PMID- 26059032
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150610
LR  - 20181113
IS  - 2051-817X (Print)
IS  - 2051-817X (Electronic)
IS  - 2051-817X (Linking)
VI  - 3
IP  - 6
DP  - 2015 Jun
TI  - Higher vascular endothelial growth factor-C concentration in plasma is associated 
      with increased forearm capillary filtration capacity in breast cancer-related 
      lymphedema.
LID - 10.14814/phy2.12403 [doi]
LID - e12403
AB  - Breast cancer-related lymphedema (BCRL) is a frequent, chronic and debilitating 
      swelling that mainly affects the ipsilateral arm and develops as a complication 
      to breast cancer treatment. The pathophysiology is elusive opposing development 
      of means for prediction and treatment. We have earlier shown that the forearm 
      capillary filtration coefficient (CFC) is increased bilaterally in BCRL. In this 
      study, we aimed to elucidate if increased CFC is associated with low-grade 
      inflammation and/or vascular endothelial growth factor-c (VEGF-C) signaling. 
      Fourteen patients with unilateral BCRL and nine matched breast cancer controls 
      without BCRL participated. Forearm CFC was measured by venous congestion strain 
      gauge plethysmography, and suction blisters were induced medially on the upper 
      arms. Concentrations of 17 selected cytokines, VEGF-C, and total protein were 
      measured in blister fluid and in plasma. Forearm CFC was higher bilaterally in 
      BCRL subjects (P </= 0.036). No differences between forearms were found in either 
      group. Plasma VEGF-C concentrations were significantly higher in the BCRL 
      subjects (P < 0.001). In BCRL subjects, monocyte chemotactic protein 1 (MCP-1) 
      (P = 0.009) and total protein (P = 0.035) concentrations were higher in blister 
      fluid from edematous arms compared with nonedematous arms. No differences were 
      found in interstitial cytokine or total protein concentrations between arms in 
      control subjects. Higher plasma concentration of VEGF-C is a possible cause of 
      bilaterally increased forearm CFC in BCRL subjects. Interstitially increased 
      MCP-1 levels may augment local microvascular protein permeability in BCRL.
CI  - (c) 2015 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on 
      behalf of the American Physiological Society and The Physiological Society.
FAU - Jensen, Mads Radmer
AU  - Jensen MR
AD  - Department of Clinical Physiology and Nuclear Medicine, Bispebjerg Hospital 
      University Hospital of Copenhagen, Copenhagen, Denmark Department of Dermatology, 
      Copenhagen Wound Healing Centre Copenhagen Lymphoedema Centre Bispebjerg Hospital 
      University Hospital of Copenhagen, Copenhagen, Denmark 
      mads.radmer.jensen@regionh.dk.
FAU - Simonsen, Lene
AU  - Simonsen L
AD  - Department of Clinical Physiology and Nuclear Medicine, Bispebjerg Hospital 
      University Hospital of Copenhagen, Copenhagen, Denmark.
FAU - Karlsmark, Tonny
AU  - Karlsmark T
AD  - Department of Dermatology, Copenhagen Wound Healing Centre Copenhagen Lymphoedema 
      Centre Bispebjerg Hospital University Hospital of Copenhagen, Copenhagen, 
      Denmark.
FAU - Lanng, Charlotte
AU  - Lanng C
AD  - Department of Breast Surgery, Herlev Hospital University Hospital of Copenhagen, 
      Copenhagen, Denmark.
FAU - Bulow, Jens
AU  - Bulow J
AD  - Department of Clinical Physiology and Nuclear Medicine, Bispebjerg Hospital 
      University Hospital of Copenhagen, Copenhagen, Denmark Department of Biomedical 
      Sciences, University of Copenhagen, Copenhagen, Denmark.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Physiol Rep
JT  - Physiological reports
JID - 101607800
PMC - PMC4510618
OTO - NOTNLM
OT  - Breast cancer
OT  - VEGF-C
OT  - capillary filtration coefficient
OT  - cytokine
OT  - inflammation
OT  - lymphedema
OT  - suction blister
OT  - venous occlusion plethysmography
EDAT- 2015/06/11 06:00
MHDA- 2015/06/11 06:01
PMCR- 2015/06/09
CRDT- 2015/06/11 06:00
PHST- 2015/06/11 06:00 [entrez]
PHST- 2015/06/11 06:00 [pubmed]
PHST- 2015/06/11 06:01 [medline]
PHST- 2015/06/09 00:00 [pmc-release]
AID - 3/6/e12403 [pii]
AID - 10.14814/phy2.12403 [doi]
PST - ppublish
SO  - Physiol Rep. 2015 Jun;3(6):e12403. doi: 10.14814/phy2.12403.