PMID- 26050354
OWN - NLM
STAT- MEDLINE
DCOM- 20150817
LR  - 20200929
IS  - 0392-2936 (Print)
IS  - 0392-2936 (Linking)
VI  - 36
IP  - 2
DP  - 2015
TI  - Primary fallopian tube carcinoma--a retrospective analysis of 66 cases.
PG  - 161-7
AB  - BACKGROUND: Primary fallopian tube carcinoma (PFTC) is a rare malignant 
      gynecologic oncology. There was no consensus on the outcome related 
      clinicopathological characteristics. Present study aims to determine the 
      prognosis associate factors in PFTC. MATERIALS AND METHODS: In this retrospective 
      study, the authors identified 50 PFTC patients in Jiangsu Institute of Cancer 
      Research and 16 cases in the Affiliated People's Hospital of Inner Mongolia 
      Medical College between 1988 and 2013. Disease surveillance was conducted based 
      on the follow-up protocol of MD Anderson Cancer Center. Cox proportional hazards 
      model and log-rank test were used to assess the associations between potential 
      clinicpathologic characteristics and the survival durations. RESULTS: The median 
      progression free survival (PFS) and overall survival (OS) of PFTC were 36.9 and 
      62.7 months, respectively. FIGO Stage (p < 0.01, 0.01), grade (p = 0.02, 0.03), 
      tumor residual after initial debulking surgery (p = 0.05, 0.01), nadir CA-125 (p 
      = 0.01, 0.01) were independently related with PFS and OS. The PFS and OS of 
      patients with Stage II PFTC were similar as those with Stage III-IV (30.7 vs 28.3 
      and 61.9 vs 49.2 months, respectively) but poorer than those of Stage I cases 
      (N/A). The PFS of patients with paclitaxel-based chemotherapy was longer than 
      those with other regime (51.3 vs 33.1 months), but not OS (62.7 vs 42.6 months). 
      The outcome of patients underwent optimal initial cytoreduction surgery was 
      better than those of suboptimal ones (PFS 56.4 vs 21.2 months and OS 65.3 vs 47.9 
      months, respectively). CONCLUSIOn: PFTC patients with FIGO Stage II disease 
      should be regarded as advanced disease. Paclitaxel based chemotherapy was 
      associated with longer PFS but not OS in PFTC.
FAU - Liu, L
AU  - Liu L
FAU - Xu, X
AU  - Xu X
FAU - Jia, L
AU  - Jia L
FAU - Wei, M
AU  - Wei M
FAU - Qian, B
AU  - Qian B
FAU - Wu, Y
AU  - Wu Y
FAU - Shen, Y
AU  - Shen Y
FAU - Wang, X
AU  - Wang X
FAU - Pei, H
AU  - Pei H
FAU - Chen, X
AU  - Chen X
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Singapore
TA  - Eur J Gynaecol Oncol
JT  - European journal of gynaecological oncology
JID - 8100357
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Disease-Free Survival
MH  - Fallopian Tube Neoplasms/mortality/pathology/*therapy
MH  - Female
MH  - Humans
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - Proportional Hazards Models
MH  - Retrospective Studies
EDAT- 2015/06/09 06:00
MHDA- 2015/08/19 06:00
CRDT- 2015/06/09 06:00
PHST- 2015/06/09 06:00 [entrez]
PHST- 2015/06/09 06:00 [pubmed]
PHST- 2015/08/19 06:00 [medline]
PST - ppublish
SO  - Eur J Gynaecol Oncol. 2015;36(2):161-7.