PMID- 26057605
OWN - NLM
STAT- MEDLINE
DCOM- 20160428
LR  - 20150729
IS  - 1944-0057 (Electronic)
IS  - 1944-0057 (Linking)
VI  - 32
IP  - 8
DP  - 2015
TI  - Migration of Tinuvin P and Irganox 3114 into milk and the corresponding 
      authorised food simulant.
PG  - 1358-66
LID - 10.1080/19440049.2015.1055523 [doi]
AB  - Migration of Tinuvin P (UV stabiliser) and Irganox 3114 (antioxidant) from 
      high-density polyethylene (HDPE) was studied. HDPE pieces were soaked in either 
      milk (1.5% or 3.5% fat content) or 50% (v/v) ethanol-water mixture - the food 
      simulant for milk as specified in Regulation No. 10/2011/EC. The obtained 
      extracts were analysed by LC-MS/MS. For statistical assessment variography was 
      used. It proved to be a useful tool for making a distinction between the early 
      migration range and the equilibrium, despite the variance of the data. Regulation 
      No. 10/2011/EC specifies 10 days of contact time for milk at 5 degrees C. Our experiments 
      with the food simulant with 24 dm(2) kg(-1) surface/mass ratio showed that both 
      Tinuvin P and Irganox 3114 need less than 1 h to reach equilibrium. Furthermore, 
      10-day experiments with daily sampling showed that these additives are stable in 
      milk, as well as in the food simulant. The effect of the concentration of the 
      additives in HDPE was studied in the 0.01-5% (m/m) range. For both Tinuvin P and 
      Irganox 3114 and all three extractants the migrated amount became independent of 
      the concentration of the additive in the HDPE approximately at 1% (m/m). For 
      Tinuvin P the food simulant gave a close estimate for the milk samples. However, 
      using the food simulant for modelling the migration of Irganox 3114 into milk 
      gave an overestimation with a factor of minimum 3.5. In the case of Tinuvin P 
      special care must be taken, since the recommended amount in the HDPE can result 
      in additive concentrations near or even over the specific migration limit (SML). 
      However, Irganox 3114 cannot reach the SML either in milk or in the food 
      simulant.
FAU - Bodai, Zsolt
AU  - Bodai Z
AD  - a Joint Research and Training Laboratory on Separation Techniques (EKOL) , Eotvos 
      Lorand University , Budapest 1117 , Hungary.
FAU - Kirchkeszner, Csaba
AU  - Kirchkeszner C
FAU - Novak, Marton
AU  - Novak M
FAU - Nyiri, Zoltan
AU  - Nyiri Z
FAU - Kovacs, Jozsef
AU  - Kovacs J
FAU - Magyar, Norbert
AU  - Magyar N
FAU - Ivan, Bela
AU  - Ivan B
FAU - Rikker, Tamas
AU  - Rikker T
FAU - Eke, Zsuzsanna
AU  - Eke Z
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150618
PL  - England
TA  - Food Addit Contam Part A Chem Anal Control Expo Risk Assess
JT  - Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & 
      risk assessment
JID - 101485040
RN  - 0 (Irganox 3114)
RN  - 0 (Triazoles)
RN  - 1P9D0Z171K (Butylated Hydroxytoluene)
RN  - 2440-22-4 (benazol P)
RN  - 9002-88-4 (Polyethylene)
SB  - IM
MH  - Animals
MH  - Butylated Hydroxytoluene/*analogs & derivatives/analysis
MH  - Chromatography, High Pressure Liquid
MH  - Food Contamination/*analysis
MH  - Food Packaging/*instrumentation
MH  - Milk/*chemistry
MH  - Polyethylene/chemistry
MH  - Reproducibility of Results
MH  - Tandem Mass Spectrometry
MH  - Triazoles/*analysis
OTO - NOTNLM
OT  - LC-MS
OT  - UV stabiliser
OT  - additives
OT  - antioxidant
OT  - food simulant
OT  - migration
OT  - milk
OT  - semi-variogram
EDAT- 2015/06/10 06:00
MHDA- 2016/04/29 06:00
CRDT- 2015/06/10 06:00
PHST- 2015/06/10 06:00 [entrez]
PHST- 2015/06/10 06:00 [pubmed]
PHST- 2016/04/29 06:00 [medline]
AID - 10.1080/19440049.2015.1055523 [doi]
PST - ppublish
SO  - Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2015;32(8):1358-66. 
      doi: 10.1080/19440049.2015.1055523. Epub 2015 Jun 18.