PMID- 26040764
OWN - NLM
STAT- MEDLINE
DCOM- 20160413
LR  - 20181113
IS  - 1423-0380 (Electronic)
IS  - 1010-4283 (Linking)
VI  - 36
IP  - 11
DP  - 2015 Nov
TI  - SOX 1, contrary to SOX 2, suppresses proliferation, migration, and invasion in 
      human laryngeal squamous cell carcinoma by inhibiting the Wnt/beta-catenin pathway.
PG  - 8625-35
LID - 10.1007/s13277-015-3389-z [doi]
AB  - Sex-determining region Y (SRY)-box protein 1 (SOX 1) has been reported to have 
      the inhibiting effects on various cancer cells; however, the expression and 
      effect of SOX 1 on laryngeal squamous cell carcinoma (LSCC) have not been 
      determined. Therefore, the aim of this study was to assess the anti-proliferation 
      and metastatic effects of SOX 1 and its related mechanisms on LSCC. According to 
      our present study, first, we found that overexpression of SOX 1 could 
      significantly inhibit proliferation and promote apoptosis in Tu212 cells. 
      Additionally, overexpression of SOX 1 suppressed the migration and invasion 
      potential of Tu212 cells via regulating Wnt/beta-catenin pathway. Finally, we 
      demonstrated for the first time that overexpression of SOX 1 could downregulate 
      the expression of SOX 2, and co-expression of SOX 1 and SOX 2 could reverse the 
      anti-tumor effect of SOX 1. In conclusion, our studies suggested that SOX 1 
      suppressed cell growth and invasion in Tu212 cells by inhibiting Wnt/beta-catenin 
      pathway, and the anti-tumor effect of SOX 1 could be weakened by SOX 2, which may 
      be a potential molecular basis for clinical treatment of LSCC.
FAU - Yang, Ning
AU  - Yang N
AD  - Department of Otorhinolaryngology, The First Affiliated Hospital of China Medical 
      University, 155 North Nanjing Street, Shenyang, 110001, People's Republic of 
      China. cmu1hyangning@163.com.
FAU - Wang, Yan
AU  - Wang Y
AD  - Department of Otorhinolaryngology, The First Affiliated Hospital of China Medical 
      University, 155 North Nanjing Street, Shenyang, 110001, People's Republic of 
      China.
FAU - Hui, Lian
AU  - Hui L
AD  - Department of Otorhinolaryngology, The First Affiliated Hospital of China Medical 
      University, 155 North Nanjing Street, Shenyang, 110001, People's Republic of 
      China.
FAU - Li, Xiaotian
AU  - Li X
AD  - Department of Otorhinolaryngology, The First Affiliated Hospital of China Medical 
      University, 155 North Nanjing Street, Shenyang, 110001, People's Republic of 
      China.
FAU - Jiang, Xuejun
AU  - Jiang X
AD  - Department of Otorhinolaryngology, The First Affiliated Hospital of China Medical 
      University, 155 North Nanjing Street, Shenyang, 110001, People's Republic of 
      China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150604
PL  - Netherlands
TA  - Tumour Biol
JT  - Tumour biology : the journal of the International Society for Oncodevelopmental 
      Biology and Medicine
JID - 8409922
RN  - 0 (SOXB1 Transcription Factors)
SB  - IM
MH  - Apoptosis
MH  - Carcinoma, Squamous Cell/*genetics/pathology
MH  - Cell Line, Tumor
MH  - Cell Movement/genetics
MH  - Cell Proliferation/genetics
MH  - Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - Laryngeal Neoplasms/*genetics/pathology
MH  - Neoplasm Invasiveness/genetics
MH  - Neoplasm Metastasis
MH  - SOXB1 Transcription Factors/*biosynthesis/genetics
MH  - Wnt Signaling Pathway
OTO - NOTNLM
OT  - Apoptosis
OT  - LSCC
OT  - Metastasis
OT  - SOX 1
OT  - SOX 2
OT  - Wnt/beta-catenin
EDAT- 2015/06/05 06:00
MHDA- 2016/04/14 06:00
CRDT- 2015/06/05 06:00
PHST- 2015/02/16 00:00 [received]
PHST- 2015/03/24 00:00 [accepted]
PHST- 2015/06/05 06:00 [entrez]
PHST- 2015/06/05 06:00 [pubmed]
PHST- 2016/04/14 06:00 [medline]
AID - 10.1007/s13277-015-3389-z [pii]
AID - 10.1007/s13277-015-3389-z [doi]
PST - ppublish
SO  - Tumour Biol. 2015 Nov;36(11):8625-35. doi: 10.1007/s13277-015-3389-z. Epub 2015 
      Jun 4.