PMID- 26042269
OWN - NLM
STAT- MEDLINE
DCOM- 20150619
LR  - 20220317
IS  - 0256-9574 (Print)
VI  - 104
IP  - 12
DP  - 2014 Dec
TI  - Retinoblastoma outcome at a single institution in South Africa.
PG  - 859-63
AB  - INTRODUCTION: Retinoblastoma (RB) is the most common eye cancer in children. 
      Early detection is necessary for cure. OBJECTIVE: To compare stage and outcome of 
      children with RB treated at Kalafong Hospital, Pretoria, South Africa (SA), 
      during two time periods (1993 - 2000 and 2001 - 2008, after outreach 
      interventions in 2000 and introduction of compulsory community service for 
      doctors in 1998). METHODS: Data collected included demography (age, gender, date 
      of birth), stage and treatment received. The main outcome measure was 
      disease-free survival and the study end-point was 60 months after diagnosis. 
      RESULTS: There were 51 patients during the time period 1993 - 2000 (group 1) and 
      73 during 2001 - 2008 (group 2), with median ages of 32 and 26 months, 
      respectively (marginally significantly younger in group 2; p = 0.046). In group 
      1, the majority (57%) presented with advanced disease (stages III and IV), with a 
      decline in this proportion in group 2 (40%) indicating a downward but not 
      significant trend (p = 0.075). Bilateral disease was diagnosed in 22% of patients 
      in group 1 and 33% in group 2. Overall survival was 33% and 43% for groups 1 and 
      2, respectively. Excluding absconding patients, event-free survival was 50% in 
      group 1, improving to 68% in group 2 (not statistically significant; p = 0.18). 
      Fewer patients needed radiotherapy during the second period (statistically 
      significant; p = 0.04), probably because of less advanced disease. CONCLUSION: 
      Poor outcome is probably a result of late diagnosis. It is important to implement 
      a strategy that will ensure early diagnosis and optimal management of RB in SA.
FAU - Kruger, M
AU  - Kruger M
FAU - Reynders, D
AU  - Reynders D
FAU - Omar, F
AU  - Omar F
FAU - Schoeman, J
AU  - Schoeman J
FAU - Wedi, O
AU  - Wedi O
FAU - Harvey, J
AU  - Harvey J
LA  - eng
PT  - Journal Article
PL  - South Africa
TA  - S Afr Med J
JT  - South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde
JID - 0404520
SB  - IM
CIN - S Afr Med J. 2014 Dec;104(12):856. PMID: 26042267
MH  - Child
MH  - Child, Preschool
MH  - Disease-Free Survival
MH  - Early Detection of Cancer
MH  - Female
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Male
MH  - Neoplasm Staging
MH  - *Outcome and Process Assessment, Health Care
MH  - Prospective Studies
MH  - Retinoblastoma/diagnosis/*epidemiology/pathology
MH  - South Africa/epidemiology
MH  - Survival Rate
EDAT- 2015/06/05 06:00
MHDA- 2015/06/20 06:00
CRDT- 2015/06/05 06:00
PHST- 2015/06/05 06:00 [entrez]
PHST- 2015/06/05 06:00 [pubmed]
PHST- 2015/06/20 06:00 [medline]
AID - 10.7196/samj.8255 [doi]
PST - ppublish
SO  - S Afr Med J. 2014 Dec;104(12):859-63. doi: 10.7196/samj.8255.