PMID- 26042718
OWN - NLM
STAT- MEDLINE
DCOM- 20160307
LR  - 20220330
IS  - 1873-0191 (Electronic)
IS  - 0928-4931 (Linking)
VI  - 53
DP  - 2015 Aug
TI  - Green synthesis, characterization of gold and silver nanoparticles and their 
      potential application for cancer therapeutics.
PG  - 298-309
LID - S0928-4931(15)30049-7 [pii]
LID - 10.1016/j.msec.2015.04.048 [doi]
AB  - In the present article, we demonstrate the delivery of anti-cancer drug to the 
      cancer cells using biosynthesized gold and silver nanoparticles (b-AuNP & 
      b-AgNP). The nanoparticles synthesized by using Butea monosperma (BM) leaf 
      extract are thoroughly characterized by various analytical techniques. Both 
      b-AuNP and b-AgNP are stable in biological buffers and biocompatible towards 
      normal endothelial cells (HUVEC, ECV-304) as well as cancer cell lines (B16F10, 
      MCF-7, HNGC2 & A549). Administration of nanoparticle based drug delivery systems 
      (DDSs) using doxorubicin (DOX) [b-Au-500-DOX and b-Ag-750-DOX] shows significant 
      inhibition of cancer cell proliferation (B16F10, MCF-7) compared to pristine 
      drug. Therefore, we strongly believe that biosynthesized nanoparticles will be 
      useful for the development of cancer therapy using nanomedicine approach in near 
      future.
CI  - Copyright (c) 2015 Elsevier B.V. All rights reserved.
FAU - Patra, Sujata
AU  - Patra S
AD  - Biomaterials Group, CSIR-Indian Institute of Chemical Technology, Uppal Road, 
      Tarnaka, Hyderabad 500007, Telangana State, India.
FAU - Mukherjee, Sudip
AU  - Mukherjee S
AD  - Biomaterials Group, CSIR-Indian Institute of Chemical Technology, Uppal Road, 
      Tarnaka, Hyderabad 500007, Telangana State, India.
FAU - Barui, Ayan Kumar
AU  - Barui AK
AD  - Biomaterials Group, CSIR-Indian Institute of Chemical Technology, Uppal Road, 
      Tarnaka, Hyderabad 500007, Telangana State, India.
FAU - Ganguly, Anirban
AU  - Ganguly A
AD  - Biomaterials Group, CSIR-Indian Institute of Chemical Technology, Uppal Road, 
      Tarnaka, Hyderabad 500007, Telangana State, India.
FAU - Sreedhar, Bojja
AU  - Sreedhar B
AD  - Inorganic and Physical Chemistry Division, CSIR-Indian Institute of Chemical 
      Technology, Uppal Road, Tarnaka, Hyderabad 500007, Telangana State, India.
FAU - Patra, Chitta Ranjan
AU  - Patra CR
AD  - Biomaterials Group, CSIR-Indian Institute of Chemical Technology, Uppal Road, 
      Tarnaka, Hyderabad 500007, Telangana State, India. Electronic address: 
      crpatra@iict.res.in.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150501
PL  - Netherlands
TA  - Mater Sci Eng C Mater Biol Appl
JT  - Materials science & engineering. C, Materials for biological applications
JID - 101484109
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Plant Extracts)
RN  - 3M4G523W1G (Silver)
RN  - 7440-57-5 (Gold)
RN  - 80168379AG (Doxorubicin)
SB  - IM
MH  - Animals
MH  - Antineoplastic Agents/*chemistry/pharmacokinetics/pharmacology
MH  - Butea
MH  - Cell Line, Tumor
MH  - Cell Proliferation/drug effects
MH  - Cell Survival/drug effects
MH  - Doxorubicin/chemistry/pharmacokinetics/pharmacology
MH  - *Drug Delivery Systems
MH  - Gold/*chemistry/pharmacokinetics
MH  - Green Chemistry Technology
MH  - Humans
MH  - Metal Nanoparticles/*chemistry
MH  - Mice
MH  - Plant Extracts/metabolism
MH  - Silver/*chemistry/pharmacokinetics
OTO - NOTNLM
OT  - Biocompatible
OT  - Butea monosperma
OT  - Cancer therapy
OT  - Drug delivery systems
OT  - Gold and silver nanoparticles
OT  - Green synthesis
EDAT- 2015/06/05 06:00
MHDA- 2016/03/08 06:00
CRDT- 2015/06/05 06:00
PHST- 2014/11/30 00:00 [received]
PHST- 2015/03/17 00:00 [revised]
PHST- 2015/04/29 00:00 [accepted]
PHST- 2015/06/05 06:00 [entrez]
PHST- 2015/06/05 06:00 [pubmed]
PHST- 2016/03/08 06:00 [medline]
AID - S0928-4931(15)30049-7 [pii]
AID - 10.1016/j.msec.2015.04.048 [doi]
PST - ppublish
SO  - Mater Sci Eng C Mater Biol Appl. 2015 Aug;53:298-309. doi: 
      10.1016/j.msec.2015.04.048. Epub 2015 May 1.