PMID- 26052234 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20150608 LR - 20201001 IS - 1179-5468 (Print) IS - 1179-5468 (Electronic) IS - 1179-5468 (Linking) VI - 9 IP - Suppl 2 DP - 2015 TI - Complications of Continuous-Flow Mechanical Circulatory Support Devices. PG - 15-21 LID - 10.4137/CMC.S19708 [doi] AB - Left ventricular assist devices (LVADs), more importantly the continuous-flow subclass, have revolutionized the medical field by improving New York Heart Association (NYHA) functional class status, quality of life, and survival rates in patients with advanced systolic heart failure. From the first pulsatile device to modern day continuous-flow devices, LVADs have continued to improve, but they are still associated with several complications. These complications include infection, bleeding, thrombosis, hemolysis, aortic valvular dysfunction, right heart failure, and ventricular arrhythmias. In this article, we aim to review these complications to understand the most appropriate approach for their prevention and to discuss the available therapeutic modalities. FAU - Patel, Harsh AU - Patel H AD - Department of Internal Medicine, SUNY Downstate School of Medicine, Brooklyn, NY, USA. FAU - Madanieh, Raef AU - Madanieh R AD - St. Francis Hospital - The Heart Center , Center for Advanced Cardiac Therapeutics, Roslyn, NY, USA. FAU - Kosmas, Constantine E AU - Kosmas CE AD - Icahn School of Medicine at Mount Sinai, Zena and Michael A. Wiener Cardiovascular Institute, New York, NY, USA. FAU - Vatti, Satya K AU - Vatti SK AD - St. Francis Hospital - The Heart Center , Center for Advanced Cardiac Therapeutics, Roslyn, NY, USA. FAU - Vittorio, Timothy J AU - Vittorio TJ AD - St. Francis Hospital - The Heart Center , Center for Advanced Cardiac Therapeutics, Roslyn, NY, USA. LA - eng PT - Journal Article PT - Review DEP - 20150521 PL - United States TA - Clin Med Insights Cardiol JT - Clinical Medicine Insights. Cardiology JID - 101525768 PMC - PMC4441367 OTO - NOTNLM OT - aortic insufficiency OT - bleeding OT - continuous-flow OT - infection OT - left ventricular assist device OT - pulsatile-flow OT - right ventricular failure OT - thrombosis OT - ventricular arrhythmias EDAT- 2015/06/09 06:00 MHDA- 2015/06/09 06:01 PMCR- 2015/05/21 CRDT- 2015/06/09 06:00 PHST- 2014/10/29 00:00 [received] PHST- 2014/12/01 00:00 [revised] PHST- 2014/12/06 00:00 [accepted] PHST- 2015/06/09 06:00 [entrez] PHST- 2015/06/09 06:00 [pubmed] PHST- 2015/06/09 06:01 [medline] PHST- 2015/05/21 00:00 [pmc-release] AID - cmc-suppl.2-2015-015 [pii] AID - 10.4137/CMC.S19708 [doi] PST - epublish SO - Clin Med Insights Cardiol. 2015 May 21;9(Suppl 2):15-21. doi: 10.4137/CMC.S19708. eCollection 2015.