PMID- 26049586
OWN - NLM
STAT- MEDLINE
DCOM- 20160411
LR  - 20221207
IS  - 1744-6880 (Electronic)
IS  - 1744-6872 (Linking)
VI  - 25
IP  - 8
DP  - 2015 Aug
TI  - A human leukocyte antigen locus haplotype confers risk for allopurinol-related 
      adverse effects in Caucasian patients with gout.
PG  - 412-5
LID - 10.1097/FPC.0000000000000147 [doi]
AB  - A human leukocyte antigen haplotype comprising six single-nucleotide 
      polymorphisms (SNPs) confers risk for allopurinol hypersensitivity syndrome in 
      Caucasians. The objective of the current study was to test for association of 
      this haplotype with other, less severe adverse effects (AEs) of allopurinol 
      therapy in a large New Zealand gout cohort. A total of 626 Caucasian and 766 
      Polynesian patients were genotyped for six SNPs (rs2844665, rs9263715, rs3130931, 
      rs3130501, rs3094188, rs9469003) using TaqMan SNP assays. The CACGAC haplotype 
      occurred at a frequency of 0.018 in Caucasians and 0.009 in Polynesians. The 
      CACGAC haplotype occurred at a significantly higher frequency in Caucasian 
      patients who experienced allopurinol-related AEs (13.3 vs. 1.7%, P=8.9e-06, odds 
      ratio=8.9, 95% confidence interval 2.8-27.9), but it was not associated with 
      overall allopurinol toxicity in Polynesians (P>0.05). Our study is the first to 
      demonstrate the potential utility of this six-SNP haplotype as a predictor of 
      milder allopurinol AEs.
FAU - Roberts, Rebecca L
AU  - Roberts RL
AD  - Departments of aSurgical Sciences bBiochemistry, Dunedin School of Medicine, 
      University of Otago, Dunedin cWellington Regional Rheumatology Unit, Hutt 
      Hospital, Lower Hutt dDepartment of Medicine, University of Auckland, Auckland 
      eDepartment of Medicine, University of Otago, Wellington fDepartment of Medicine, 
      University of Otago, Christchurch, New Zealand.
FAU - Wallace, Mary C
AU  - Wallace MC
FAU - Harrison, Andrew
AU  - Harrison A
FAU - Dalbeth, Nicola
AU  - Dalbeth N
FAU - Merriman, Tony R
AU  - Merriman TR
FAU - Stamp, Lisa K
AU  - Stamp LK
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Pharmacogenet Genomics
JT  - Pharmacogenetics and genomics
JID - 101231005
RN  - 0 (HLA Antigens)
RN  - 63CZ7GJN5I (Allopurinol)
SB  - IM
MH  - Allopurinol/*adverse effects
MH  - *Genetic Loci
MH  - *Genetic Predisposition to Disease
MH  - Gout/*genetics
MH  - HLA Antigens/*genetics
MH  - Haplotypes/*genetics
MH  - Humans
MH  - Polynesia
MH  - Risk Factors
MH  - White People/*genetics
EDAT- 2015/06/08 06:00
MHDA- 2016/04/12 06:00
CRDT- 2015/06/08 06:00
PHST- 2015/06/08 06:00 [entrez]
PHST- 2015/06/08 06:00 [pubmed]
PHST- 2016/04/12 06:00 [medline]
AID - 10.1097/FPC.0000000000000147 [doi]
PST - ppublish
SO  - Pharmacogenet Genomics. 2015 Aug;25(8):412-5. doi: 10.1097/FPC.0000000000000147.