PMID- 26051189
OWN - NLM
STAT- MEDLINE
DCOM- 20160629
LR  - 20161018
IS  - 1768-3122 (Electronic)
IS  - 0248-8663 (Linking)
VI  - 36
IP  - 10
DP  - 2015 Oct
TI  - [Survey of the prescriptions of proton pump inhibitors in patients admitted in an 
      internal medicine ward: how is the compliance to the French guidelines?].
PG  - 651-7
LID - S0248-8663(15)00463-4 [pii]
LID - 10.1016/j.revmed.2015.04.014 [doi]
AB  - PURPOSE: In June 2009, the national French authority for Health reported many 
      off-label uses of proton pump inhibitors (PPI). Our objective was to analyse the 
      justification and modalities of PPI prescriptions in patients before their 
      admission in a department of internal medicine. METHODS: Data were prospectively 
      collected during 5months. At admission, all prescriptions of PPI by general 
      practitioners (GP) were recorded. The accordance of the prescriptions with the 
      marketing authorization indications and the French guidelines in terms of 
      duration of treatment or dosage was analyzed. These informations were obtained 
      from computerized medical records and, if necessary, by contacting GPs. RESULTS: 
      We collected 173 prescriptions. Fifty-six (32%) were in accordance with marketing 
      authorization indications and, among them, 15 prescriptions (9% of all) respected 
      the French guidelines about dosage and duration of treatment. One hundred and six 
      prescriptions (61%) were not adequate and among them an off-label use was 
      notified in 91 (53% of all); among them 33% for simple dyspeptic disorders, 23% 
      for the prevention of NSAID-induced lesions in patients without risk factors, and 
      finally 17% for the prevention of stress ulcer. Fifty-two prescriptions (30%) 
      were unclassified due to incomplete data. CONCLUSION: Our study showed that a 
      vast majority of the prescriptions for PPIs are not in accordance with French 
      guidelines. Preventive actions against abusive prescriptions, withdrawal 
      strategies or replacement of already prescribed PPIs should be implemented to 
      reduce the risk of side effects and the economic impact of long term use of PPIs.
CI  - Copyright (c) 2015 Societe nationale francaise de medecine interne (SNFMI). 
      Published by Elsevier SAS. All rights reserved.
FAU - Sauvaget, L
AU  - Sauvaget L
AD  - Service de pharmacie hospitaliere, hopital Saint-Andre, CHU de Bordeaux, 1, rue 
      Jean-Burguet, 33075 Bordeaux, France. Electronic address: 
      lucie.sauvaget@gmail.com.
FAU - Rolland, L
AU  - Rolland L
AD  - Service de medecine interne (unites 22, 23, 26), hopital Saint-Andre, CHU de 
      Bordeaux, 1, rue Jean-Burguet, 33075 Bordeaux, France.
FAU - Dabadie, S
AU  - Dabadie S
AD  - Service de pharmacie hospitaliere, hopital Saint-Andre, CHU de Bordeaux, 1, rue 
      Jean-Burguet, 33075 Bordeaux, France.
FAU - Desblaches, J
AU  - Desblaches J
AD  - Service de medecine interne (unites 22, 23, 26), hopital Saint-Andre, CHU de 
      Bordeaux, 1, rue Jean-Burguet, 33075 Bordeaux, France.
FAU - Bernard, N
AU  - Bernard N
AD  - Service de medecine interne (unites 22, 23, 26), hopital Saint-Andre, CHU de 
      Bordeaux, 1, rue Jean-Burguet, 33075 Bordeaux, France.
FAU - Vandenhende, M-A
AU  - Vandenhende MA
AD  - Service de medecine interne (unites 22, 23, 26), hopital Saint-Andre, CHU de 
      Bordeaux, 1, rue Jean-Burguet, 33075 Bordeaux, France.
FAU - Bonnet, F
AU  - Bonnet F
AD  - Service de medecine interne (unites 22, 23, 26), hopital Saint-Andre, CHU de 
      Bordeaux, 1, rue Jean-Burguet, 33075 Bordeaux, France.
FAU - Pedeboscq, S
AU  - Pedeboscq S
AD  - Service de pharmacie hospitaliere, hopital Saint-Andre, CHU de Bordeaux, 1, rue 
      Jean-Burguet, 33075 Bordeaux, France.
FAU - Morlat, P
AU  - Morlat P
AD  - Service de medecine interne (unites 22, 23, 26), hopital Saint-Andre, CHU de 
      Bordeaux, 1, rue Jean-Burguet, 33075 Bordeaux, France.
LA  - fre
PT  - English Abstract
PT  - Journal Article
PT  - Observational Study
TT  - Rapport sur l'utilisation des inhibiteurs de la pompe a protons : les 
      recommandations francaises sont-elles respectees ?
DEP - 20150604
PL  - France
TA  - Rev Med Interne
JT  - La Revue de medecine interne
JID - 8101383
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Female
MH  - France/epidemiology
MH  - Guideline Adherence/standards/*statistics & numerical data
MH  - Humans
MH  - *Internal Medicine/statistics & numerical data
MH  - Male
MH  - Middle Aged
MH  - Patient Admission/*statistics & numerical data
MH  - Practice Patterns, Physicians'/*statistics & numerical data
MH  - Proton Pump Inhibitors/*therapeutic use
MH  - Surveys and Questionnaires
OTO - NOTNLM
OT  - Drug utilization review
OT  - Effets indesirables
OT  - Good clinical practice guidelines
OT  - Guide de bonnes pratiques
OT  - Inhibiteurs de la pompe a protons
OT  - Proton pump inhibitors
OT  - Revue des pratiques de prescription des medicaments
OT  - Side effects
EDAT- 2015/06/09 06:00
MHDA- 2016/06/30 06:00
CRDT- 2015/06/09 06:00
PHST- 2014/07/21 00:00 [received]
PHST- 2015/04/07 00:00 [revised]
PHST- 2015/04/29 00:00 [accepted]
PHST- 2015/06/09 06:00 [entrez]
PHST- 2015/06/09 06:00 [pubmed]
PHST- 2016/06/30 06:00 [medline]
AID - S0248-8663(15)00463-4 [pii]
AID - 10.1016/j.revmed.2015.04.014 [doi]
PST - ppublish
SO  - Rev Med Interne. 2015 Oct;36(10):651-7. doi: 10.1016/j.revmed.2015.04.014. Epub 
      2015 Jun 4.