PMID- 26056280
OWN - NLM
STAT- MEDLINE
DCOM- 20151110
LR  - 20181113
IS  - 1091-6490 (Electronic)
IS  - 0027-8424 (Print)
IS  - 0027-8424 (Linking)
VI  - 112
IP  - 25
DP  - 2015 Jun 23
TI  - Spatial gradient in value representation along the medial prefrontal cortex 
      reflects individual differences in prosociality.
PG  - 7851-6
LID - 10.1073/pnas.1423895112 [doi]
AB  - Despite the importance of valuing another person's welfare for prosocial 
      behavior, currently we have only a limited understanding of how these values are 
      represented in the brain and, more importantly, how they give rise to individual 
      variability in prosociality. In the present study, participants underwent 
      functional magnetic resonance imaging while performing a prosocial learning task 
      in which they could choose to benefit themselves and/or another person. Choice 
      behavior indicated that participants valued the welfare of another person, 
      although less so than they valued their own welfare. Neural data revealed a 
      spatial gradient in activity within the medial prefrontal cortex (MPFC), such 
      that ventral parts predominantly represented self-regarding values and dorsal 
      parts predominantly represented other-regarding values. Importantly, compared 
      with selfish individuals, prosocial individuals showed a more gradual transition 
      from self-regarding to other-regarding value signals in the MPFC and stronger 
      MPFC-striatum coupling when they made choices for another person rather than for 
      themselves. The present study provides evidence of neural markers reflecting 
      individual differences in human prosociality.
FAU - Sul, Sunhae
AU  - Sul S
AD  - Department of Psychology, Korea University, Seoul 136-701, Republic of Korea;
FAU - Tobler, Philippe N
AU  - Tobler PN
AD  - Department of Economics, University of Zurich, CH-8006 Zurich, Switzerland;
FAU - Hein, Grit
AU  - Hein G
AD  - Department of Economics, University of Zurich, CH-8006 Zurich, Switzerland;
FAU - Leiberg, Susanne
AU  - Leiberg S
AD  - Department of Economics, University of Zurich, CH-8006 Zurich, Switzerland;
FAU - Jung, Daehyun
AU  - Jung D
AD  - Department of Brain and Cognitive Engineering, Korea University, Seoul 136-701, 
      Republic of Korea.
FAU - Fehr, Ernst
AU  - Fehr E
AD  - Department of Economics, University of Zurich, CH-8006 Zurich, Switzerland;
FAU - Kim, Hackjin
AU  - Kim H
AD  - Department of Psychology, Korea University, Seoul 136-701, Republic of Korea; 
      hackjinkim@korea.ac.kr.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150608
PL  - United States
TA  - Proc Natl Acad Sci U S A
JT  - Proceedings of the National Academy of Sciences of the United States of America
JID - 7505876
SB  - IM
MH  - Adult
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Prefrontal Cortex/*physiology
MH  - *Social Behavior
MH  - Young Adult
PMC - PMC4485092
OTO - NOTNLM
OT  - anterior insula
OT  - computational model
OT  - medial prefrontal cortex
OT  - reinforcement learning
OT  - striatum
COIS- The authors declare no conflict of interest.
EDAT- 2015/06/10 06:00
MHDA- 2015/11/11 06:00
PMCR- 2015/06/08
CRDT- 2015/06/10 06:00
PHST- 2015/06/10 06:00 [entrez]
PHST- 2015/06/10 06:00 [pubmed]
PHST- 2015/11/11 06:00 [medline]
PHST- 2015/06/08 00:00 [pmc-release]
AID - 1423895112 [pii]
AID - 201423895 [pii]
AID - 10.1073/pnas.1423895112 [doi]
PST - ppublish
SO  - Proc Natl Acad Sci U S A. 2015 Jun 23;112(25):7851-6. doi: 
      10.1073/pnas.1423895112. Epub 2015 Jun 8.