PMID- 26053308
OWN - NLM
STAT- MEDLINE
DCOM- 20160407
LR  - 20161126
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 277
IP  - 3
DP  - 2015 Dec
TI  - Radiofrequency Ablation Using a Multiple-Electrode Switching System for Lung 
      Tumors with 2.0-5.0-cm Maximum Diameter: Phase II Clinical Study.
PG  - 895-902
LID - 10.1148/radiol.2015141153 [doi]
AB  - PURPOSE: To prospectively evaluate the safety and effectiveness of radiofrequency 
      ablation (RFA) by using a multiple-electrode switching system to treat 2.0-5.0-cm 
      lung tumors. MATERIALS AND METHODS: The institutional review board approved this 
      prospective phase II study. Written informed consent was obtained from all 
      patients. Between September 2009 and July 2011, RFA using two or three 
      radiofrequency (RF) electrodes and a multiple-electrode switching system was 
      performed for malignant lung tumors with a maximum tumor diameter of 2.0-5.0 cm 
      in nonsurgical candidates. The primary endpoint was safety, as evaluated using 
      the Common Terminology Criteria for Adverse Events. Patients were observed for at 
      least 1 year. Local tumor progression and overall survival were analyzed with the 
      Kaplan-Meier method. RESULTS: Thirty-three patients (26 men, seven women; mean 
      age, 70.5 years +/- 10.0; age range, 46-87 years) with 35 lung tumors with a mean 
      maximum diameter of 3.0 cm +/- 0.7 (standard deviation; range, 2.0-4.4 cm) 
      underwent treatment in 35 sessions. No procedure-related death or grade 4 adverse 
      events (AEs) occurred. Grade 3 AEs occurred in four patients (12%), with pleural 
      effusion requiring chest tube placement in two patients, pneumothorax requiring 
      pleural adhesion in one patient, and pulmonary hemorrhage requiring pulmonary 
      artery coil embolization in one patient. Grade 2 AEs were detected in 13 patients 
      (39%). The 1-year local tumor progression and overall survival rates were 12.7% 
      (95% confidence interval [CI]: 1.0, 25.5) and 81.2% (95% CI: 67.6, 94.8). 
      CONCLUSION: RFA with a multiple-electrode switching system may be a safe 
      therapeutic option with which to treat 2.0-5.0-cm lung cancer tumors.
FAU - Kodama, Hiroshi
AU  - Kodama H
AD  - From the Department of Radiology, Mie University School of Medicine, 2-174 
      Edobashi, Tsu, Mie 514-8507, Japan.
FAU - Yamakado, Koichiro
AU  - Yamakado K
AD  - From the Department of Radiology, Mie University School of Medicine, 2-174 
      Edobashi, Tsu, Mie 514-8507, Japan.
FAU - Hasegawa, Takaaki
AU  - Hasegawa T
AD  - From the Department of Radiology, Mie University School of Medicine, 2-174 
      Edobashi, Tsu, Mie 514-8507, Japan.
FAU - Fujimori, Masashi
AU  - Fujimori M
AD  - From the Department of Radiology, Mie University School of Medicine, 2-174 
      Edobashi, Tsu, Mie 514-8507, Japan.
FAU - Yamanaka, Takashi
AU  - Yamanaka T
AD  - From the Department of Radiology, Mie University School of Medicine, 2-174 
      Edobashi, Tsu, Mie 514-8507, Japan.
FAU - Takaki, Haruyuki
AU  - Takaki H
AD  - From the Department of Radiology, Mie University School of Medicine, 2-174 
      Edobashi, Tsu, Mie 514-8507, Japan.
FAU - Uraki, Junji
AU  - Uraki J
AD  - From the Department of Radiology, Mie University School of Medicine, 2-174 
      Edobashi, Tsu, Mie 514-8507, Japan.
FAU - Nakatsuka, Atsuhiro
AU  - Nakatsuka A
AD  - From the Department of Radiology, Mie University School of Medicine, 2-174 
      Edobashi, Tsu, Mie 514-8507, Japan.
FAU - Sakuma, Hajime
AU  - Sakuma H
AD  - From the Department of Radiology, Mie University School of Medicine, 2-174 
      Edobashi, Tsu, Mie 514-8507, Japan.
LA  - eng
PT  - Clinical Trial, Phase II
PT  - Journal Article
DEP - 20150608
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
SB  - IM
MH  - Aged
MH  - Catheter Ablation/*instrumentation
MH  - Disease Progression
MH  - Female
MH  - Humans
MH  - Lung Neoplasms/diagnostic imaging/mortality/pathology/*surgery
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Tomography, X-Ray Computed
MH  - Treatment Outcome
EDAT- 2015/06/09 06:00
MHDA- 2016/04/08 06:00
CRDT- 2015/06/09 06:00
PHST- 2015/06/09 06:00 [entrez]
PHST- 2015/06/09 06:00 [pubmed]
PHST- 2016/04/08 06:00 [medline]
AID - 10.1148/radiol.2015141153 [doi]
PST - ppublish
SO  - Radiology. 2015 Dec;277(3):895-902. doi: 10.1148/radiol.2015141153. Epub 2015 Jun 
      8.