PMID- 26051630
OWN - NLM
STAT- MEDLINE
DCOM- 20151209
LR  - 20220129
IS  - 1878-1810 (Electronic)
IS  - 1931-5244 (Print)
IS  - 1878-1810 (Linking)
VI  - 166
IP  - 4
DP  - 2015 Oct
TI  - Connexin and pannexin signaling in gastrointestinal and liver disease.
PG  - 332-43
LID - S1931-5244(15)00172-3 [pii]
LID - 10.1016/j.trsl.2015.05.005 [doi]
AB  - Gap junctions, which mediate intercellular communication, are key players in 
      digestive homeostasis. They are also frequently involved in gastrointestinal and 
      liver pathology. This equally holds true for connexin (Cx) hemichannels, the 
      structural precursors of gap junctions, and pannexin (Panx) channels, Cx-like 
      proteins assembled in a hemichannel configuration. Both Cx hemichannels and Panx 
      channels facilitate extracellular communication and drive a number of 
      deteriorative processes, such as cell death and inflammation. Cxs, Panxs, and 
      their channels underlie a wide spectrum of gastrointestinal and liver diseases, 
      including gastritis and peptic ulcer disease, inflammatory intestinal conditions, 
      acute liver failure, cholestasis, hepatitis and steatosis, liver fibrosis and 
      cirrhosis, infectious gastrointestinal pathologies, and gastrointestinal and 
      liver cancer. This could open promising perspectives for the characterization of 
      new targets and biomarkers for therapeutic and diagnostic clinical purposes in 
      the area of gastroenterology and hepatology.
CI  - Copyright (c) 2015 Elsevier Inc. All rights reserved.
FAU - Maes, Michael
AU  - Maes M
AD  - Department of In Vitro Toxicology and Dermato-Cosmetology, Vrije Universiteit 
      Brussel, Brussels, Belgium.
FAU - Crespo Yanguas, Sara
AU  - Crespo Yanguas S
AD  - Department of In Vitro Toxicology and Dermato-Cosmetology, Vrije Universiteit 
      Brussel, Brussels, Belgium.
FAU - Willebrords, Joost
AU  - Willebrords J
AD  - Department of In Vitro Toxicology and Dermato-Cosmetology, Vrije Universiteit 
      Brussel, Brussels, Belgium.
FAU - Cogliati, Bruno
AU  - Cogliati B
AD  - Department of Pathology, School of Veterinary Medicine and Animal Science, 
      University of Sao Paulo, Sao Paulo, Brazil.
FAU - Vinken, Mathieu
AU  - Vinken M
AD  - Department of In Vitro Toxicology and Dermato-Cosmetology, Vrije Universiteit 
      Brussel, Brussels, Belgium. Electronic address: mvinken@vub.ac.be.
LA  - eng
GR  - 335476/ERC_/European Research Council/International
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20150516
PL  - United States
TA  - Transl Res
JT  - Translational research : the journal of laboratory and clinical medicine
JID - 101280339
RN  - 0 (Connexins)
RN  - 0 (Nerve Tissue Proteins)
SB  - IM
MH  - Animals
MH  - Connexins/*metabolism
MH  - Gastrointestinal Diseases/*metabolism
MH  - Humans
MH  - Liver Diseases/*metabolism
MH  - Nerve Tissue Proteins/*metabolism
MH  - *Signal Transduction
PMC - PMC4570182
MID - EMS64928
OID - NLM: EMS64928
EDAT- 2015/06/09 06:00
MHDA- 2015/12/15 06:00
PMCR- 2016/04/01
CRDT- 2015/06/09 06:00
PHST- 2015/03/23 00:00 [received]
PHST- 2015/04/29 00:00 [revised]
PHST- 2015/05/08 00:00 [accepted]
PHST- 2015/06/09 06:00 [entrez]
PHST- 2015/06/09 06:00 [pubmed]
PHST- 2015/12/15 06:00 [medline]
PHST- 2016/04/01 00:00 [pmc-release]
AID - S1931-5244(15)00172-3 [pii]
AID - 10.1016/j.trsl.2015.05.005 [doi]
PST - ppublish
SO  - Transl Res. 2015 Oct;166(4):332-43. doi: 10.1016/j.trsl.2015.05.005. Epub 2015 
      May 16.