PMID- 26047824
OWN - NLM
STAT- MEDLINE
DCOM- 20160216
LR  - 20181202
IS  - 1872-7727 (Electronic)
IS  - 0720-048X (Linking)
VI  - 84
IP  - 8
DP  - 2015 Aug
TI  - Quantitative circumferential strain analysis using adenosine 
      triphosphate-stress/rest 3-T tagged magnetic resonance to evaluate regional 
      contractile dysfunction in ischemic heart disease.
PG  - 1493-1501
LID - S0720-048X(15)00225-9 [pii]
LID - 10.1016/j.ejrad.2015.04.025 [doi]
AB  - PURPOSE: We evaluated whether a quantitative circumferential strain (CS) analysis 
      using adenosine triphosphate (ATP)-stress/rest 3-T tagged magnetic resonance (MR) 
      imaging can depict myocardial ischemia as contractile dysfunction during stress 
      in patients with suspected coronary artery disease (CAD). We evaluated whether it 
      can differentiate between non-ischemia, myocardial ischemia, and infarction. We 
      assessed its diagnostic performance in comparison with ATP-stress myocardial 
      perfusion MR and late gadolinium enhancement (LGE)-MR imaging. METHODS: In 38 
      patients suspected of having CAD, myocardial segments were categorized as 
      non-ischemic (n=485), ischemic (n=74), or infarcted (n=49) from the results of 
      perfusion MR and LGE-MR. The peak negative CS value, peak circumferential 
      systolic strain rate (CSR), and time-to-peak CS were measured in 16 segments. 
      RESULTS: A cutoff value of -12.0% for CS at rest allowed differentiation between 
      infarcted and other segments with a sensitivity of 79%, specificity of 76%, 
      accuracy of 76%, and an area under the curve (AUC) of 0.81. Additionally, a 
      cutoff value of 477.3ms for time-to-peak CS at rest allowed differentiation 
      between infarcted and other segments with a sensitivity of 61%, specificity of 
      91%, accuracy of 88%, and an AUC of 0.75. The differences in CS values between 
      ATP-stress and rest conditions (DeltaCS) in non-ischemic segments (median [first 
      quartile, third quartile] -1.7 [-3.2, -0.1] %) were smaller than in segments with 
      ischemia (+1.1 [+0.3, +2.3] %, p<0.001). A cutoff value of +0.3% for the DeltaCS 
      value could differentiate segments with ischemia from non-ischemic segments with 
      a sensitivity of 75%, a specificity of 82%, an accuracy of 82%, and an AUC of 
      0.86. CONCLUSIONS: Circumferential strain analysis using tagged MR can 
      quantitatively assess contractile dysfunction in ischemic and infarcted 
      myocardium.
CI  - Copyright (c) 2015 Elsevier Ireland Ltd. All rights reserved.
FAU - Nakamura, Masashi
AU  - Nakamura M
AD  - Department of Radiology, Ehime University Graduate School of Medicine, 
      Shitsukawa, Toon-city, Ehime 791-0295, Japan. Electronic address: 
      m.nakamura1230@gmail.com.
FAU - Kido, Tomoyuki
AU  - Kido T
AD  - Department of Radiology, Saiseikai Matsuyama Hospital, Ehime 791-0295, Japan.
FAU - Kido, Teruhito
AU  - Kido T
AD  - Department of Radiology, Ehime University Graduate School of Medicine, 
      Shitsukawa, Toon-city, Ehime 791-0295, Japan.
FAU - Tanabe, Yuki
AU  - Tanabe Y
AD  - Department of Radiology, Ehime University Graduate School of Medicine, 
      Shitsukawa, Toon-city, Ehime 791-0295, Japan.
FAU - Matsuda, Takuya
AU  - Matsuda T
AD  - Department of Radiology, Ehime University Graduate School of Medicine, 
      Shitsukawa, Toon-city, Ehime 791-0295, Japan.
FAU - Nishiyama, Yoshiko
AU  - Nishiyama Y
AD  - Department of Radiology, Ehime University Graduate School of Medicine, 
      Shitsukawa, Toon-city, Ehime 791-0295, Japan.
FAU - Miyagawa, Masao
AU  - Miyagawa M
AD  - Department of Radiology, Ehime University Graduate School of Medicine, 
      Shitsukawa, Toon-city, Ehime 791-0295, Japan.
FAU - Mochizuki, Teruhito
AU  - Mochizuki T
AD  - Department of Radiology, Ehime University Graduate School of Medicine, 
      Shitsukawa, Toon-city, Ehime 791-0295, Japan.
LA  - eng
PT  - Journal Article
DEP - 20150511
PL  - Ireland
TA  - Eur J Radiol
JT  - European journal of radiology
JID - 8106411
RN  - 0 (Contrast Media)
RN  - 8L70Q75FXE (Adenosine Triphosphate)
RN  - K2I13DR72L (Gadolinium DTPA)
SB  - IM
MH  - *Adenosine Triphosphate
MH  - Aged
MH  - Area Under Curve
MH  - Contrast Media
MH  - Female
MH  - Gadolinium DTPA
MH  - Heart/physiopathology
MH  - Humans
MH  - Image Enhancement
MH  - *Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Myocardial Ischemia/*diagnosis/*physiopathology
MH  - Reproducibility of Results
MH  - Rest
MH  - Sensitivity and Specificity
MH  - Severity of Illness Index
OTO - NOTNLM
OT  - Circumferential strain
OT  - Magnetic resonance imaging
OT  - Myocardial infarction
OT  - Myocardial ischemia
OT  - Tagged MR
EDAT- 2015/06/07 06:00
MHDA- 2016/02/18 06:00
CRDT- 2015/06/07 06:00
PHST- 2014/11/24 00:00 [received]
PHST- 2015/04/11 00:00 [revised]
PHST- 2015/04/22 00:00 [accepted]
PHST- 2015/06/07 06:00 [entrez]
PHST- 2015/06/07 06:00 [pubmed]
PHST- 2016/02/18 06:00 [medline]
AID - S0720-048X(15)00225-9 [pii]
AID - 10.1016/j.ejrad.2015.04.025 [doi]
PST - ppublish
SO  - Eur J Radiol. 2015 Aug;84(8):1493-1501. doi: 10.1016/j.ejrad.2015.04.025. Epub 
      2015 May 11.