PMID- 26058861
OWN - NLM
STAT- MEDLINE
DCOM- 20151022
LR  - 20181220
IS  - 1522-1555 (Electronic)
IS  - 0193-1849 (Print)
IS  - 0193-1849 (Linking)
VI  - 309
IP  - 3
DP  - 2015 Aug 1
TI  - Central effects of humanin on hepatic triglyceride secretion.
PG  - E283-92
LID - 10.1152/ajpendo.00043.2015 [doi]
AB  - Humanin (HN) is an endogenous mitochondria-associated peptide that has been shown 
      to protect against various Alzheimer's disease-associated insults, myocardial 
      ischemia-reperfusion injury, and reactive oxygen species-induced cell death. We 
      have shown previously that HN improves whole body glucose homeostasis by 
      improving insulin sensitivity and increasing glucose-stimulated insulin secretion 
      (GSIS) from the beta-cells. Here, we report that intraperitoneal treatment with one 
      of HN analogs, HNG, decreases body weight gain, visceral fat, and hepatic 
      triglyceride (TG) accumulation in high-fat diet-fed mice. The decrease in hepatic 
      TG accumulation is due to increased activity of hepatic microsomal triglyceride 
      transfer protein (MTTP) and increased hepatic TG secretion. Both intravenous (iv) 
      and intracerebroventricular (icv) infusion of HNG acutely increase TG secretion 
      from the liver. Vagotomy blocks the effect on both iv and icv HNG on TG 
      secretion, suggesting that the effects of HNG on hepatic TG flux are centrally 
      mediated. Our data suggest that HN is a new player in central regulation of 
      peripheral lipid metabolism.
CI  - Copyright (c) 2015 the American Physiological Society.
FAU - Gong, Zhenwei
AU  - Gong Z
AD  - Department of Pediatrics, Children's Hospital of Pittsburgh of the University of 
      Pittsburgh Medical Center, University of Pittsburgh School of Medicine, 
      Pittsburgh, Pennsylvania;
FAU - Su, Kai
AU  - Su K
AD  - Department of Pediatrics, Children's Hospital of Pittsburgh of the University of 
      Pittsburgh Medical Center, University of Pittsburgh School of Medicine, 
      Pittsburgh, Pennsylvania;
FAU - Cui, Lingguang
AU  - Cui L
AD  - Department of Pediatrics, Children's Hospital at Montefiore, Albert Einstein 
      College of Medicine, Bronx, New York; and.
FAU - Tas, Emir
AU  - Tas E
AD  - Department of Pediatrics, Children's Hospital of Pittsburgh of the University of 
      Pittsburgh Medical Center, University of Pittsburgh School of Medicine, 
      Pittsburgh, Pennsylvania;
FAU - Zhang, Ting
AU  - Zhang T
AD  - Department of Pediatrics, Children's Hospital of Pittsburgh of the University of 
      Pittsburgh Medical Center, University of Pittsburgh School of Medicine, 
      Pittsburgh, Pennsylvania;
FAU - Dong, H Henry
AU  - Dong HH
AD  - Department of Pediatrics, Children's Hospital of Pittsburgh of the University of 
      Pittsburgh Medical Center, University of Pittsburgh School of Medicine, 
      Pittsburgh, Pennsylvania;
FAU - Yakar, Shoshana
AU  - Yakar S
AD  - David B. Kriser Dental Center, Department of Basic Science and Craniofacial 
      Biology, New York University College of Dentistry, New York, New York.
FAU - Muzumdar, Radhika H
AU  - Muzumdar RH
AD  - Department of Pediatrics, Children's Hospital of Pittsburgh of the University of 
      Pittsburgh Medical Center, University of Pittsburgh School of Medicine, 
      Pittsburgh, Pennsylvania; radhika.muzumdar@chp.edu.
LA  - eng
GR  - R01 DK098437/DK/NIDDK NIH HHS/United States
GR  - K08-AG-027462/AG/NIA NIH HHS/United States
GR  - K08-AG-027462-03S1/AG/NIA NIH HHS/United States
GR  - R01-AG-035114/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20150609
PL  - United States
TA  - Am J Physiol Endocrinol Metab
JT  - American journal of physiology. Endocrinology and metabolism
JID - 100901226
RN  - 0 (Anti-Obesity Agents)
RN  - 0 (Carrier Proteins)
RN  - 0 (Central Nervous System Agents)
RN  - 0 (HNG peptide)
RN  - 0 (Intracellular Signaling Peptides and Proteins)
RN  - 0 (Peptides)
RN  - 0 (Triglycerides)
RN  - 0 (humanin)
RN  - 0 (microsomal triglyceride transfer protein)
SB  - IM
MH  - Adiposity/drug effects
MH  - Animals
MH  - Anti-Obesity Agents/administration & dosage/pharmacology/therapeutic use
MH  - Carrier Proteins/agonists/genetics/metabolism
MH  - Cells, Cultured
MH  - Central Nervous System Agents/administration & dosage/pharmacology/therapeutic 
      use
MH  - Diet, High-Fat/adverse effects
MH  - Hepatocytes/cytology/drug effects/metabolism
MH  - Infusions, Intravenous
MH  - Infusions, Intraventricular
MH  - Intra-Abdominal Fat/drug effects/pathology
MH  - Intracellular Signaling Peptides and Proteins/administration & 
      dosage/chemistry/*metabolism/pharmacology/therapeutic use
MH  - Liver/drug effects/*metabolism/pathology
MH  - Male
MH  - Mice, Inbred C57BL
MH  - *Models, Biological
MH  - Obesity/drug therapy/etiology/*metabolism/pathology
MH  - Peptides/administration & dosage/pharmacology/therapeutic use
MH  - Rats, Sprague-Dawley
MH  - Reproducibility of Results
MH  - Triglycerides/blood/*metabolism
MH  - Vagotomy, Truncal
PMC - PMC4525112
OTO - NOTNLM
OT  - hepatic microsomal triglyceride transfer protein
OT  - humanin
OT  - hypothalamus
OT  - triglyceride secretion
EDAT- 2015/06/11 06:00
MHDA- 2015/10/23 06:00
PMCR- 2016/08/01
CRDT- 2015/06/11 06:00
PHST- 2015/01/27 00:00 [received]
PHST- 2015/06/04 00:00 [accepted]
PHST- 2015/06/11 06:00 [entrez]
PHST- 2015/06/11 06:00 [pubmed]
PHST- 2015/10/23 06:00 [medline]
PHST- 2016/08/01 00:00 [pmc-release]
AID - ajpendo.00043.2015 [pii]
AID - E-00043-2015 [pii]
AID - 10.1152/ajpendo.00043.2015 [doi]
PST - ppublish
SO  - Am J Physiol Endocrinol Metab. 2015 Aug 1;309(3):E283-92. doi: 
      10.1152/ajpendo.00043.2015. Epub 2015 Jun 9.