PMID- 26061354
OWN - NLM
STAT- MEDLINE
DCOM- 20160822
LR  - 20151104
IS  - 1473-5849 (Electronic)
IS  - 0955-8810 (Linking)
VI  - 26
IP  - 8 Spec No
DP  - 2015 Dec
TI  - Effects of psychostimulants on social interaction in adult male rats.
PG  - 776-85
LID - 10.1097/FBP.0000000000000148 [doi]
AB  - Psychostimulants are known to have a huge impact on different forms of social 
      behaviour. The aim of the present study was to compare the effects of three 
      different psychostimulants [amphetamine, cocaine and 3,4 
      methylenedimethoxyamphetamine (MDMA)] on social interaction (SI) in adult male 
      rats. The SI test was performed in a familiar arena and under low-stress 
      environmental conditions. Experimental animals received amphetamine (0.5, 1.0, 
      1.5 mg/kg), cocaine (0.5, 1.0, 1.5, 2.5, 5.0, 10.0 mg/kg) or MDMA (2.5, 5.0, 10 
      mg/kg) and control animals received saline (1 ml/kg) 45 min before the SI test. 
      Time spent in SI (individual patterns of social behaviour) and nonsocial 
      activities (locomotion and rearing) were video recorded and then analysed 
      offline, with the following results: (a) all doses of amphetamine decreased SI. 
      Specifically, all doses of amphetamine decreased mutual sniffing, and the higher 
      doses also decreased allo-grooming and following behaviours. (b) The higher doses 
      of cocaine decreased SI, especially mutual sniffing, allo-grooming and climbing 
      over. Cocaine at the dose of 5.0 mg/kg increased genital investigation compared 
      with lower doses. (c) All doses of MDMA decreased mutual sniffing and climbing 
      over; the two higher doses decreased allo-grooming behaviour, and only the 
      highest dose decreased following. The two higher doses of amphetamine and all the 
      doses of MDMA increased locomotion and rearing; cocaine did not affect 
      locomotion, but increased rearing at higher doses. In conclusion, the results 
      confirm the well-known finding that psychostimulants suppress SI, but also show 
      novel differences in the effects of psychostimulants on specific patterns of SI.
FAU - Slamberova, Romana
AU  - Slamberova R
AD  - aDepartment of Normal, Pathological and Clinical Physiology, Third Faculty of 
      Medicine, Charles University in Prague bDepartment of Developmental Epileptology, 
      Academy of Sciences of the Czech Republic, Institute of Physiology, Prague, Czech 
      Republic.
FAU - Mikulecka, Anna
AU  - Mikulecka A
FAU - Macuchova, Eva
AU  - Macuchova E
FAU - Hrebickova, Ivana
AU  - Hrebickova I
FAU - Sevcikova, Maria
AU  - Sevcikova M
FAU - Nohejlova, Kateryna
AU  - Nohejlova K
FAU - Pometlova, Marie
AU  - Pometlova M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Behav Pharmacol
JT  - Behavioural pharmacology
JID - 9013016
RN  - 0 (Central Nervous System Stimulants)
RN  - CK833KGX7E (Amphetamine)
RN  - I5Y540LHVR (Cocaine)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Amphetamine/pharmacology
MH  - Animals
MH  - Behavior, Animal/*drug effects
MH  - Central Nervous System Stimulants/*pharmacology
MH  - Cocaine/pharmacology
MH  - Dose-Response Relationship, Drug
MH  - *Interpersonal Relations
MH  - Locomotion/drug effects
MH  - Male
MH  - Motor Activity/drug effects
MH  - N-Methyl-3,4-methylenedioxyamphetamine/pharmacology
MH  - Rats
MH  - Rats, Wistar
EDAT- 2015/06/11 06:00
MHDA- 2016/08/23 06:00
CRDT- 2015/06/11 06:00
PHST- 2015/06/11 06:00 [entrez]
PHST- 2015/06/11 06:00 [pubmed]
PHST- 2016/08/23 06:00 [medline]
AID - 10.1097/FBP.0000000000000148 [doi]
PST - ppublish
SO  - Behav Pharmacol. 2015 Dec;26(8 Spec No):776-85. doi: 
      10.1097/FBP.0000000000000148.