PMID- 26057756
OWN - NLM
STAT- MEDLINE
DCOM- 20151204
LR  - 20150610
IS  - 2325-8179 (Electronic)
IS  - 2325-8160 (Linking)
VI  - 46
IP  - 5
DP  - 2015 May
TI  - Combined Nonmydriatic Spectral-Domain Optical Coherence Tomography and 
      Nonmydriatic Fundus Photography for the Detection of Age-Related Macular 
      Degeneration Changes.
PG  - 531-7
LID - 10.3928/23258160-20150521-04 [doi]
AB  - BACKGROUND AND OBJECTIVE: Nonmydriatic fundus photography (FP) has been a 
      suboptimal tool for detecting age-related macular degeneration (AMD) changes. 
      This study sought to enhance the detection of AMD changes by combining 
      nonmydriatic FP with nonmydriatic spectral-domain optical coherence tomography 
      (SD-OCT). PATIENTS AND METHODS: The study population included 249 patients aged 
      65 years and older who were assessed for AMD changes using standard mydriatic 
      biomicroscopic fundus examination. Each eye then underwent nonmydriatic FP in one 
      session followed 1 week later with nonmydriatic FP coupled with nonmydriatic 
      SD-OCT. Images were interpreted for detection of AMD changes, and findings were 
      compared to the original mydriatic biomicroscopic examination. RESULTS: 
      Nonmydriatic FP had 64% sensitivity, 97% specificity, and a kappa value of 0.67 
      in detecting AMD changes compared with the traditional mydriatic biomicroscopic 
      examination. Combined nonmydriatic FP and nonmydriatic SD-OCT increased 
      sensitivity to 91.5%, specificity to 98.6%, and kappa to 0.91. CONCLUSION: The 
      addition of nonmydriatic SD-OCT to nonmydriatic FP enhances the detection of AMD 
      changes.
CI  - Copyright 2015, SLACK Incorporated.
FAU - Salti, Haytham I
AU  - Salti HI
FAU - Antonios, Rafic S
AU  - Antonios RS
FAU - Haddad, Sandra S
AU  - Haddad SS
FAU - Hamam, Rola N
AU  - Hamam RN
FAU - Bashshur, Ziad F
AU  - Bashshur ZF
FAU - Ghazi, Nicola G
AU  - Ghazi NG
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Ophthalmic Surg Lasers Imaging Retina
JT  - Ophthalmic surgery, lasers & imaging retina
JID - 101599215
RN  - 0 (Mydriatics)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - *Diagnostic Techniques, Ophthalmological
MH  - False Negative Reactions
MH  - Female
MH  - Geographic Atrophy/*diagnosis
MH  - Humans
MH  - Male
MH  - Mydriatics/administration & dosage
MH  - *Photography
MH  - Predictive Value of Tests
MH  - Pupil/drug effects
MH  - Reproducibility of Results
MH  - Retina/*pathology
MH  - Sensitivity and Specificity
MH  - *Tomography, Optical Coherence
MH  - Wet Macular Degeneration/*diagnosis
EDAT- 2015/06/10 06:00
MHDA- 2015/12/15 06:00
CRDT- 2015/06/10 06:00
PHST- 2014/12/03 00:00 [received]
PHST- 2015/03/04 00:00 [accepted]
PHST- 2015/06/10 06:00 [entrez]
PHST- 2015/06/10 06:00 [pubmed]
PHST- 2015/12/15 06:00 [medline]
AID - 10.3928/23258160-20150521-04 [doi]
PST - ppublish
SO  - Ophthalmic Surg Lasers Imaging Retina. 2015 May;46(5):531-7. doi: 
      10.3928/23258160-20150521-04.