PMID- 26061230
OWN - NLM
STAT- MEDLINE
DCOM- 20160203
LR  - 20220110
IS  - 1361-6560 (Electronic)
IS  - 0031-9155 (Linking)
VI  - 60
IP  - 13
DP  - 2015 Jul 7
TI  - GGEMS-Brachy: GPU GEant4-based Monte Carlo simulation for brachytherapy 
      applications.
PG  - 4987-5006
LID - 10.1088/0031-9155/60/13/4987 [doi]
AB  - In brachytherapy, plans are routinely calculated using the AAPM TG43 formalism 
      which considers the patient as a simple water object. An accurate modeling of the 
      physical processes considering patient heterogeneity using Monte Carlo simulation 
      (MCS) methods is currently too time-consuming and computationally demanding to be 
      routinely used. In this work we implemented and evaluated an accurate and fast 
      MCS on Graphics Processing Units (GPU) for brachytherapy low dose rate (LDR) 
      applications. A previously proposed Geant4 based MCS framework implemented on GPU 
      (GGEMS) was extended to include a hybrid GPU navigator, allowing navigation 
      within voxelized patient specific images and analytically modeled (125)I seeds 
      used in LDR brachytherapy. In addition, dose scoring based on track length 
      estimator including uncertainty calculations was incorporated. The implemented 
      GGEMS-brachy platform was validated using a comparison with Geant4 simulations 
      and reference datasets. Finally, a comparative dosimetry study based on the 
      current clinical standard (TG43) and the proposed platform was performed on 
      twelve prostate cancer patients undergoing LDR brachytherapy. Considering patient 
      3D CT volumes of 400  x 250  x 65 voxels and an average of 58 implanted seeds, 
      the mean patient dosimetry study run time for a 2% dose uncertainty was 9.35 s 
      ( approximately 500 ms 10(-6) simulated particles) and 2.5 s when using one and four GPUs, 
      respectively. The performance of the proposed GGEMS-brachy platform allows 
      envisaging the use of Monte Carlo simulation based dosimetry studies in 
      brachytherapy compatible with clinical practice. Although the proposed platform 
      was evaluated for prostate cancer, it is equally applicable to other LDR 
      brachytherapy clinical applications. Future extensions will allow its application 
      in high dose rate brachytherapy applications.
FAU - Lemarechal, Yannick
AU  - Lemarechal Y
AD  - LaTIM, UMR1101, INSERM, CHRU Brest, France.
FAU - Bert, Julien
AU  - Bert J
AD  - LaTIM, UMR1101, INSERM, CHRU Brest, France.
FAU - Falconnet, Claire
AU  - Falconnet C
AD  - Service de radiotherapie, CHRU Brest, France.
FAU - Despres, Philippe
AU  - Despres P
AD  - Departement de radio-oncologie and Centre de recherche du CHU de Quebec, Quebec 
      QC, Canada.
AD  - Department de physique, de genie physique et d'optique and Centre de recherche 
      sur le cancer, Universite Laval, Quebec QC, Canada.
FAU - Valeri, Antoine
AU  - Valeri A
AD  - Department de physique, de genie physique et d'optique and Centre de recherche 
      sur le cancer, Universite Laval, Quebec QC, Canada.
AD  - Service d'urologie, CHRU Brest, France.
FAU - Schick, Ulrike
AU  - Schick U
AD  - LaTIM, UMR1101, INSERM, CHRU Brest, France.
AD  - Service de radiotherapie, CHRU Brest, France.
FAU - Pradier, Olivier
AU  - Pradier O
AD  - LaTIM, UMR1101, INSERM, CHRU Brest, France.
AD  - Service de radiotherapie, CHRU Brest, France.
FAU - Garcia, Marie-Paule
AU  - Garcia MP
AD  - LaTIM, UMR1101, INSERM, CHRU Brest, France.
FAU - Boussion, Nicolas
AU  - Boussion N
AD  - LaTIM, UMR1101, INSERM, CHRU Brest, France.
AD  - Service de radiotherapie, CHRU Brest, France.
FAU - Visvikis, Dimitris
AU  - Visvikis D
AD  - LaTIM, UMR1101, INSERM, CHRU Brest, France.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150610
PL  - England
TA  - Phys Med Biol
JT  - Physics in medicine and biology
JID - 0401220
SB  - IM
MH  - *Algorithms
MH  - Brachytherapy/*methods
MH  - Humans
MH  - Male
MH  - Monte Carlo Method
MH  - Prostatic Neoplasms/*radiotherapy
MH  - *Radiation Dosage
MH  - Radiotherapy Dosage
MH  - Radiotherapy Planning, Computer-Assisted/*methods
EDAT- 2015/06/11 06:00
MHDA- 2016/02/04 06:00
CRDT- 2015/06/11 06:00
PHST- 2015/06/11 06:00 [entrez]
PHST- 2015/06/11 06:00 [pubmed]
PHST- 2016/02/04 06:00 [medline]
AID - 10.1088/0031-9155/60/13/4987 [doi]
PST - ppublish
SO  - Phys Med Biol. 2015 Jul 7;60(13):4987-5006. doi: 10.1088/0031-9155/60/13/4987. 
      Epub 2015 Jun 10.