PMID- 26045870 OWN - NLM STAT- MEDLINE DCOM- 20160308 LR - 20181113 IS - 1936-2625 (Electronic) IS - 1936-2625 (Linking) VI - 8 IP - 3 DP - 2015 TI - Mantle cell lymphoma concurrent with T-large granular lymphocytic leukemia: report of a case and review of literature. PG - 3365-9 AB - Mantle cell lymphoma is one of the B-cell lymphomas. The concurrent presentation of mantle cell lymphoma with large granular lymphocytic leukemia simultaneously has never been reported. In this case we present an old man with concomitant mantle cell lymphoma and large granular lymphocytic leukemia diagnosed by the morphology of the bone marrow aspiration, immunophenotyping of the peripheral blood by flow cytometry detecting the increased CD3+CD4-CD8+ cells, immunohistochemical studies of lymph node showed cyclinD1+, chromosome analysis by fluorescence in situ hybridization (FISH) showed t(11,14), positive results of IGH and TCR rearrangement studies. The patient discharged from the hospital voluntarily and lost the follow-up. A brief discussion is also presented. FAU - Xiao, Zhengrui AU - Xiao Z AD - Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital Nanjing 210029, China. FAU - Ni, Ying AU - Ni Y AD - Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital Nanjing 210029, China. FAU - Yin, Guangli AU - Yin G AD - Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital Nanjing 210029, China. FAU - Wu, Hanxin AU - Wu H AD - Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital Nanjing 210029, China. FAU - Li, Jianyong AU - Li J AD - Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital Nanjing 210029, China. FAU - Miao, Kourong AU - Miao K AD - Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital Nanjing 210029, China. LA - eng PT - Case Reports PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Review DEP - 20150301 PL - United States TA - Int J Clin Exp Pathol JT - International journal of clinical and experimental pathology JID - 101480565 RN - 0 (Biomarkers, Tumor) SB - IM MH - Aged MH - Biomarkers, Tumor/analysis/genetics MH - Bone Marrow Examination MH - Chromosomes, Human, Pair 11 MH - Chromosomes, Human, Pair 14 MH - Flow Cytometry MH - Gene Rearrangement MH - Gene Rearrangement, T-Lymphocyte MH - Genes, Immunoglobulin Heavy Chain MH - Genetic Predisposition to Disease MH - Humans MH - Immunohistochemistry MH - Immunophenotyping MH - In Situ Hybridization, Fluorescence MH - Leukemia, Large Granular Lymphocytic/genetics/immunology/*pathology MH - Lymphoma, Mantle-Cell/genetics/immunology/*pathology MH - Male MH - Neoplasms, Multiple Primary/genetics/immunology/*pathology MH - Phenotype MH - Translocation, Genetic PMC - PMC4440179 OTO - NOTNLM OT - Mantle cell lymphoma OT - concurrent OT - large granular lymphocytic leukemia EDAT- 2015/06/06 06:00 MHDA- 2016/03/10 06:00 PMCR- 2015/03/01 CRDT- 2015/06/06 06:00 PHST- 2014/12/28 00:00 [received] PHST- 2015/02/23 00:00 [accepted] PHST- 2015/06/06 06:00 [entrez] PHST- 2015/06/06 06:00 [pubmed] PHST- 2016/03/10 06:00 [medline] PHST- 2015/03/01 00:00 [pmc-release] PST - epublish SO - Int J Clin Exp Pathol. 2015 Mar 1;8(3):3365-9. eCollection 2015.