PMID- 26040706
OWN - NLM
STAT- MEDLINE
DCOM- 20170418
LR  - 20170418
IS  - 1753-0407 (Electronic)
IS  - 1753-0407 (Linking)
VI  - 8
IP  - 4
DP  - 2016 Jul
TI  - Hospitalization and 1-year all-cause mortality in type 2 diabetic patients with 
      chronic kidney disease at Stages 1 and 2: Effect of mild anemia.
PG  - 502-7
LID - 10.1111/1753-0407.12318 [doi]
AB  - BACKGROUND: The effect of anemia in advanced chronic kidney disease (CKD) on 
      morbidity and mortality is known. The aim of the present study was to assess the 
      effect of mild anemia on hospitalization and 1-year all-cause mortality in type 2 
      diabetes mellitus (T2DM) patients with Stage 1 and 2 CKD. METHODS: Hospitalized 
      T2DM patients (n = 307) with a glomerular filtration rate >/= 60 mL/min per 
      1.73 m(2) and urinary albumin excretion > 30 mg/24 h (Stage 1 and 2 CKD) were 
      enrolled in the study and divided into two groups based on hemoglobin (Hb) 
      concentrations: those with (mean [ +/- SD] Hb 10.7 +/- 0.7 g/dL) and without (mean Hb 
      13.3 +/- 1.28 g/dL) anemia. RESULTS: There was no significant difference between 
      patients with and without anemia in terms of age, gender, body mass index, HbA1c, 
      and cardiovascular diseases. The mean length of hospitalization of the 130 anemic 
      and 177 non-anemic patients was 4.3 +/- 3.5 and 3.5 +/- 1.9 days, respectively 
      (P < 0.001). Twelve anemic patients died within 1 year, compared with three 
      patients without anemia (9.2% vs 1.7%, respectively; P = 0.002). After adjusting 
      for confounding variables, multivariate Cox regression analysis revealed that 
      mild anemia was significantly associated with 1-year all-cause mortality (hazard 
      ratio 2.15, 95% confidence interval 1.92-2.54; P = 0.033). CONCLUSIONS: Mild 
      anemia may increase the length of hospitalization and was associated with 1-year 
      all-cause mortality among hospitalized T2DM patients with Stage 1 and 2 CKD.
CI  - (c) 2015 Ruijin Hospital, Shanghai Jiaotong University School of Medicine and John 
      Wiley & Sons Australia, Ltd.
FAU - Nseir, William
AU  - Nseir W
AD  - Intenal Medicine Department, Holy Family Hospital, Nazareth, Israel.
AD  - Faculty of Medicine in the Galilee, Bar-Ilan University, Safed, Israel.
FAU - Artul, Suheil
AU  - Artul S
AD  - Division of Internal Medicine, EMMS, The Nazareth Hospital, Nazareth, Israel.
AD  - Faculty of Medicine in the Galilee, Bar-Ilan University, Safed, Israel.
FAU - Nasrallah, Najib
AU  - Nasrallah N
AD  - Division of Internal Medicine, EMMS, The Nazareth Hospital, Nazareth, Israel.
FAU - Mograbi, Julnar
AU  - Mograbi J
AD  - Intenal Medicine Department, Holy Family Hospital, Nazareth, Israel.
FAU - Mahamid, Mahmud
AU  - Mahamid M
AD  - Intenal Medicine Department, Holy Family Hospital, Nazareth, Israel.
AD  - Faculty of Medicine in the Galilee, Bar-Ilan University, Safed, Israel.
LA  - eng
PT  - Journal Article
DEP - 20150730
PL  - Australia
TA  - J Diabetes
JT  - Journal of diabetes
JID - 101504326
SB  - IM
MH  - Aged
MH  - Albuminuria/urine
MH  - Anemia/*complications/pathology
MH  - Cardiovascular Diseases/complications
MH  - Cause of Death
MH  - Diabetes Mellitus, Type 2/*complications/mortality
MH  - Female
MH  - Glomerular Filtration Rate
MH  - Hospitalization/*statistics & numerical data
MH  - Humans
MH  - Kaplan-Meier Estimate
MH  - Length of Stay/statistics & numerical data
MH  - Male
MH  - Middle Aged
MH  - Proportional Hazards Models
MH  - Renal Insufficiency, Chronic/*complications/pathology
MH  - Risk Factors
MH  - Severity of Illness Index
MH  - Survival Rate
MH  - Time Factors
OTO - NOTNLM
OT  - 1-year all-cause mortality
OT  - 1年全因死亡率
OT  - 1期与2期CKD
OT  - anemia
OT  - diabetes mellitus
OT  - length of hospitalization
OT  - stage 1 and 2 CKD
OT  - 住院时间
OT  - 糖尿病
OT  - 贫血
EDAT- 2015/06/05 06:00
MHDA- 2017/04/19 06:00
CRDT- 2015/06/05 06:00
PHST- 2015/03/24 00:00 [received]
PHST- 2015/05/08 00:00 [revised]
PHST- 2015/05/31 00:00 [accepted]
PHST- 2015/06/05 06:00 [entrez]
PHST- 2015/06/05 06:00 [pubmed]
PHST- 2017/04/19 06:00 [medline]
AID - 10.1111/1753-0407.12318 [doi]
PST - ppublish
SO  - J Diabetes. 2016 Jul;8(4):502-7. doi: 10.1111/1753-0407.12318. Epub 2015 Jul 30.