PMID- 26048614
OWN - NLM
STAT- MEDLINE
DCOM- 20160425
LR  - 20170728
IS  - 1090-2430 (Electronic)
IS  - 0014-4886 (Linking)
VI  - 275 Pt 3
DP  - 2016 Jan
TI  - Cerebral Vascular Injury in Traumatic Brain Injury.
PG  - 353-366
LID - S0014-4886(15)30006-6 [pii]
LID - 10.1016/j.expneurol.2015.05.019 [doi]
AB  - Traumatic cerebral vascular injury (TCVI) is a very frequent, if not universal, 
      feature after traumatic brain injury (TBI). It is likely responsible, at least in 
      part, for functional deficits and TBI-related chronic disability. Because there 
      are multiple pharmacologic and non-pharmacologic therapies that promote vascular 
      health, TCVI is an attractive target for therapeutic intervention after TBI. The 
      cerebral microvasculature is a component of the neurovascular unit (NVU) coupling 
      neuronal metabolism with local cerebral blood flow. The NVU participates in the 
      pathogenesis of TBI, either directly from physical trauma or as part of the 
      cascade of secondary injury that occurs after TBI. Pathologically, there is 
      extensive cerebral microvascular injury in humans and experimental animal, 
      identified with either conventional light microscopy or ultrastructural 
      examination. It is seen in acute and chronic TBI, and even described in chronic 
      traumatic encephalopathy (CTE). Non-invasive, physiologic measures of cerebral 
      microvascular function show dysfunction after TBI in humans and experimental 
      animal models of TBI. These include imaging sequences (MRI-ASL), Transcranial 
      Doppler (TCD), and Near InfraRed Spectroscopy (NIRS). Understanding the 
      pathophysiology of TCVI, a relatively under-studied component of TBI, has promise 
      for the development of novel therapies for TBI.
CI  - Published by Elsevier Inc.
FAU - Kenney, Kimbra
AU  - Kenney K
AD  - Center for Neuroscience and Regenerative Medicine, Department of Neurology, 
      Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, 
      Bethesda, MD 20814, USA.
FAU - Amyot, Franck
AU  - Amyot F
AD  - Center for Neuroscience and Regenerative Medicine, Department of Neurology, 
      Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, 
      Bethesda, MD 20814, USA.
FAU - Haber, Margalit
AU  - Haber M
AD  - Center for Neuroscience and Regenerative Medicine, Department of Neurology, 
      Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, 
      Bethesda, MD 20814, USA.
FAU - Pronger, Angela
AU  - Pronger A
AD  - Center for Neuroscience and Regenerative Medicine, Department of Neurology, 
      Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, 
      Bethesda, MD 20814, USA.
FAU - Bogoslovsky, Tanya
AU  - Bogoslovsky T
AD  - Center for Neuroscience and Regenerative Medicine, Department of Neurology, 
      Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, 
      Bethesda, MD 20814, USA.
FAU - Moore, Carol
AU  - Moore C
AD  - Center for Neuroscience and Regenerative Medicine, Department of Neurology, 
      Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, 
      Bethesda, MD 20814, USA.
FAU - Diaz-Arrastia, Ramon
AU  - Diaz-Arrastia R
AD  - Center for Neuroscience and Regenerative Medicine, Department of Neurology, 
      Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, 
      Bethesda, MD 20814, USA. Electronic address: ramon.diaz-arrastia@usuhs.edu.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20150603
PL  - United States
TA  - Exp Neurol
JT  - Experimental neurology
JID - 0370712
SB  - IM
MH  - Animals
MH  - Brain/*blood supply/*pathology
MH  - Brain Injuries/*pathology
MH  - *Cerebrovascular Circulation/physiology
MH  - Humans
MH  - Microcirculation/physiology
MH  - Vascular System Injuries/*pathology
OTO - NOTNLM
OT  - Cerebral blood flow (CBF)
OT  - Cerebral microvasculature
OT  - Cerebrovascular reactivity (CVRx)
OT  - Chronic traumatic encephalopathy (CTE)
OT  - Controlled cortical impact (CCI)
OT  - Fluid percussion injury (FPI)
OT  - Functional Near InfraRed Spectroscopy (fNIRS)
OT  - Hypercapnia
OT  - MRI-arterial spin labeling (MRI-ASL)
OT  - Microvascular injury
OT  - Mild TBI (mTBI)
OT  - Neurovascular unit (NVU)
OT  - Single photon emission computed tomography (SPECT)
OT  - Susceptibility-weighted imaging (SWI)
OT  - Transcranial Doppler (TCD)
OT  - Traumatic brain injury (TBI)
OT  - Traumatic cerebral vascular injury (TCVI)
EDAT- 2015/06/07 06:00
MHDA- 2016/04/26 06:00
CRDT- 2015/06/07 06:00
PHST- 2015/03/05 00:00 [received]
PHST- 2015/05/19 00:00 [revised]
PHST- 2015/05/26 00:00 [accepted]
PHST- 2015/06/07 06:00 [entrez]
PHST- 2015/06/07 06:00 [pubmed]
PHST- 2016/04/26 06:00 [medline]
AID - S0014-4886(15)30006-6 [pii]
AID - 10.1016/j.expneurol.2015.05.019 [doi]
PST - ppublish
SO  - Exp Neurol. 2016 Jan;275 Pt 3:353-366. doi: 10.1016/j.expneurol.2015.05.019. Epub 
      2015 Jun 3.