PMID- 26052894
OWN - NLM
STAT- MEDLINE
DCOM- 20160204
LR  - 20220317
IS  - 1930-739X (Electronic)
IS  - 1930-7381 (Linking)
VI  - 23
IP  - 7
DP  - 2015 Jul
TI  - Increased NOD1, but not NOD2, activity in subcutaneous adipose tissue from 
      patients with metabolic syndrome.
PG  - 1394-400
LID - 10.1002/oby.21113 [doi]
AB  - OBJECTIVE: Nucleotide-binding oligomerization domain (NOD) protein, as 
      cytoplasmic receptor of the innate immune response, plays an important role in 
      adipose inflammation and insulin resistance in obesity. Our objective was to 
      examine adipose tissue (AT) NOD in nascent metabolic syndrome (MetS) patients and 
      to investigate its association with MetS features. METHODS: Thirty-four MetS 
      subjects and 31 controls were recruited. Fasting blood was collected, and 
      abdominal subcutaneous AT was obtained by biopsy for NOD1/NOD2 expression and 
      activity. RESULTS: MetS subjects showed significantly increased expression for 
      NOD1 on adipose depots as compared to controls. In addition to increased 
      expression of downstream signaling mediators RIPK2 and NF-kappaB p65 nuclear 
      translocation, there was remarkably higher release of monocyte chemotactic 
      protein1 (MCP-1), interleukin (IL)-6, and IL-8 in MetS versus controls following 
      priming of the isolated adipocytes with NOD1 ligand iE-DAP. With regard to NOD2, 
      the differences between the two groups were not significant in either basal state 
      or after activation. Increased NOD1 positively correlated with waist 
      circumference. NOD1 was also correlated with HbA1c and HOMA-IR. NOD1 positively 
      correlated with serum levels of IL-6, MCP-1, and NF-kappaB activity. CONCLUSIONS: 
      Activation of the innate immune pathway via NOD1 may be partially responsible for 
      the increased systemic inflammation and insulin resistance in MetS.
CI  - (c) 2015 The Obesity Society.
FAU - Zhou, Yi-Jun
AU  - Zhou YJ
AD  - Department of Endocrinology and Metabolism, Fourth Affiliated Hospital, China 
      Medical University, Shenyang, Liaoning, China.
FAU - Liu, Cong
AU  - Liu C
AD  - Department of Endocrinology and Metabolism, Shengjing Hospital, China Medical 
      University, Shenyang, Liaoning, China.
FAU - Li, Chun-Li
AU  - Li CL
AD  - Department of Endocrinology and Metabolism, Fourth Affiliated Hospital, China 
      Medical University, Shenyang, Liaoning, China.
FAU - Song, Yu-Ling
AU  - Song YL
AD  - Department of Endocrinology and Metabolism, Fourth Affiliated Hospital, China 
      Medical University, Shenyang, Liaoning, China.
FAU - Tang, Yin-Si
AU  - Tang YS
AD  - Department of Endocrinology and Metabolism, Fourth Affiliated Hospital, China 
      Medical University, Shenyang, Liaoning, China.
FAU - Zhou, Hui
AU  - Zhou H
AD  - Department of Endocrinology and Metabolism, Fourth Affiliated Hospital, China 
      Medical University, Shenyang, Liaoning, China.
FAU - Li, Ai
AU  - Li A
AD  - Department of Endocrinology and Metabolism, Fourth Affiliated Hospital, China 
      Medical University, Shenyang, Liaoning, China.
FAU - Li, Yan
AU  - Li Y
AD  - Department of Endocrinology and Metabolism, Fourth Affiliated Hospital, China 
      Medical University, Shenyang, Liaoning, China.
FAU - Weng, Yang
AU  - Weng Y
AD  - Department of Endocrinology and Metabolism, Fourth Affiliated Hospital, China 
      Medical University, Shenyang, Liaoning, China.
FAU - Zheng, Fang-Ping
AU  - Zheng FP
AD  - Department of Endocrinology and Metabolism, Fourth Affiliated Hospital, China 
      Medical University, Shenyang, Liaoning, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150605
PL  - United States
TA  - Obesity (Silver Spring)
JT  - Obesity (Silver Spring, Md.)
JID - 101264860
RN  - 0 (Cytokines)
RN  - 0 (Inflammation Mediators)
RN  - 0 (Nod1 Signaling Adaptor Protein)
RN  - 0 (Nod2 Signaling Adaptor Protein)
RN  - EC 2.7.11.1 (RIPK2 protein, human)
RN  - EC 2.7.11.1 (Receptor-Interacting Protein Serine-Threonine Kinase 2)
SB  - IM
MH  - Adipocytes/metabolism
MH  - Adult
MH  - Cytokines/metabolism
MH  - Female
MH  - Humans
MH  - Immunity, Innate
MH  - Inflammation/metabolism
MH  - Inflammation Mediators/metabolism
MH  - Insulin Resistance/physiology
MH  - Male
MH  - Metabolic Syndrome/*metabolism
MH  - Middle Aged
MH  - Nod1 Signaling Adaptor Protein/genetics/*metabolism
MH  - Nod2 Signaling Adaptor Protein/genetics/*metabolism
MH  - Obesity/metabolism
MH  - Receptor-Interacting Protein Serine-Threonine Kinase 2/metabolism
MH  - Signal Transduction/genetics
MH  - Subcutaneous Fat/*metabolism
MH  - Waist Circumference/genetics
EDAT- 2015/06/09 06:00
MHDA- 2016/02/05 06:00
CRDT- 2015/06/09 06:00
PHST- 2014/10/30 00:00 [received]
PHST- 2015/03/03 00:00 [accepted]
PHST- 2015/06/09 06:00 [entrez]
PHST- 2015/06/09 06:00 [pubmed]
PHST- 2016/02/05 06:00 [medline]
AID - 10.1002/oby.21113 [doi]
PST - ppublish
SO  - Obesity (Silver Spring). 2015 Jul;23(7):1394-400. doi: 10.1002/oby.21113. Epub 
      2015 Jun 5.