PMID- 26045825
OWN - NLM
STAT- MEDLINE
DCOM- 20160329
LR  - 20181113
IS  - 1936-2625 (Electronic)
IS  - 1936-2625 (Linking)
VI  - 8
IP  - 3
DP  - 2015
TI  - Osteoinductive factor is a novel biomarker for the diagnosis of early diabetic 
      nephropathy.
PG  - 3110-5
AB  - BACKGROUND: Microalbuminuria is the earliest clinical sign of diabetic 
      nephropathy (DN). However, earlier markers as a diagnostic tool for DN was 
      required for the invalid of microalbuminuria in some cases. Osteoinductive factor 
      (OIF) was known to be an essential component of the normal vascular matrix. We 
      aimed to research the relationship between DN and OIF, and discussed the 
      availability of the serological markers for earlier stage of DN. METHOD: One 
      hundred twenty Chinese subjects, who included patients with type 2 diabetes 
      mellitus (T2DM), DN with microalbuminuria, and DN with macroalbuminuria, as well 
      as healthy controls, were enrolled in this study. Serum OIF levels were examined 
      by ELISA and other clinical biochemical parameters were tested based on standard 
      methods. RESULTS: Our results indicated that, serum OIF levels were significantly 
      increased in DN subjects compared with healthy and T2DM subjects (P<0.05 
      respectively). However, no significant changes in serum OIF levels were found 
      between T2DM and healthy subjects. Furthermore, serum OIF had negative 
      correlation with estimated glomerular filtration rate (eGFR) and positive 
      correlation with blood urea nitrogen(BUN) and creatinine. ROC curve analysis 
      showed that serum OIF level was a good sensitive and specificity marker for 
      microalbuminuria and early renal damage with sensitivity of 86.7% and specificity 
      of 95%, as well as for macroalbuminuria and damage progress with sensitivity of 
      90% and specificity of 95%. CONCLUSION: OIF may be an indicator of the 
      earlier-stage DN in subjects with T2DM. Understanding the exact mechanism of 
      up-regulated OIF in subjects with DN requires further study.
FAU - Wang, Suijun
AU  - Wang S
AD  - Department of Endocrinology and Metabolism, Henan Provincial People's Hospital, 
      Zhengzhou University Zhengzhou 450003, Henan, People's Republic of China.
FAU - Wang, Yanfang
AU  - Wang Y
AD  - Department of Endocrinology and Metabolism, Henan Provincial People's Hospital, 
      Zhengzhou University Zhengzhou 450003, Henan, People's Republic of China.
FAU - Zheng, Ruizhi
AU  - Zheng R
AD  - Department of Endocrinology and Metabolism, Henan Provincial People's Hospital, 
      Zhengzhou University Zhengzhou 450003, Henan, People's Republic of China.
FAU - Zhao, Zhigang
AU  - Zhao Z
AD  - Department of Endocrinology and Metabolism, Henan Provincial People's Hospital, 
      Zhengzhou University Zhengzhou 450003, Henan, People's Republic of China.
FAU - Ma, Yuehua
AU  - Ma Y
AD  - Department of Endocrinology and Metabolism, Henan Provincial People's Hospital, 
      Zhengzhou University Zhengzhou 450003, Henan, People's Republic of China.
LA  - eng
PT  - Journal Article
DEP - 20150301
PL  - United States
TA  - Int J Clin Exp Pathol
JT  - International journal of clinical and experimental pathology
JID - 101480565
RN  - 0 (Biomarkers)
RN  - 0 (Intercellular Signaling Peptides and Proteins)
RN  - 0 (OGN protein, human)
SB  - IM
MH  - Adult
MH  - Area Under Curve
MH  - Biomarkers/*blood
MH  - Diabetes Mellitus, Type 2/*blood
MH  - Diabetic Nephropathies/*blood
MH  - Early Diagnosis
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Humans
MH  - Intercellular Signaling Peptides and Proteins/*blood
MH  - Male
MH  - Middle Aged
MH  - ROC Curve
MH  - Sensitivity and Specificity
PMC - PMC4440134
OTO - NOTNLM
OT  - Diabetic nephropathy
OT  - biomarker
OT  - early diagnosis
OT  - osteoinductive factor
EDAT- 2015/06/06 06:00
MHDA- 2016/03/30 06:00
PMCR- 2015/03/01
CRDT- 2015/06/06 06:00
PHST- 2014/12/15 00:00 [received]
PHST- 2015/01/05 00:00 [accepted]
PHST- 2015/06/06 06:00 [entrez]
PHST- 2015/06/06 06:00 [pubmed]
PHST- 2016/03/30 06:00 [medline]
PHST- 2015/03/01 00:00 [pmc-release]
PST - epublish
SO  - Int J Clin Exp Pathol. 2015 Mar 1;8(3):3110-5. eCollection 2015.