PMID- 26058015
OWN - NLM
STAT- MEDLINE
DCOM- 20160303
LR  - 20181113
IS  - 1660-3397 (Electronic)
IS  - 1660-3397 (Linking)
VI  - 13
IP  - 6
DP  - 2015 Jun 5
TI  - Effect of Marine Collagen Peptides on Physiological and Neurobehavioral 
      Development of Male Rats with Perinatal Asphyxia.
PG  - 3653-71
LID - 10.3390/md13063653 [doi]
AB  - Asphyxia during delivery produces long-term deficits in brain development. We 
      investigated the neuroprotective effects of marine collagen peptides (MCPs), 
      isolated from Chum Salmon skin by enzymatic hydrolysis, on male rats with 
      perinatal asphyxia (PA). PA was performed by immersing rat fetuses with uterine 
      horns removed from ready-to-deliver rats into a water bath for 15 min. 
      Caesarean-delivered pups were used as controls. PA rats were intragastrically 
      administered with 0.33 g/kg, 1.0 g/kg and 3.0 g/kg body weight MCPs from 
      postnatal day 0 (PND 0) till the age of 90-days. Behavioral tests were carried 
      out at PND21, PND 28 and PND 90. The results indicated that MCPs facilitated 
      early body weight gain of the PA pups, however had little effects on early 
      physiological development. Behavioral tests revealed that MCPs facilitated 
      long-term learning and memory of the pups with PA through reducing oxidative 
      damage and acetylcholinesterase (AChE) activity in the brain, and increasing 
      hippocampus phosphorylated cAMP-response element binding protein (p-CREB) and 
      brain derived neurotrophic factor (BDNF) expression.
FAU - Xu, Linlin
AU  - Xu L
AD  - Department of Nutrition and Food Hygiene, School of Public Health, Peking 
      University, No. 38 Xue Yuan Road, Hai Dian District, Beijing 100191, China. 
      bmuliyong58@126.com.
FAU - Dong, Wenhong
AU  - Dong W
AD  - Department of Nutrition and Food Hygiene, School of Public Health, Peking 
      University, No. 38 Xue Yuan Road, Hai Dian District, Beijing 100191, China. 
      monydwh@163.com.
FAU - Zhao, Jie
AU  - Zhao J
AD  - Department of Nutrition and Food Hygiene, School of Public Health, Peking 
      University, No. 38 Xue Yuan Road, Hai Dian District, Beijing 100191, China. 
      zhaojie0410@sina.com.
FAU - Xu, Yajun
AU  - Xu Y
AD  - Department of Nutrition and Food Hygiene, School of Public Health, Peking 
      University, No. 38 Xue Yuan Road, Hai Dian District, Beijing 100191, China. 
      xuyajun@bjmu.edu.cn.
AD  - Beijing Key Laboratory of Toxicological Research and Risk Assessment for Food 
      Safety, Peking University, No. 38 Xue Yuan Road, Hai Dian District, Beijing 
      100191, China. xuyajun@bjmu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20150605
PL  - Switzerland
TA  - Mar Drugs
JT  - Marine drugs
JID - 101213729
RN  - 0 (Neuroprotective Agents)
RN  - 0 (Peptides)
RN  - 9007-34-5 (Collagen)
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Asphyxia Neonatorum/*drug therapy/physiopathology
MH  - Behavior, Animal/drug effects
MH  - Brain/drug effects/pathology
MH  - Collagen/isolation & purification/*pharmacology
MH  - Disease Models, Animal
MH  - Hippocampus/drug effects/pathology
MH  - Learning/drug effects
MH  - Male
MH  - Memory/drug effects
MH  - Neuroprotective Agents/isolation & purification/*pharmacology
MH  - Oncorhynchus keta/metabolism
MH  - Peptides/isolation & purification/*pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Skin/chemistry
MH  - Time Factors
PMC - PMC4483650
OTO - NOTNLM
OT  - marine collagen peptides
OT  - neurobehavioral development
OT  - perinatal asphyxia
EDAT- 2015/06/10 06:00
MHDA- 2016/03/05 06:00
PMCR- 2015/06/01
CRDT- 2015/06/10 06:00
PHST- 2015/02/28 00:00 [received]
PHST- 2015/05/21 00:00 [revised]
PHST- 2015/06/01 00:00 [accepted]
PHST- 2015/06/10 06:00 [entrez]
PHST- 2015/06/10 06:00 [pubmed]
PHST- 2016/03/05 06:00 [medline]
PHST- 2015/06/01 00:00 [pmc-release]
AID - md13063653 [pii]
AID - marinedrugs-13-03653 [pii]
AID - 10.3390/md13063653 [doi]
PST - epublish
SO  - Mar Drugs. 2015 Jun 5;13(6):3653-71. doi: 10.3390/md13063653.