PMID- 26042767
OWN - NLM
STAT- MEDLINE
DCOM- 20160405
LR  - 20161125
IS  - 1878-0180 (Electronic)
IS  - 1878-0180 (Linking)
VI  - 49
DP  - 2015 Sep
TI  - Biomaterial characteristics and application of silicone rubber and PVA hydrogels 
      mimicked in organ groups for prostate brachytherapy.
PG  - 220-34
LID - S1751-6161(15)00179-4 [pii]
LID - 10.1016/j.jmbbm.2015.05.012 [doi]
AB  - It is definite that transparent material with similar structural characteristics 
      and mechanical properties to human tissue is favorable for experimental study of 
      prostate brachytherapy. In this paper, a kind of transparent polyvinyl alcohol 
      (PVA) hydrogel and silicone rubber are developed as suitable substitutions for 
      human soft tissue. Segmentation and 3D reconstruction of medical image are 
      performed to manufacture the mould of organ groups through rapid prototyping 
      technology. Micro-structure observation, force test and CCD deformation test have 
      been conducted to investigate the structure and mechanical properties of PVA 
      hydrogel used in organ group mockup. Scanning electron microscope (SEM) image 
      comparison results show that PVA hydrogel consisting of 3 g PVA, 17 g de-ionized 
      water, 80 g dimethyl-sulfoxide (DMSO), 4 g NaCl, 1.5 g NaOH, 3 g epichlorohydrin 
      (ECH) and 7 freeze/thaw cycles reveals similar micro-structure to human prostate 
      tissue. Through the insertion force comparison between organ group mockup and 
      clinical prostate brachytherapy, PVA hydrogel and silicone rubber are found to 
      have the same mechanical properties as prostate tissue and muscle. CCD 
      deformation test results show that insertion force suffers a sharp decrease and a 
      relaxation of tissue deformation appears when needle punctures the capsule of 
      prostate model. The results exhibit that organ group mockup consisting of PVA 
      hydrogel, silicone rubber, membrane and agarose satisfies the needs of prostate 
      brachytherapy simulation in general and can be used to mimic the soft tissues in 
      pelvic structure.
CI  - Copyright (c) 2015 Elsevier Ltd. All rights reserved.
FAU - Li, Pan
AU  - Li P
AD  - Centre for Advanced Mechanisms and Robotics, School of Mechanical Engineering, 
      Tianjin University, Tianjin 300072, China.
FAU - Jiang, Shan
AU  - Jiang S
AD  - Centre for Advanced Mechanisms and Robotics, School of Mechanical Engineering, 
      Tianjin University, Tianjin 300072, China. Electronic address: 
      shanjmri@tju.edu.cn.
FAU - Yu, Yan
AU  - Yu Y
AD  - Division of Medical Physics, Department of Radiation Oncology, Thomas Jefferson 
      University, Kimmel Cancer Center, 111 South 11th Street, Philadelphia, PA 19107, 
      USA.
FAU - Yang, Jun
AU  - Yang J
AD  - Department of Imaging, Tianjin Union Medicine Center, Tianjin 300121, China.
FAU - Yang, Zhiyong
AU  - Yang Z
AD  - Centre for Advanced Mechanisms and Robotics, School of Mechanical Engineering, 
      Tianjin University, Tianjin 300072, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150521
PL  - Netherlands
TA  - J Mech Behav Biomed Mater
JT  - Journal of the mechanical behavior of biomedical materials
JID - 101322406
RN  - 0 (Silicone Elastomers)
RN  - 0 (polyvinyl alcohol hydrogel)
RN  - 9002-89-5 (Polyvinyl Alcohol)
SB  - IM
MH  - *Biomimetic Materials
MH  - Brachytherapy/*instrumentation
MH  - Humans
MH  - Imaging, Three-Dimensional
MH  - Male
MH  - *Materials Testing
MH  - *Mechanical Phenomena
MH  - Needles
MH  - Pelvis
MH  - *Polyvinyl Alcohol
MH  - *Prostate/cytology
MH  - *Silicone Elastomers
OTO - NOTNLM
OT  - Mechanical properties
OT  - Micro-structure
OT  - Organ group mockup
OT  - Polyvinyl alcohol hydrogel
OT  - Prostate brachytherapy
OT  - Silicone rubber
EDAT- 2015/06/05 06:00
MHDA- 2016/04/06 06:00
CRDT- 2015/06/05 06:00
PHST- 2015/02/23 00:00 [received]
PHST- 2015/05/01 00:00 [revised]
PHST- 2015/05/13 00:00 [accepted]
PHST- 2015/06/05 06:00 [entrez]
PHST- 2015/06/05 06:00 [pubmed]
PHST- 2016/04/06 06:00 [medline]
AID - S1751-6161(15)00179-4 [pii]
AID - 10.1016/j.jmbbm.2015.05.012 [doi]
PST - ppublish
SO  - J Mech Behav Biomed Mater. 2015 Sep;49:220-34. doi: 10.1016/j.jmbbm.2015.05.012. 
      Epub 2015 May 21.