PMID- 26040995
OWN - NLM
STAT- MEDLINE
DCOM- 20160509
LR  - 20181202
IS  - 1440-1843 (Electronic)
IS  - 1323-7799 (Linking)
VI  - 20
IP  - 7
DP  - 2015 Oct
TI  - Increases in peripheral SIRT1: a new biological characteristic of asthma.
PG  - 1066-72
LID - 10.1111/resp.12558 [doi]
AB  - BACKGROUND AND OBJECTIVE: Silent information regulator 1 (SIRT1) is a class III 
      histone deacetylase that exerts both anti-inflammatory and anti-aging effects. 
      However, no data are available regarding SIRT1 expression in patients with 
      asthma. Here, we studied SIRT1 levels in the serum of patients with asthma and 
      analysed the distribution of SIRT1 in both the serum and the lungs in an 
      asthmatic mouse model to determine its clinical significance. METHODS: Serum 
      SIRT1 levels, total immunoglobulin E (IgE) levels and peripheral blood eosinophil 
      percentages as well as pulmonary function were quantified in 97 patients with 
      asthma and 118 healthy volunteers. BALB/c mice were sensitized and challenged 
      using ovalbumin (OVA) to produce the asthmatic model, and SIRT1 levels in both 
      the serum and the lung tissues were subsequently measured. RESULTS: The serum 
      SIRT1 levels were significantly elevated in the patients with asthma compared 
      with the controls. Serum SIRT1 levels positively correlated with total IgE levels 
      and negatively correlated with pulmonary function. In the OVA-sensitized and 
      challenged mice, an increased serum SIRT1 level was confirmed, whereas decreased 
      SIRT1 expression was observed in the lung tissues. CONCLUSIONS: These data 
      indicate that lung SIRT1 expression decreased while serum SIRT1 increased in the 
      setting of asthma. Serum SIRT1 levels correlate positively with both IgE levels 
      and negatively with pulmonary function, suggesting that increased peripheral 
      SIRT1 levels represent a new biological characteristic of asthma. Increased serum 
      SIRT1 may be an auxiliary index for the diagnosis of asthma and elevating lung 
      SIRT1 levels may be a new strategy for asthma therapy.
CI  - (c) 2015 Asian Pacific Society of Respirology.
FAU - Wang, Yajun
AU  - Wang Y
AD  - Department of Respiratory Medicine, Affiliated Hospital of Guangdong Medical 
      College, Zhanjiang, Guangdong, China.
AD  - Clinical Research Center of Guangdong Medical College, Zhanjiang, Guangdong, 
      China.
FAU - Li, Dongming
AU  - Li D
AD  - Department of Respiratory Medicine, Affiliated Hospital of Guangdong Medical 
      College, Zhanjiang, Guangdong, China.
FAU - Ma, Guoda
AU  - Ma G
AD  - Clinical Research Center of Guangdong Medical College, Zhanjiang, Guangdong, 
      China.
FAU - Li, Wen
AU  - Li W
AD  - Department of Respiratory Medicine, Affiliated Hospital of Guangdong Medical 
      College, Zhanjiang, Guangdong, China.
FAU - Wu, Jun
AU  - Wu J
AD  - Department of Respiratory Medicine, Affiliated Hospital of Guangdong Medical 
      College, Zhanjiang, Guangdong, China.
FAU - Lai, Tianwen
AU  - Lai T
AD  - Department of Respiratory Medicine, Affiliated Hospital of Guangdong Medical 
      College, Zhanjiang, Guangdong, China.
FAU - Huang, Dan
AU  - Huang D
AD  - Department of Respiratory Medicine, Affiliated Hospital of Guangdong Medical 
      College, Zhanjiang, Guangdong, China.
FAU - Zhao, Xuanna
AU  - Zhao X
AD  - Department of Respiratory Medicine, Affiliated Hospital of Guangdong Medical 
      College, Zhanjiang, Guangdong, China.
FAU - Lv, Quanchao
AU  - Lv Q
AD  - Department of Respiratory Medicine, Affiliated Hospital of Guangdong Medical 
      College, Zhanjiang, Guangdong, China.
FAU - Chen, Min
AU  - Chen M
AD  - Department of Respiratory Medicine, Affiliated Hospital of Guangdong Medical 
      College, Zhanjiang, Guangdong, China.
FAU - Wu, Bin
AU  - Wu B
AD  - Department of Respiratory Medicine, Affiliated Hospital of Guangdong Medical 
      College, Zhanjiang, Guangdong, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150603
PL  - Australia
TA  - Respirology
JT  - Respirology (Carlton, Vic.)
JID - 9616368
RN  - 0 (Biomarkers)
RN  - 0 (Serine Proteinase Inhibitors)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 9006-59-1 (Ovalbumin)
RN  - EC 3.5.1.- (SIRT1 protein, human)
RN  - EC 3.5.1.- (Sirtuin 1)
SB  - IM
MH  - Adult
MH  - Aging/*blood
MH  - Animals
MH  - *Asthma/blood/diagnosis/physiopathology
MH  - Biomarkers/blood/metabolism
MH  - Disease Models, Animal
MH  - *Eosinophils
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/*blood
MH  - Inflammation/*blood
MH  - Leukocyte Count
MH  - Lung/metabolism/physiopathology
MH  - Male
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Ovalbumin/pharmacology
MH  - Respiratory Function Tests
MH  - Serine Proteinase Inhibitors/pharmacology
MH  - *Sirtuin 1/blood/metabolism
MH  - Statistics as Topic
OTO - NOTNLM
OT  - aging
OT  - asthma
OT  - immunoglobulin E
OT  - serum
OT  - silent information regulator 1
EDAT- 2015/06/05 06:00
MHDA- 2016/05/10 06:00
CRDT- 2015/06/05 06:00
PHST- 2014/12/17 00:00 [received]
PHST- 2015/03/26 00:00 [revised]
PHST- 2015/03/27 00:00 [revised]
PHST- 2015/04/12 00:00 [accepted]
PHST- 2015/06/05 06:00 [entrez]
PHST- 2015/06/05 06:00 [pubmed]
PHST- 2016/05/10 06:00 [medline]
AID - 10.1111/resp.12558 [doi]
PST - ppublish
SO  - Respirology. 2015 Oct;20(7):1066-72. doi: 10.1111/resp.12558. Epub 2015 Jun 3.