PMID- 26047771 OWN - NLM STAT- MEDLINE DCOM- 20160412 LR - 20220330 IS - 1875-8312 (Electronic) IS - 1569-5794 (Print) IS - 1569-5794 (Linking) VI - 31 IP - 6 DP - 2015 Aug TI - Assessment of the relationships between myocardial contractility and infarct tissue revealed by serial magnetic resonance imaging in patients with acute myocardial infarction. PG - 1201-9 LID - 10.1007/s10554-015-0678-y [doi] AB - Imaging changes in left ventricular (LV) volumes during the cardiac cycle and LV ejection fraction do not provide information on regional contractility. Displacement ENcoding with Stimulated Echoes (DENSE) is a strain-encoded cardiac magnetic resonance (CMR) technique that measures strain directly. We investigated the relationships between strain revealed by DENSE and the presence and extent of infarction in patients with recent myocardial infarction (MI). 50 male subjects were invited to undergo serial CMR within 7 days of MI (baseline) and after 6 months (follow-up; n = 47). DENSE and late gadolinium enhancement (LGE) images were acquired to enable localised regional quantification of peak circumferential strain (Ecc) and the extent of infarction, respectively. We assessed: (1) receiver operating characteristic (ROC) analysis for the classification of LGE, (2) strain differences according to LGE status (remote, adjacent, infarcted) and (3) changes in strain revealed between baseline and follow-up. 300 and 258 myocardial segments were available for analysis at baseline and follow-up respectively. LGE was present in 130/300 (43%) and 97/258 (38%) segments, respectively. ROC analysis revealed moderately high values for peak Ecc at baseline [threshold 12.8%; area-under-curve (AUC) 0.88, sensitivity 84%, specificity 78%] and at follow-up (threshold 15.8%; AUC 0.76, sensitivity 85%, specificity 64%). Differences were observed between remote, adjacent and infarcted segments. Between baseline and follow-up, increases in peak Ecc were observed in infarcted segments (median difference of 5.6%) and in adjacent segments (1.5%). Peak Ecc at baseline was indicative of the change in LGE status between baseline and follow-up. Strain-encoded CMR with DENSE has the potential to provide clinically useful information on contractility and its recovery over time in patients with MI. FAU - McComb, Christie AU - McComb C AD - Clinical Physics, NHS Greater Glasgow and Clyde, Glasgow, UK. FAU - Carrick, David AU - Carrick D FAU - McClure, John D AU - McClure JD FAU - Woodward, Rosemary AU - Woodward R FAU - Radjenovic, Aleksandra AU - Radjenovic A FAU - Foster, John E AU - Foster JE FAU - Berry, Colin AU - Berry C LA - eng GR - MR/N003403/1/MRC_/Medical Research Council/United Kingdom GR - PG/14/64/31043/BHF_/British Heart Foundation/United Kingdom GR - SCD/01/CSO_/Chief Scientist Office/United Kingdom GR - PG/11/2/28474/BHF_/British Heart Foundation/United Kingdom PT - Comparative Study PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20150606 PL - United States TA - Int J Cardiovasc Imaging JT - The international journal of cardiovascular imaging JID - 100969716 RN - 0 (Contrast Media) RN - 0 (Organometallic Compounds) RN - 6HG8UB2MUY (Meglumine) RN - L0ND3981AG (gadoterate meglumine) SB - IM MH - Adult MH - Aged MH - Aged, 80 and over MH - Area Under Curve MH - Contrast Media MH - Humans MH - *Magnetic Resonance Imaging, Cine MH - Male MH - Meglumine MH - Middle Aged MH - *Myocardial Contraction MH - Myocardial Infarction/*diagnosis/pathology/physiopathology/therapy MH - Myocardium/*pathology MH - Organometallic Compounds MH - Percutaneous Coronary Intervention MH - Predictive Value of Tests MH - ROC Curve MH - Recovery of Function MH - Stress, Mechanical MH - Stroke Volume MH - Time Factors MH - Treatment Outcome MH - *Ventricular Function, Left PMC - PMC4486782 EDAT- 2015/06/07 06:00 MHDA- 2016/04/14 06:00 PMCR- 2015/06/06 CRDT- 2015/06/07 06:00 PHST- 2014/12/25 00:00 [received] PHST- 2015/05/11 00:00 [accepted] PHST- 2015/06/07 06:00 [entrez] PHST- 2015/06/07 06:00 [pubmed] PHST- 2016/04/14 06:00 [medline] PHST- 2015/06/06 00:00 [pmc-release] AID - 678 [pii] AID - 10.1007/s10554-015-0678-y [doi] PST - ppublish SO - Int J Cardiovasc Imaging. 2015 Aug;31(6):1201-9. doi: 10.1007/s10554-015-0678-y. Epub 2015 Jun 6.