PMID- 26054256
OWN - NLM
STAT- MEDLINE
DCOM- 20160422
LR  - 20190318
IS  - 1520-5851 (Electronic)
IS  - 0013-936X (Linking)
VI  - 49
IP  - 13
DP  - 2015 Jul 7
TI  - Association between Several Persistent Organic Pollutants in Serum and Adipokine 
      Levels in Breast Milk among Lactating Women of Korea.
PG  - 8033-40
LID - 10.1021/acs.est.5b00520 [doi]
AB  - Exposure to several persistent organic pollutants (POPs) has been linked to 
      alteration of lipid metabolism. Adipokines, such as leptin and adiponectin, are 
      hormones that play roles in lipid metabolism, and have been suggested as markers 
      of health effects that may lead to obesity. To date, only serum adipokines have 
      been associated with POPs exposure. In the present study, for the first time, the 
      associations between leptin and adiponectin in breast milk, and several POPs in 
      serum were investigated among 82 lactating Korean women between 25 and 46 years 
      of age. Breast milk adipokines are important because adipokine intake of infant 
      through breastfeeding may influence the growth of infants. The median 
      concentrations of leptin and adiponectin in skimmed milk of the Korean lactating 
      women were 17.9 ng/L and 16.5 mug/L, respectively. Leptin concentrations in breast 
      milk were negatively associated with  summation operatorhexachlorohexane (HCH), oxychlordane, 
       summation operatorchlordane, or 2,2',4,4',5,5'-hexachlorobiphenyl (CB 153) levels in maternal 
      serum. Linear relationships between adiponectin and POPs concentrations were not 
      observed, however, nonmonotonic relationship which showed generally positive 
      associations was suggested for p,p'-dichlorodiphenyltrichloroethane (DDT) and 
       summation operatorchlordane in quartile analysis. Our observations show that POPs at the current 
      level of exposure may be associated with the alteration of lipid metabolism among 
      lactating women. Implication of adipokine transfer to breastfed infants is of 
      concern and deserves further investigation.
FAU - Kim, Sunmi
AU  - Kim S
AD  - daggerSchool of Public Health, Seoul National University, Seoul 151-742, Republic of 
      Korea.
FAU - Park, Jeongim
AU  - Park J
AD  - double daggerCollege of Natural Sciences, Soonchunhyang University, Asan 336-745, Republic of 
      Korea.
FAU - Kim, Hai-Joong
AU  - Kim HJ
AD  -  section signCollege of Medicine, Korea University, Seoul 152-703, Republic of Korea.
FAU - Lee, Jeong Jae
AU  - Lee JJ
AD  -  parallelCollege of Medicine, Soonchunhyang University, Seoul 140-743, Republic of Korea.
FAU - Choi, Gyuyeon
AU  - Choi G
AD  -  parallelCollege of Medicine, Soonchunhyang University, Seoul 140-743, Republic of Korea.
FAU - Choi, Sooran
AU  - Choi S
AD  -  perpendicularCollege of Medicine, Inha University, Incheon 400-711, Republic of Korea.
FAU - Kim, Sungjoo
AU  - Kim S
AD  -  paragraph signCollege of Medicine, Hallym University, Anyang 431-796, Republic of Korea.
FAU - Kim, Su Young
AU  - Kim SY
AD  - nablaCollege of Medicine, Jeju National University, Jeju 690-756, Republic of Korea.
FAU - Lee, Duk Hee
AU  - Lee DH
AD  - #College of Medicine, Kyungpook National University, Daegu 700-721, Republic of 
      Korea.
FAU - Moon, Hyo-Bang
AU  - Moon HB
AD  - iCollege of Science and Technology, Hanyang University, Ansan 426-791, Republic 
      of Korea.
FAU - Kim, Sungkyoon
AU  - Kim S
AD  - daggerSchool of Public Health, Seoul National University, Seoul 151-742, Republic of 
      Korea.
FAU - Choi, Kyungho
AU  - Choi K
AD  - daggerSchool of Public Health, Seoul National University, Seoul 151-742, Republic of 
      Korea.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150625
PL  - United States
TA  - Environ Sci Technol
JT  - Environmental science & technology
JID - 0213155
RN  - 0 (ADIPOQ protein, human)
RN  - 0 (Adipokines)
RN  - 0 (Adiponectin)
RN  - 0 (Environmental Pollutants)
RN  - 0 (Leptin)
RN  - 12789-03-6 (Chlordan)
RN  - 27304-13-8 (oxychlordane)
RN  - 59NEE7PCAB (Hexachlorocyclohexane)
RN  - CIW5S16655 (DDT)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
RN  - ZRU0C9E32O (2,4,5,2',4',5'-hexachlorobiphenyl)
SB  - IM
MH  - Adipokines/*analysis
MH  - Adiponectin
MH  - Adult
MH  - *Breast Feeding
MH  - Chlordan/analogs & derivatives/blood
MH  - DDT/blood
MH  - Environmental Exposure/adverse effects/analysis
MH  - Environmental Pollutants/*blood
MH  - Female
MH  - Hexachlorocyclohexane/blood
MH  - Humans
MH  - Leptin/*analysis
MH  - Lipid Metabolism/drug effects
MH  - Middle Aged
MH  - Milk, Human/*chemistry
MH  - Polychlorinated Biphenyls/blood
MH  - Pregnancy
MH  - Republic of Korea
EDAT- 2015/06/10 06:00
MHDA- 2016/04/23 06:00
CRDT- 2015/06/10 06:00
PHST- 2015/06/10 06:00 [entrez]
PHST- 2015/06/10 06:00 [pubmed]
PHST- 2016/04/23 06:00 [medline]
AID - 10.1021/acs.est.5b00520 [doi]
PST - ppublish
SO  - Environ Sci Technol. 2015 Jul 7;49(13):8033-40. doi: 10.1021/acs.est.5b00520. 
      Epub 2015 Jun 25.