PMID- 26056721
OWN - NLM
STAT- MEDLINE
DCOM- 20170301
LR  - 20170302
IS  - 1521-0464 (Electronic)
IS  - 1071-7544 (Linking)
VI  - 23
IP  - 8
DP  - 2016 Oct
TI  - Low molecular weight heparins for current and future uses: approaches for micro- 
      and nano-particulate delivery.
PG  - 2661-2667
AB  - Low molecular weight heparins (LMWHs), the anticoagulant drug of choice in many 
      indications, had been suggested as novel drug treatment for a range of diseases. 
      Their superior pharmacokinetic properties compared to unfractionated heparin 
      (UFH), motivated scientists to explore new delivery systems for improved 
      therapeutic outcomes. Micro- and nano-carriers, with the versatile nature and 
      characteristics of materials used for their fabrication, are able to surmount the 
      challenges opposed by their native structures. The present review discusses the 
      recent perspectives on the development of micro- and nano-particulate vectors for 
      the delivery of LMWHs through various routes. Special focus on the application of 
      the suggested systems, their characterization and the achieved improved 
      bioavailability will be given throughout the review.
FAU - Ibrahim, Shaimaa S
AU  - Ibrahim SS
AD  - a Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy , Ain 
      Shams University , Abbassyia, Cairo , Egypt.
FAU - Osman, Rihab
AU  - Osman R
AD  - a Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy , Ain 
      Shams University , Abbassyia, Cairo , Egypt.
FAU - Awad, Gehanne A S
AU  - Awad GA
AD  - a Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy , Ain 
      Shams University , Abbassyia, Cairo , Egypt.
FAU - Mortada, Nahed D
AU  - Mortada ND
AD  - a Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy , Ain 
      Shams University , Abbassyia, Cairo , Egypt.
FAU - Geneidy, Ahmed-Shawky
AU  - Geneidy AS
AD  - a Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy , Ain 
      Shams University , Abbassyia, Cairo , Egypt.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20150609
PL  - England
TA  - Drug Deliv
JT  - Drug delivery
JID - 9417471
RN  - 0 (Drug Carriers)
RN  - 0 (Heparin, Low-Molecular-Weight)
SB  - IM
MH  - Animals
MH  - Biological Availability
MH  - Drug Carriers/chemistry
MH  - Drug Delivery Systems/methods
MH  - Heparin, Low-Molecular-Weight/chemistry/*pharmacology/*therapeutic use
MH  - Humans
MH  - Nanoparticles/*chemistry
OTO - NOTNLM
OT  - Heparin
OT  - low molecular weight heparin
OT  - microparticles
OT  - nanoparticles
OT  - routes of administration
EDAT- 2015/06/10 06:00
MHDA- 2017/03/03 06:00
CRDT- 2015/06/10 06:00
PHST- 2015/06/10 06:00 [pubmed]
PHST- 2017/03/03 06:00 [medline]
PHST- 2015/06/10 06:00 [entrez]
AID - 10.3109/10717544.2015.1046570 [doi]
PST - ppublish
SO  - Drug Deliv. 2016 Oct;23(8):2661-2667. doi: 10.3109/10717544.2015.1046570. Epub 
      2015 Jun 9.