PMID- 26056792
OWN - NLM
STAT- MEDLINE
DCOM- 20151013
LR  - 20150718
IS  - 1536-3678 (Electronic)
IS  - 1077-4114 (Linking)
VI  - 37
IP  - 6
DP  - 2015 Aug
TI  - Respiratory Failure in Children With Hemato-oncological Diseases Admitted to the 
      PICU: A Single-center Experience.
PG  - 449-54
LID - 10.1097/MPH.0000000000000377 [doi]
AB  - Respiratory failure (RF) is a main cause of pediatric intensive care unit (PICU) 
      admission in children with hemato-oncological diseases. We present a 
      retrospective chart review of children admitted to our PICU because of RF 
      (January 2006 to December 2010). The aims of this study are the following: (1) to 
      describe the demographical and clinical characteristics and respiratory 
      management of these children; and (2) to identify the factors associated with 
      mechanical ventilation (MV) and mortality. A total of 69 patients, encompassing 
      88 episodes, were included (55/88 cases were hypoxemic RF). The first respiratory 
      support at PICU admission was, in decreasing order of frequency, high-flow oxygen 
      nasal cannula (HFNC; 50/88), noninvasive ventilation (NIV; 13/88), and oxygen 
      nasal cannula (16/88). MV was necessary in 47/88 episodes, 38/47 after another 
      respiratory support. In 18/28 children with initial NIV, MV was required later. 
      MV was associated with O-PRISM score, NIV requirement, suspected respiratory 
      infection, and days of PICU treatment. Patients without MV showed an increased 
      survival rate (P=0.001). In summary, the hypoxemic RF was the main cause of PICU 
      admission, and HFNC or NIV was almost always the first respiratory support. The 
      use of MV was associated with a higher mortality rate. The utility of precocious 
      HFNC or NIV should be investigated in larger clinical studies.
FAU - Garcia-Salido, Alberto
AU  - Garcia-Salido A
AD  - Pediatric Critical Care Unit, Hospital Infantil Universitario Nino Jesus, Madrid, 
      Spain.
FAU - Mastro-Martinez, Ignacio
AU  - Mastro-Martinez I
FAU - Cabeza-Martin, Beatriz
AU  - Cabeza-Martin B
FAU - Onoro, Gonzalo
AU  - Onoro G
FAU - Nieto-Moro, Montserrat
AU  - Nieto-Moro M
FAU - Iglesias-Bouzas, Maria I
AU  - Iglesias-Bouzas MI
FAU - Serrano-Gonzalez, Ana
AU  - Serrano-Gonzalez A
FAU - Casado-Flores, Juan
AU  - Casado-Flores J
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PL  - United States
TA  - J Pediatr Hematol Oncol
JT  - Journal of pediatric hematology/oncology
JID - 9505928
SB  - IM
MH  - Child
MH  - Female
MH  - Follow-Up Studies
MH  - Hematologic Neoplasms/*complications
MH  - Hospitalization
MH  - Humans
MH  - *Intensive Care Units, Pediatric
MH  - Male
MH  - Prognosis
MH  - Respiration, Artificial
MH  - Respiratory Insufficiency/*etiology/mortality/therapy
MH  - Retrospective Studies
MH  - Survival Rate
EDAT- 2015/06/10 06:00
MHDA- 2015/10/16 06:00
CRDT- 2015/06/10 06:00
PHST- 2015/06/10 06:00 [entrez]
PHST- 2015/06/10 06:00 [pubmed]
PHST- 2015/10/16 06:00 [medline]
AID - 10.1097/MPH.0000000000000377 [doi]
PST - ppublish
SO  - J Pediatr Hematol Oncol. 2015 Aug;37(6):449-54. doi: 
      10.1097/MPH.0000000000000377.