PMID- 26056423
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240323
IS  - 1088-4246 (Print)
IS  - 1099-1409 (Electronic)
IS  - 1088-4246 (Linking)
VI  - 19
IP  - 1-3
DP  - 2015 Jan-Mar
TI  - Reactions of a heme-superoxo complex toward a cuprous chelate and *NO((g)): CcO 
      and NOD chemistry.
PG  - 352-360
AB  - Following up on the characterization of a new (heme)Fe(III)-superoxide species 
      formed from the cryogenic oxygenation of a ferrous-heme (P(Py))Fe(II) (1) (P(Py) 
      = a tetraarylporphyrinate with a covalently tethered pyridine group as a 
      potential axial base), giving (P(Py))Fe(III)-O(2)(*-) (2) (Li Y et al., 
      Polyhedron 2013; 58: 60-64), we report here on (i) its use in forming a 
      cytochrome c oxidase (CcO) model compound, or (ii) in a reaction with nitrogen 
      monoxide (*NO; nitric oxide) to mimic nitric oxide dioxygenase (NOD) chemistry. 
      Reaction of (2) with the cuprous chelate [Cu(I)(AN)][B(C(6)F(5))(4)] (AN = 
      bis[3-(dimethylamino) propyl]amine) gives a meta-stable product 
      [(P(Py))Fe(III)-([Formula: see text])-Cu(II)(AN)][B(C(6)F(5))4] (3a), possessing 
      a high-spin iron(III) and Cu(II) side-on bridged peroxo moiety with a 
      mu-eta(2):eta(2)-binding motif. This complex thermally decays to a corresponding mu-oxo 
      complex [(P(Py))Fe(III)-(O(2-))-Cu(II)(AN)][B(C(6)F(5))4] (3). Both (3) and (3a) 
      have been characterized by UV-vis, (2)H NMR and EPR spectroscopies. When (2) is 
      exposed to *NO((g)), a ferric heme nitrato compound forms; if 
      2,4-di-tert-butylphenol is added prior to *NO((g)) exposure, phenol 
      ortho-nitration occurs with the iron product being the ferric hydroxide complex 
      (P(Py)) Fe(III)(OH) (5). The latter reactions mimic the action of NOD's.
FAU - Sharma, Savita K
AU  - Sharma SK
AD  - Department of Chemistry, Johns Hopkins University, Baltimore, MD 21218, USA.
FAU - Rogler, Patrick J
AU  - Rogler PJ
AD  - Department of Chemistry, Johns Hopkins University, Baltimore, MD 21218, USA.
FAU - Karlin, Kenneth D
AU  - Karlin KD
AD  - Department of Chemistry, Johns Hopkins University, Baltimore, MD 21218, USA.
LA  - eng
GR  - R01 GM060353/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PL  - Singapore
TA  - J Porphyr Phthalocyanines
JT  - Journal of porphyrins and phthalocyanines
JID - 9890997
PMC - PMC4457333
MID - NIHMS692072
OTO - NOTNLM
OT  - heme-copper-mu-oxo
OT  - heme-superoxo
OT  - high spin heme-copper peroxo
OT  - nitrate
OT  - peroxynitrite
EDAT- 2015/06/10 06:00
MHDA- 2015/06/10 06:01
PMCR- 2016/01/01
CRDT- 2015/06/10 06:00
PHST- 2015/06/10 06:00 [entrez]
PHST- 2015/06/10 06:00 [pubmed]
PHST- 2015/06/10 06:01 [medline]
PHST- 2016/01/01 00:00 [pmc-release]
AID - 10.1142/S108842461550025X [doi]
PST - ppublish
SO  - J Porphyr Phthalocyanines. 2015 Jan-Mar;19(1-3):352-360. doi: 
      10.1142/S108842461550025X.