PMID- 26053355
OWN - NLM
STAT- MEDLINE
DCOM- 20160706
LR  - 20221207
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 5
DP  - 2015 Jun 8
TI  - Disrupted resting-state attentional networks in T2DM patients.
PG  - 11148
LID - 10.1038/srep11148 [doi]
LID - 11148
AB  - Although Type 2 diabetes mellitus (T2DM) is a well-recognized risk factor for 
      dementia, the neural mechanisms that underlie cognitive impairment in T2DM remain 
      unclear. This study uses resting-state functional magnetic resonance imaging 
      (fMRI) to examine attention network alterations in T2DM and their relationships 
      to impaired cognitive performance. Data-driven independent component analysis was 
      applied to resting-state fMRI data from 38 T2DM patients and 32 healthy controls 
      to identify the dorsal attention network (DAN) and ventral attention network 
      (VAN). Correlations were then determined among the resting-state functional 
      connectivity (rsFC), clinical data, and neuropsychological scores. The T2DM 
      patients exhibited decreased rsFC in the left middle frontal gyrus (MFG) and 
      bilateral inferior parietal lobe (IPL) of the DAN, as well as the left IPL and 
      right MFG/IFG of the VAN. In addition, the rsFC of the left MFG was inversely 
      correlated with the Trail Making Test-B scores; the rsFC of the left IPL was 
      positively correlated with the Digit Span Test scores but negatively correlated 
      with HbA1c; and the rsFC in the right precuneus was positively associated with 
      cognitive performance (without Bonferroni correction). In conclusion, T2DM 
      affects resting-state attentional networks, which may be related to reduced 
      attention and a hyperglycemic state.
FAU - Xia, Wenqing
AU  - Xia W
AD  - Department of Endocrinology, affiliated ZhongDa Hospital of Southeast University, 
      No. 87 Dingjiaqiao Road, Nanjing, China, 210009.
AD  - Medical school of Southeast University, No. 87 Dingjiaqiao Road, Nanjing, China, 
      210009.
AD  - Center for functional Neuroimaging, University of Pennsylvania, 3710 Hamilton 
      Walk, Philadelphia, PA, USA, 19104.
FAU - Wang, Shaohua
AU  - Wang S
AD  - Department of Endocrinology, affiliated ZhongDa Hospital of Southeast University, 
      No. 87 Dingjiaqiao Road, Nanjing, China, 210009.
FAU - Rao, Hengyi
AU  - Rao H
AD  - Center for functional Neuroimaging, University of Pennsylvania, 3710 Hamilton 
      Walk, Philadelphia, PA, USA, 19104.
FAU - Spaeth, Andrea M
AU  - Spaeth AM
AD  - Center for Sleep and Circadian Neurobiology, Perelman School of Medicine, 
      University of Pennsylvania, 3710 Hamilton Walk, Philadelphia, PA, 19104.
FAU - Wang, Pin
AU  - Wang P
AD  - Department of Endocrinology, affiliated ZhongDa Hospital of Southeast University, 
      No. 87 Dingjiaqiao Road, Nanjing, China, 210009.
FAU - Yang, Yue
AU  - Yang Y
AD  - Department of Endocrinology, affiliated ZhongDa Hospital of Southeast University, 
      No. 87 Dingjiaqiao Road, Nanjing, China, 210009.
FAU - Huang, Rong
AU  - Huang R
AD  - Department of Endocrinology, affiliated ZhongDa Hospital of Southeast University, 
      No. 87 Dingjiaqiao Road, Nanjing, China, 210009.
FAU - Cai, Rongrong
AU  - Cai R
AD  - Department of Endocrinology, affiliated ZhongDa Hospital of Southeast University, 
      No. 87 Dingjiaqiao Road, Nanjing, China, 210009.
FAU - Sun, Haixia
AU  - Sun H
AD  - Department of Endocrinology, affiliated ZhongDa Hospital of Southeast University, 
      No. 87 Dingjiaqiao Road, Nanjing, China, 210009.
LA  - eng
GR  - T32 HL007713/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150608
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (hemoglobin A1c protein, human)
SB  - IM
MH  - Aged
MH  - Attention/*physiology
MH  - Brain Mapping/*methods
MH  - Cognition/physiology
MH  - Dementia/*complications
MH  - Diabetes Mellitus, Type 2/blood/*etiology/metabolism
MH  - Female
MH  - Glycated Hemoglobin/analysis
MH  - Humans
MH  - Hyperglycemia/blood/pathology
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Neural Pathways/*physiology
MH  - Neuropsychological Tests
MH  - Parietal Lobe/physiology
MH  - Prefrontal Cortex/physiology
PMC - PMC4459168
COIS- The authors declare no competing financial interests.
EDAT- 2015/06/09 06:00
MHDA- 2016/07/07 06:00
PMCR- 2015/06/08
CRDT- 2015/06/09 06:00
PHST- 2014/10/24 00:00 [received]
PHST- 2015/05/14 00:00 [accepted]
PHST- 2015/06/09 06:00 [entrez]
PHST- 2015/06/09 06:00 [pubmed]
PHST- 2016/07/07 06:00 [medline]
PHST- 2015/06/08 00:00 [pmc-release]
AID - srep11148 [pii]
AID - 10.1038/srep11148 [doi]
PST - epublish
SO  - Sci Rep. 2015 Jun 8;5:11148. doi: 10.1038/srep11148.