
JT  - Journal of human genetics
JID - 9808008
RN  - 0 (Ligands)
RN  - 0 (Receptors, Immunologic)
SB  - IM
MH  - Animals
MH  - Gene Expression
MH  - Genetic Association Studies
MH  - Genetic Variation
MH  - Humans
MH  - Leukocytes/*immunology
MH  - Ligands
MH  - Multigene Family
MH  - Receptors, Immunologic/*genetics/metabolism
EDAT- 2015/06/05 06:00
MHDA- 2016/06/24 06:00
CRDT- 2015/06/05 06:00
PHST- 2015/04/27 00:00 [received]
PHST- 2015/05/08 00:00 [revised]
PHST- 2015/05/10 00:00 [accepted]
PHST- 2015/06/05 06:00 [entrez]
PHST- 2015/06/05 06:00 [pubmed]
PHST- 2016/06/24 06:00 [medline]
AID - jhg201564 [pii]
AID - 10.1038/jhg.2015.64 [doi]
PST - ppublish
SO  - J Hum Genet. 2015 Nov;60(11):703-8. doi: 10.1038/jhg.2015.64. Epub 2015 Jun 4.